- I found this article on MEDLINE thought some would find it interesting.
A severe adverse reaction to mefloquine and chloroquine prophylaxis.
Lysack JT, Lysack CL, Kvern BL
School of Medicine, Faculty of Health Sciences, Queen's University,
Kingston, Ontario, Canada.
[Medline record in process]
A 23 year old man with no history of neurological or psychiatric illness
ingested three weekly 228 mg doses of mefloquine base (250 mg salt) as
malaria prophylaxis while in
India. He experienced an increasingly severe adverse reaction after each
dose, including symptoms of paranoia, hallucinations, and suicidal
ideation. The man discontinued
mefloquine and continued malaria prophylaxis with chloroquine. Shortly
after the first 300 mg dose of chloroquine base (500 mg chloroquine
phosphate salt), symptoms acutely
intensified and became debilitating. Severe symptoms persisted for 12
months following the discontinuation of both antimalarial drugs.
PMID: 9919736, UI: 99118389