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Key Protein Help Newts Regrow Limbs

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  • gildacabral
    LONDON (Reuters) - Scientists have found a key protein that helps newts regrow severed limbs and which may guide future research into human regenerative
    Message 1 of 1 , Nov 1, 2007
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      LONDON (Reuters) - Scientists have found a key protein that helps
      newts regrow severed limbs and which may guide future research into
      human regenerative medicine.


      Biologists have long been intrigued by the ability of newts and
      salamanders to renew damaged body parts. But how they do it has been
      unclear.

      Now new research by a British team published on Thursday shows that
      a protein called nAG, secreted by nerve and skin cells, plays a
      central role in producing a clump of immature cells, known as a
      blastema, which regrows the missing part.

      The importance of nAG was demonstrated by the fact that even when a
      nerve was severed below the stump tip, which would normally prevent
      regrowth, the scientists were able to coax regeneration by
      artificially making cells produce the protein.

      Anoop Kumar and colleagues from University College London (UCL),
      writing in the journal Science, said the finding "may hold promise
      for future efforts to promote limb regeneration in mammals."

      David Stocum of Indiana University-Purdue University Indianapolis
      said it could help explain why mammals have limited regrowth
      abilities and thus help direct the field of regenerative medicine.

      IMPORTANT STEP FORWARD

      A clear understanding of the molecular signals involved in blastema
      formation and limb regeneration could eventually allow medics to
      program similar patterns into cells of non-regenerating body parts.

      "How soon this might be possible, particularly in humans, is
      anyone's guess but the addition of nAG to the repertoire of
      necessary factors is an important step forward," Stocum said.

      In effect, newts are able to manipulate their bodies by turning
      cells into undifferentiated stem cells and then back into mature
      tissue again.

      It is a clever trick -- but understanding how they do it does not
      mean humans will necessarily be able to copy them and regrow lost
      arms or legs, according to Jeremy Brockes of UCL.

      "It would be very desirable for regenerative medicine to understand
      the specification of the blastema and to try to recreate that in a
      mammalian context. But we are a long way away from being able to do
      that," he said in an interview.

      Regenerative medicine is a growing area of research, with much of it
      centered on stem cells, the master cells that act as a source for
      various cells and tissues in the body.
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