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Sweeter than Sweet; Saltier than Salt; More Sour than an Aborted Fetus

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  • cohensmilk1
    Sweeter than Sweet; Saltier than Salt; More Sour than an Aborted Fetus Sugar, ahhh - - honey honey you are my candy girl and you got me wanting you I just
    Message 1 of 1 , May 1, 2008
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      Sweeter than Sweet; Saltier than Salt;
      More Sour than an Aborted Fetus

      Sugar, ahhh - - honey honey
      you are my candy girl
      and you got me wanting you
      I just can't believe the loveliness of loving you
      (I just can't believe its true)
      I just can believe the wonder of this feeling too
      (I just can't believe its true)
      --Wilson Pickett, 1970 (Written by Barry and Andy Kim)

      We are witnessing the dawning of a sci-fi food revolution.
      A new technology. A new food group. Amazingly, my research
      uncovered something nobody has ever revealed before in a column,
      newspaper article, or magazine expose. The next time you read
      "artificial flavor" on a food label, you should be aware that
      a component of that new genetically engineered food additive
      may be embryonic kidney cells from aborted human fetuses.

      The new high-tech artificial flavors are not flavors at all.
      Instead, they contain chemicals which have been engineered
      to fool human taste buds. Future foods will need no salt, sugar,
      MSG, or artificial sweeteners. Instead, sensory perceptions will
      become warped by modern science. Brains will taste things that
      are not really there. Illusions. Deceptions. Memories of taste
      which are now artificially induced.

      You may not understand the abstract of the most recent publication
      from this new food science, as published in the May 2, 2008 issue
      of the Journal of Biochemistry. I will translate.

      The Abstract:


      J Biol Chem. 2008 May 2;283(18):11981-94.
      Small molecule activator of the human epithelial sodium
      channel.Lu M, Echeverri F, Kalabat D, Laita B, Dahan DS,
      Smith RD, Xu H, Staszewski L, Yamamoto J, Ling J, Hwang N,
      Kimmich R, Li P, Patron E, Keung W, Patron A, Moyer BD.
      Senomyx, Inc., San Diego, California 92121.

      The epithelial sodium channel (ENaC), a heterotrimeric complex
      composed of alpha, beta, and gamma subunits, belongs to the
      ENaC/degenerin family of ion channels and forms the principal
      route for apical Na(+) entry in many reabsorbing epithelia.

      Although high affinity ENaC blockers, including amiloride and
      derivatives, have been described, potent and specific small
      molecule ENaC activators have not been reported. Here we
      describe compound S3969 that fully and reversibly activates
      human ENaC (hENaC) in an amiloride-sensitive and dose-dependent
      manner in heterologous cells. Mechanistically, S3969 increases
      hENaC open probability through interactions requiring the
      extracellular domain of the beta subunit. hENaC activation by
      S3969 did not require cleavage by the furin protease, indicating
      that nonproteolyzed channels can be opened. Function of
      alphabetaG37Sgamma hENaC, a channel defective in gating that
      leads to the salt-wasting disease pseudohypoaldosteronism type I,
      was rescued by S3969. Small molecule activation of hENaC may find
      application in alleviating human disease, including
      pseudohypoaldosteronism type I, hypotension, and neonatal
      respiratory distress syndrome, when improved Na(+) flux across
      epithelial membranes is clinically desirable.


      OK, so what does it all mean? Another question:

      What's $6 today and $100 in the Near Future?

      One share of stock from a company called Senomyx.
      SNMX trades on NASDAQ


      From the Senomyx website:

      "Flavors are substances that impart tastes or aromas in
      foods and beverages. Individuals experience the sensation
      of taste when flavors in food and beverage products interact
      with taste receptors in the mouth...signals are sent to the
      brain where a specific taste sensation is registered.

      We have discovered or in-licensed many of the key receptors
      that mediate taste in humans. Having isolated human taste
      receptors, we have created proprietary taste receptor-based
      assay systems...has enabled us to improve our ability to
      find novel flavor enhancers...As a result, we have synthesized
      and discovered hundreds of unique potential flavor enhancers and
      taste modulators."

      Translation: Senomyx is re-inventing food and flavor by genetically
      engineering taste bud receptor cell triggers. Foods of the future
      will contain "flavor enhancers" which fool human taste buds into
      perceiving the sensations of sweetness, sourness, saltiness, and

      Remember the artificial sweetener controversies? Chemical
      sugar-replicating compounds are listed on food labels. The
      new chemicals made by biotech companies will require no
      such labels. Although they are not actual flavors, they will
      be called "artificial flavors."

      How did Senomyx accomplish the task? A (multi-hour) review of
      their patents reveals that it all began with the cloning of
      human embryonic kidney cells. Step two was a recombinant
      process involving the combination of genetic material from
      embryonic kidney cells and human adeno-virus. If I had the
      ability to recall ten thousand abbreviations for the amino
      acid sequence, plus hundreds of complex combinations of
      ACTG (adeneine, cytosine, thymine, guanine) I'd describe the
      structure to you. For those curious scientists, do a google
      search with the keywords 'Senomyx and patents' and the
      third link (bioportfolio.com) will provide more info than you
      need to know. See: United States Patent #5,993,778.

      How far into the future will these new biotech wonders appear
      in our food supply?

      The future is now. The next time you read "artificial flavor"
      on a food label, pause to consider what you've read here today.
      Content labels should read: Embryonic kidney cells from
      aborted human fetuses.

      Senomyx is presently developing new products with many of
      the world's largest food manufacturers including Kraft,
      Campbell's, and Coca Cola. In fact, if you eat Nestle's foods,
      your taste buds are being artificially stimulated by biotech
      products developed by Senomyx. You may not know exactly what
      you are eating, but I take this opportunity to paraphrase 17th
      century author Miguel Cervantes, who wrote in Don Quixote:

      "The proof is in the pudding."

      Robert Cohen
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