Blood xfusions ref #3
- Ann Intern Med 1993 Jul 1;119(1):8-15
Transfusion history and cancer risk in older women.
Cerhan JR, Wallace RB, Folsom AR, Potter JD, Munger RG, Prineas RJ
University of Minnesota School of Public Health, Minneapolis.
OBJECTIVE: To test the hypothesis that history of blood transfusion is
associated with an increased incidence of cancer in
older women. DESIGN: Prospective cohort study. SETTING: General
community in the state of Iowa. PARTICIPANTS:
Random sample of 37,337 cancer-free Iowa women ages 55 to 69
years. MEASUREMENTS: Transfusion history was
assessed with a mailed questionnaire completed in January 1986.
Cancer incidence in 5 years was ascertained by a
population-based cancer registry. RESULTS: Women who had ever
received a blood transfusion were at an increased risk for
non-Hodgkin lymphoma (relative risk (RR) = 2.20; 95% CI, 1.35 to 3.58)
and kidney cancer (RR = 2.53; CI, 1.34 to 4.78).
The relative risks for these cancers were greater with decreasing time
from first transfusion. No increased risk occurred for
cancers of the breast, lung, uterine corpus, ovary, pancreas, colon,
rectum, skin (melanoma), or for all cancers considered
together. CONCLUSION: These findings suggest that previous blood
transfusion may be a risk factor for non-Hodgkin
lymphoma and kidney cancer but is not associated with the most