A New Line Of Communication Between Nervous System Cells Discovered By Weizmann Scientists
- A New Line Of Communication Between Nervous System Cells
Discovered By Weizmann Scientists
Main Category: Neurology / Neuroscience News
Article Date: 30 Jun 2007 - 13:00 PDT
In a host of neurological diseases, including multiple sclerosis (MS)
and several neuropathies, the protective covering surrounding the nerves
- an insulating material called myelin - is damaged. Scientists at the
Weizmann Institute of Science have now discovered an important new line
of communication between nervous system cells that is crucial to the
development of myelinated nerves - a discovery that may aid in restoring
the normal function of the affected nerve fibers.
Nerve cells (neurons) have long, thin extensions called axons that can
reach up to a meter and or more in length. Often, these extensions are
covered by myelin, which is formed by a group of specialized cells
called glia. Glial cells revolve around the axon, laying down the myelin
sheath in segments, leaving small nodes of exposed nerve in between.
More than just protection for the delicate axons, the myelin covering
allows nerve signals to jump instantaneously between nodes, making the
transfer of these signals quick and efficient. When myelin is missing or
damaged, the nerve signals can't skip properly down the axons, leading
to abnormal function of the affected nerve and often to its degeneration.
In research published recently in Nature Neuroscience, Weizmann
Institute scientists Prof. Elior Peles, graduate student Ivo Spiegel,
and their colleagues in the Molecular Cell Biology Department and in the
United States, have now provided a vital insight into the mechanism by
which glial cells recognize and myelinate axons.
How do the glial cells and the axon coordinate this process" The
Weizmann Institute team found a pair of proteins that pass messages from
axons to glial cells. These proteins, called Necl1 and Necl4, belong to
a larger family of cell adhesion molecules, so called because they sit
on the outer membranes of cells and help them to stick together. Peles
and his team discovered that even when removed from their cells, Necl1,
normally found on the axon surface, and Necl4, which is found on the
glial cell membrane, adhere tightly together. When these molecules are
in their natural places, they not only create physical contact between
axon and glial cell, but also serve to transfer signals to the cell
interior, initiating changes needed to undertake myelination.
The scientists found that production of Necl4 in the glial cells rises
when they come into close contact with an unmyelinated axon, and as the
process of myelination begins. They observed that if Necl4 is absent in
the glial cells, or if they blocked the attachment of Necl4 to Necl1,
the axons that were contacted by glial cells did not myelinate. In the
same time period, myelin wrapping was already well underway around most
of the axons in the control group.
"What we've discovered is a completely new means of communication
between these nervous system cells," says Peles. "The drugs now used to
treat MS and other degenerative diseases in which myelin is affected can
only slow the disease, but not stop or cure it. Today, we can't reverse
the nerve damage caused by these disorders. But if we can understand the
mechanisms that control the process of wrapping the axons by their
protective sheath, we might be able to recreate that process in patients."
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