Paclitaxel and Taxanes
- Hello all,
A subscriber on here heard from her oncologist about taxane trials and
wondered if it was the same as paclitaxel. Below is an article I found from:
Paclitacel and various taxanes are currently under investigation for their
antitumor capacity and efficacy in treating various forms or cancer.
Historically, paclitaxel has been extracted from the bark, leaves, and wood
of Taxus brevifolia. Because of the relatively limited supply of paclitaxel
this source, alternate sources of paclitaxel and other taxanes is of great
University of California researchers have been successful in culturing
haploid cells and their derivatives to produce paclitacel, related taxanes,
and other metabolites that evolve from the isoprenoid biosynthesis pathway.
From cell culture lines of haploid origin, novel cell and tissue types, not
found in nature, are regenerated and preprogrammed for the production of
taxanes, and other metabolites. The used of haploid lines is advantageous
for several reasons. Use of haploid lines removes cells that contain lethal
genes because all alleles are expressed. This technological clean-up
removes the lethal growth-inhibiting factors inherent in sporophytic genotypes
and provides superior cell lines for cell and tissue culture of taxanes.
Additionally, haploid lines offer the opportunity for cell and tissue
engineering through point mutations and genetic engineering. At
the cellular level, large numbers of genetic variants generated by
mutagenesis can be rapidly screened for desired characteristics. The
potential for amplified production of paclitaxel and related products from
cell lines derived from haploid cells also exists.
The Regents of the University of California is seeking a licensee to bring
this technology into commercial use. For further information please contact
the agent listed below.
INQUIRIES TO: Robert E. Fissell Bob.Fissell@...
REFERENCE: UC Case 92-082
PATENT STATUS: U.S. patent #5,547,866 issued August 20, 1996.
University of California
Office of Technology Transfer
1320 Harbor Bay Parkway, Suite 150
Alameda, CA 94502
Phone: (510) 748-6600 Fax: (510) 748-6639