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What causes Multiple Sclerosis? MS Answers

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  • Billsfan
    Dr. Murray Professor Emeritus of Medicine (Neurology) View BIO ExpertBio.aspx?L=2&EID=32 Q : I have heard that a prion may be involved in causing MS. Could you
    Message 1 of 1 , Sep 1 7:08 AM
      Dr. Murray


      Professor Emeritus of Medicine (Neurology)


      View BIO

      ExpertBio.aspx?L=2&EID=32
      Q :

      I have heard that a prion may be involved in causing MS. Could you tell
      me what a prion is, and how it might be connected to MS?

      A :

      Infection has been postulated as a cause of MS without finding a
      definite answer since the search began over 125 years ago. At the
      present time the prevailing view is that MS has a genetic
      predisposition, but that some triggering agent or factor is involved in
      determining whether the predisposed person develops the disease. One of
      the leading theories is that an infectious agent is the triggering agent.

      In the search for which infectious agent might be involved many bacteria
      and viruses have been suspected, with only faint evidence for each.
      Perhaps any infectious agent that disrupts the blood brain barrier and
      allows an immunological process to be initiated might be involved.

      In the 1960's a new kind of infection, the slow virus, was discovered
      and MS was suspected of being a slow virus disease like Creutzfelt
      -Jacob Disease, but all attempts to transmit the disease in the way slow
      viruses are transmitted failed and that theory waned. When Stanley
      Pruziner and others recently postulated the concept of prion disease,
      due to infective particles that are unlike viruses in that they contain
      no nucleic acids, many wondered if MS could be a prion disease.

      At this point the idea is only a theory, and there has been no solid
      evidence that it is true and Stanley Pruziner himself does not have MS
      on his list of diseases he suspects may be prion diseases.

      So, at this point it is a theory in the search for the cause of MS, but
      one that is not widely held. It is possible that prions are responsible
      for many other neurological diseases but until we have more evidence,
      our minds are open to many possibilities for the cause of MS.


      9/1/2008 8:20:46 AM


      More answers from Dr. Jock Murray
      http://www.msanswers.ca/QuestionListByExpert.aspx?EID=32&L=2


      More answers in the category: Diagnosis and Types of MS
      http://www.msanswers.ca/QuestionList.aspx?CID=3&L=2



      DISCLAIMER: Please be aware that this information does not necessarily
      represent the opinion of the MS Society of Canada, and is not intended
      as medical advice. For specific advice and opinion, always consult a
      physician.

      © 2008 Multiple Sclerosis Society of Canada | www.mssociety.ca
      http://www.mssociety.ca

      http://www.msanswers.ca/QuestionView.aspx?L=2&QID=953


      ------------------------------------------------------------------------



      Enrollment Complete In 15-Year Long-Term Follow-Up Study Evaluating
      Impact Of AVONEX(R) In Patients With Relapsing Multiple Sclerosis
      Biogen Idec announced that enrollment is complete in the ASSURANCE
      trial, a long-term follow-up study which will assess up to 15 years of
      AVONEX® (interferon beta-1a) treatment in an effort to provide detailed
      data on the long term efficacy of the drug.
      http://www.medicalnewstoday.com/articles/119708.php




      FDA Wants Biogen, Elan Drug Warning Revised
      From Reuters Health - Aug 25, 2008
      WASHINGTON (Reuters) - Prescribing instructions for Biogen Idec and Elan
      Corp's drug Tysabri should be revised to note cases of a serious brain
      disorder in patients who were using it as their sole treatment for
      multiple sclerosis, U.S. health regulators said on Monday.
      Read Full Article Article Summary
      http://emailactivity.ecn5.com/engines/linkfrom.aspx?b=128531&e=27513351&l=http://www.therapeuticsdaily.com/news/article.cfm?contentvalue=1828705&contenttype=sentryarticle&channelID=30
      http://emailactivity.ecn5.com/engines/linkfrom.aspx?b=128531&e=27513351&l=http://www.therapeuticsdaily.com/news/article.cfm?contentvalue=1828705&contenttype=sentryarticle&channelID=30


      Treadmill Exercise Retrains Brain And Body Of Stroke Victims
      People who walk on a treadmill even years after stroke damage can
      significantly improve their
      health and mobility, changes that reflect actual "rewiring" of their
      brains, according to research spearheaded at Johns Hopkins.
      http://www.medicalnewstoday.com/articles/119732.php


      Memory Trick Shows Brain Organization
      A simple memory trick has helped show UC Davis researchers how an area
      of the brain called
      the perirhinal cortex can contribute to forming memories. The finding
      expands our understanding
      of how those brain areas that form memories are organized.
      http://www.medicalnewstoday.com/articles/119705.php


      Marine's mechanical skills led to a career
      Greeley Tribune - Greeley,Colorado,USA
      "I had three sisters, and when our father came down with multiple
      sclerosis,
      I had to leave school at 12 years old and go to work. ...

      http://www.greeleytribune.com/article/20080831/VETS/108319977/1033&parentprofile=-1

      Makers of MS Drug Confirm Two Cases of Life-Threatening Brain ...
      MedPage Today - Little Falls,NJ,USA
      1 -- Two multiple sclerosis patients -- both in Europe -- have developed
      progressive multifocal leukoencephalopathy (PML) as a result of
      treatment with ...
      http://www.medpagetoday.com/Neurology/MultipleSclerosis/tb/10385


      Health News from Medical News Today (60 ?????????)
      By sara(sara)

      Enrollment Complete In 15-Year Long-Term Follow-Up Study Evaluating
      Impact Of AVONEX(R) In Patients With Relapsing Multiple Sclerosis Biogen
      Idec announced that enrollment is complete in the ASSURANCE trial, a
      long-term follow-up study ...
      Medici - http://medic-art.blogspot.com/

      http://medic-art.blogspot.com/2008/08/health-news-from-medical-news-today-60_31.html


      Seattle Discriminates Against People Without People
      By Diane J Standiford(Diane J Standiford)
      I have multiple sclerosis, diagnosed in 1990, and for the past 11 years
      my left fingers have been heading toward contractures. It started with
      my pinkie in 1997, making typing on my keyboard at work very difficult. ...
      - http://disabledinseattle.blogspot.com/

      http://disabledinseattle.blogspot.com/2008/09/seattle-discriminates-against-people.html


      ------------------------------------------------------------------------


      Diagnosis and Types of MS



      Dr. Girard

      Neurologist, Hôtel-Dieu Hospital (CHUM)in Montreal, QC


      <http://www.msanswers.ca/ExpertBio.aspx?L=2&EID=26>View BIO
      http://www.msanswers.ca/ExpertBio.aspx?L=2&EID=26

      Q :

      Does a lumbar puncture provide 100% proof that someone has MS?
      A :

      The lumbar puncture is a useful test for diagnosing multiple sclerosis,
      but it is not sufficient by itself to make a diagnosis. The diagnosis of
      the disease mainly depends on clinical aspects, that is, the history
      that you give the neurologist about various symptoms that you have
      experienced, which may relate to this disease and by a neurological
      examination by your physician, which indicates anomalies confirming
      symptoms that you have noted.

      If the clinical examination is highly suggestive of MS, magnetic
      resonance image (MRI) will allow us to confirm the physician's clinical
      impressions. The reverse is also true, that is, a normal MRI would
      eliminate the diagnosis of multiple sclerosis if the neurologist's
      clinical impression is that the patient does not have multiple sclerosis.

      Lumbar puncture is mainly used in disputed cases. If the clinical
      history is convincing for a diagnosis of multiple sclerosis, but the MRI
      is unclear, the presence of anomalies in the analysis of cerebrospinal
      fluid (CSF) obtained by a lumbar puncture would allow the neurologist to
      confirm the diagnosis. The analysis of CSF is also useful if the
      clinical history is not convincing but magnetic resonance strongly
      suggests the disease. Lumbar puncture is also frequently used for the
      diagnosis of patients with the primary progressive type of multiple
      sclerosis.

      Despite significant advances made in recent decades in diagnosing the
      disease, mainly by using MRI, lumbar puncture remains important by
      adding information that it alone can provide.

      9/1/2008 8:57:36 AM

      More answers from Dr. Marc Girard
      http://www.msanswers.ca/QuestionListByExpert.aspx?EID=32&L=2


      More answers in the category: Diagnosis and Types of MS
      http://www.msanswers.ca/QuestionList.aspx?CID=3&L=2

      DISCLAIMER: Please be aware that this information does not necessarily
      represent the opinion of the MS Society of Canada, and is not intended
      as medical advice. For specific advice and opinion, always consult a
      physician.

      © 2008 Multiple Sclerosis Society of Canada | www.mssociety.ca
      http://www.mssociety.ca


      http://www.msanswers.ca/QuestionView.aspx?L=2&QID=2165




      ------------------------------------------------------------------------


      Fish oil capsules cut death rate in heart failure
      Reuters - USA
      Pronova is a world leader in producing pharmaceuticals from fish oil, a
      rich source of omega-3 fatty acids. The news also vindicates
      GlaxoSmithKline's (GSK. ...
      http://www.reuters.com/article/rbssHealthcareNews/idUSLV496420080831
      <http://news.google.com/news?hl=en&ncl=http://www.reuters.com/article/rbssHealthcareNews/idUSLV496420080831>



      Fish oil appears to help against heart failure
      The Associated Press -
      Omega-3 fatty acids from fish such as salmon and tuna have long been
      proven to offer health benefits like protecting the heart and brain,
      though scientists ...

      http://ap.google.com/article/ALeqM5jx8CJnyF1lxUTW3up_vbLUM1_ajwD92TBS1G0

      <http://news.google.com/news?hl=en&ncl=http://ap.google.com/article/ALeqM5jx8CJnyF1lxUTW3up_vbLUM1_ajwD92TBS1G0>


      Rapid Changes In Key Alzheimer's Protein Described In Humans
      For the first time, researchers have described hour-by-hour changes in
      the amount of amyloid beta, a protein that is believed to play a key
      role in Alzheimer's disease, in the human brain. A collaborative team of
      scientists at Washington University School of Medicine in St.
      http://www.medicalnewstoday.com/articles/119731.php




      Study Helps Strengthen Darwin's Natural Selection Theory
      Shedding some genetically induced excess baggage may have helped a tiny
      fish thrive in freshwater and outsize its marine ancestors, according to
      a UBC study published in Science Express.Measuring three to 10
      centimetres long, stickleback fish originated in the ocean but began
      populating freshwater lakes and streams following the last ice age.
      http://www.medicalnewstoday.com/articles/119709.php



      More Than 500,000 Have Cancer In The U.S. But 98% Don't Take Part In Trials
      Americans are some of the most generous people in the world, whether
      it's donating time or money, each year more than 60 million of us
      volunteer* to help others. But that's not always the case when it comes
      to cancer research.
      http://www.medicalnewstoday.com/articles/119695.php




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