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Study shows skin-surface biopsy reveals high density demodex mite count

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  • bradybarrows
    A standardized skin-surface biopsy (1 cm2) of the cheek was performed in 49 patients with rosacea [13 with erythematotelangiectatic rosacea (ETR). three with
    Message 1 of 1 , Feb 1, 2010
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      A standardized skin-surface biopsy (1 cm2) of the cheek was performed in 49 patients with rosacea [13 with erythematotelangiectatic rosacea (ETR). three with squamous rosacea (SR), 33 with papulopustular rosacea (PPR)], and 45 controls.

      A mean density of 0.7 Demodex folliculorum/cm2 was found in controls, 98% of whom had less than five Demodex/cm2. When all clinical types of rosacea were considered collectively, the density of Demodex was significantly higher in patients with rosacea than in controls (mean=10.8/cm2: P<0.001). When the various clinical types of rosacea were considered separately. Demodex density was statistically significantly higher than in controls only in the PPR patients (mean=12.8/cm2; P<0.001).

      The same type of comparison was also made for three other groups of subjects—patients with isolated inflammatory papules (n=4). rhinophyma (n=3), and HIV infection (n=21), respectively: in these groups, the Demodex density did not differ significantly from controls.

      The present study demonstrates a high density of D. folliculorum in PPR, and supports its pathogenic role in the papulopustular phase of rosacea. The study suggests that standardized surface biopsy could be a useful diagnostic tool for PPR, with a 98% specificity when Demodex density is higher than 5/cm2.

      http://www3.interscience.wiley.com/journal/119290363/abstract?CRETRY=1&SRETRY=0

      Brady
      group owner
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