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[psychiatry-research] Meta-Analysis of Regional Brain Volumes in Schizophrenia

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  • Ian Pitchford
    http://ajp.psychiatryonline.org/cgi/content/abstract/157/1/16 Am J Psychiatry 157:16-25, January 2000 Special Article Meta-Analysis of Regional Brain Volumes
    Message 1 of 1 , Jan 4, 2000
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      http://ajp.psychiatryonline.org/cgi/content/abstract/157/1/16
      Am J Psychiatry 157:16-25, January 2000
      Special Article

      Meta-Analysis of Regional Brain Volumes in Schizophrenia
      Ian C. Wright, M.R.C.P., M.R.C.Psych., Sophia Rabe-Hesketh, B.Sc., Ph.D.,
      Peter W.R. Woodruff, Ph.D., M.R.C.Psych., Anthony S. David, M.D.,
      F.R.C.Psych., Robin M. Murray, D.Sc., F.R.C.Psych. and Edward T. Bullmore,
      Ph.D., M.R.C.Psych.

      OBJECTIVE: The authors' goal was to determine whether patients with
      schizophrenia differ from comparison subjects in regional brain volumes and
      whether these differences are similar in male and female subjects. METHOD:
      They conducted a systematic search for structural magnetic resonance
      imaging (MRI) studies of patients with schizophrenia that reported volume
      measurements of selected cortical, subcortical, and ventricular regions in
      relation to comparison groups. They carried out a meta-analysis of the
      volumes of these regions in the patients with schizophrenia and the
      comparison subjects using a random effects model; they also used random
      effects regression analysis to examine the influence of gender on effect
      sizes. RESULTS: Fifty-eight studies were identified as suitable for
      analysis; these studies included 1,588 independent patients with
      schizophrenia. Assuming a volume of 100% in the comparison group, they
      found that the mean cerebral volume of the subjects with schizophrenia was
      smaller (98%), but the mean total ventricular volume of the subjects with
      schizophrenia was greater (126%). Relative to the cerebral volume
      differences, the regional volumes of the subjects with schizophrenia were
      94% in the left and right amygdala, 94% in the left and 95% in the right
      hippocampus/amygdala, and 93% in the left and 95% in the right
      parahippocampus. Relative to the global ventricular system differences, the
      largest differences in ventricular subdivisions were in the right and left
      body of the lateral ventricle, where the volumes of schizophrenic subjects
      were 116% and 116%, respectively. For most regions, effect size was not
      significantly related to gender. CONCLUSIONS: Regional structural
      differences in patients with schizophrenia include bilaterally reduced
      volume of medial temporal lobe structures. There is a need for greater
      integration of results from structural MRI studies to avoid redundant
      research activity.

      Full text, subscribers only:
      http://ajp.psychiatryonline.org/cgi/content/full/157/1/16
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