In Our Hearts (and Brains) We Knew This to be True
- In Our Hearts (and Brains) We Knew This to be True
JOURNAL: Nature Medicine, August 5, 2012
Treatment-induced damage to the tumor microenvironment
promotes prostate cancer therapy resistance through WNT16B
LEAD AUTHOR: Yu Sun, et. al.
"Acquired resistance to anticancer treatments is a
substantial barrier to reducing the morbidity and
mortality that is attributable to malignant tumors.
"Components of tissue microenvironments are recognized
to profoundly influence cellular phenotypes, including
susceptibilities to toxic insults.
"Using a genome-wide analysis of transcriptional responses
to genotoxic stress induced by cancer therapeutics, we
identified a spectrum of secreted proteins derived from
the tumor microenvironment that includes the Wnt family
member wingless-type MMTV integration site family member
"The expression of WNT16B in the prostate tumor microenvironment
attenuated the effects of cytotoxic chemotherapy in vivo,
promoting tumor cell survival and disease progression.
"These results delineate a mechanism by which genotoxic
therapies given in a cyclical manner can enhance subsequent
treatment resistance through cell nonautonomous effects that
are contributed by the tumor microenvironment."
* * * * *
In other words:
Just Say NO to Cancer treatments which include chemotherapy.
Rather than cure, they often accelerate the growth and
proliferation of existing cancers.