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Key Links Between Mechanisms of Aging and Metabolic Disorders

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  • Michael Korns
    Nature Publication Reports Key Links Between Mechanisms of Aging and Metabolic Disorders CAMBRIDGE, Mass., July 5 /PRNewswire/ -- During the last decade
    Message 1 of 1 , Jul 5, 2005
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      Nature Publication Reports

      Key Links Between Mechanisms of Aging and Metabolic Disorders

      CAMBRIDGE, Mass., July 5 /PRNewswire/ -- During the last decade
      researchers have made a number of important discoveries about the
      molecular mechanisms regulating aging. This research has suggested
      the exciting prospect that the rate of aging can be manipulated and
      slowed, leading to longer human lifespan. A major peer-reviewed
      article in the current issue of Nature Reviews Drug Discovery
      describes the intimate links between these pathways of aging and
      those of metabolic disease, such as type 2 diabetes and obesity. The
      authors describe how these insights open the door to novel classes of
      drugs, which can be developed to not only treat diabetes and obesity,
      but also effectively slow the aging process and extend lifespan.
      These and other findings are reviewed in the article, "Aging and
      Metabolism: Drug Discovery Opportunities," authored by Elixir
      Pharmaceuticals' researchers Drs. Rory Curtis, Bard J. Geesaman and
      Peter S. DiStefano and appearing in Nature Reviews Drug Discovery
      (July 2005, Vol. 4, No. 7).

      John Kopchick, Ph.D., Goll-Ohio Eminent Scholar and Professor of
      Molecular Biology, Department of Biomedical Sciences, Konneker
      Research Center, Ohio University, commented, "This article provides
      an elegant and comprehensive survey of the essential connections
      between metabolic disease pathways and aging. The potential of this
      research is profound: Modulating these pathways may not only uncover
      yet unknown therapeutic targets and/or drugs to treat metabolic
      disease, but also has the potential to impact the progression of
      aging itself."...
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