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First Time Science Admits Bacteria Can Lead To Cancer

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  • Robert Sterling
    Please send as far and wide as possible. Thanks, Robert Sterling Editor, The Konformist http://www.konformist.com First Time Science Admits Bacteria Can Lead
    Message 1 of 1 , Oct 9 2:40 PM
      Please send as far and wide as possible.

      Robert Sterling
      Editor, The Konformist

      First Time Science Admits Bacteria Can Lead To Cancer
      Alan Cantwell MD

      The 2005 Nobel Prize in Physiology or Medicine for BACTERIA as a

      Has been awarded to: Barry Marshall and Robin Warren from Australia.

      This is the first recognition (via a Nobel Prize) that BACTERIA can
      lead to CANCER!! Of course, this idea has been "medical heresy" for
      more than a century.

      Perhaps someday physicians will recognize the fact that BACTERIA are
      involved in MANY FORMS OF CANCER (see the work of "FOUR WOMEN"

      Alan Cantwell MD

      The 2005 Nobel Prize in Physiology or Medicine

      The Nobel Assembly at Karolinska Institutet has today decided to
      award The Nobel Prize in Physiology or Medicine for 2005 jointly to
      Barry J. Marshall and J. Robin Warren for their discovery of "the
      bacterium Helicobacter pylori and its role in gastritis and peptic
      ulcer disease"


      This year's Nobel Laureates in Physiology or Medicine made the
      remarkable and unexpected discovery that inflammation in the stomach
      (gastritis) as well as ulceration of the stomach or duodenum (peptic
      ulcer disease) is the result of an infection of the stomach caused
      by the bacterium Helicobacter pylori.

      Robin Warren (born 1937), a pathologist from Perth, Australia,
      observed small curved bacteria colonizing the lower part of the
      stomach (antrum) in about 50% of patients from which biopsies had
      been taken. He made the crucial observation that signs of
      inflammation were always present in the gastric mucosa close to
      where the bacteria were seen.

      Barry Marshall (born 1951), a young clinical fellow, became
      interested in Warren's findings and together they initiated a study
      of biopsies from 100 patients. After several attempts, Marshall
      succeeded in cultivating a hitherto unknown bacterial species (later
      denoted Helicobacter pylori) from several of these biopsies.
      Together they found that the organism was present in almost all
      patients with gastric inflammation, duodenal ulcer or gastric ulcer.
      Based on these results, they proposed that Helicobacter pylori is
      involved in the aetiology of these diseases.

      Even though peptic ulcers could be healed by inhibiting gastric acid
      production, they frequently relapsed, since bacteria and chronic
      inflammation of the stomach remained. In treatment studies, Marshall
      and Warren as well as others showed that patients could be cured
      from their peptic ulcer disease only when the bacteria were
      eradicated from the stomach. Thanks to the pioneering discovery by
      Marshall and Warren, peptic ulcer disease is no longer a chronic,
      frequently disabling condition, but a disease that can be cured by a
      short regimen of antibiotics and acid secretion inhibitors.

      Peptic ulcer -- an infectious disease!

      This year's Nobel Prize in Physiology or Medicine goes to Barry
      Marshall and Robin Warren, who with tenacity and a prepared mind
      challenged prevailing dogmas. By using technologies generally
      available (fibre endoscopy, silver staining of histological sections
      and culture techniques for microaerophilic bacteria), they made an
      irrefutable case that the bacterium Helicobacter pylori is causing
      disease. By culturing the bacteria they made them amenable to
      scientific study.

      In 1982, when this bacterium was discovered by Marshall and Warren,
      stress and lifestyle were considered the major causes of peptic
      ulcer disease. It is now firmly established that Helicobacter pylori
      causes more than 90% of duodenal ulcers and up to 80% of gastric
      ulcers. The link between Helicobacter pylori infection and
      subsequent gastritis and peptic ulcer disease has been established
      through studies of human volunteers, antibiotic treatment studies
      and epidemiological studies.

      Helicobacter pylori causes life-long infection

      Helicobacter pylori is a spiral-shaped Gram-negative bacterium that
      colonizes the stomach in about 50% of all humans. In countries with
      high socio-economic standards infection is considerably less common
      than in developing countries where virtually everyone may be

      Infection is typically contracted in early childhood, frequently by
      transmission from mother to child, and the bacteria may remain in
      the stomach for the rest of the person's life. This chronic
      infection is initiated in the lower part of the stomach (antrum). As
      first reported by Robin Warren, the presence of Helicobacter pylori
      is always associated with an inflammation of the underlying gastric
      mucosa as evidenced by an infiltration of inflammatory cells.

      The infection is usually asymptomatic but can cause peptic ulcer

      The severity of this inflammation and its location in the stomach is
      of crucial importance for the diseases that can result from
      Helicobacter pylori infection. In most individuals Helicobacter
      pylori infection is asymptomatic. However, about 10-15% of infected
      individuals will some time experience peptic ulcer disease. Such
      ulcers are more common in the duodenum than in the stomach itself.
      Severe complications include bleeding and perforation.

      The current view is that the chronic inflammation in the distal part
      of the stomach caused by Helicobacter pylori infection results in an
      increased acid production from the non-infected upper corpus region
      of the stomach. This will predispose for ulcer development in the
      more vulnerable duodenum.

      Malignancies associated with Helicobacter pylori infection

      In some individuals Helicobacter pylori also infects the corpus
      region of the stomach. This results in a more widespread
      inflammation that predisposes not only to ulcer in the corpus
      region, but also to stomach cancer. This cancer has decreased in
      incidence in many countries during the last half-century but still
      ranks as number two in the world in terms of cancer deaths.

      Inflammation in the stomach mucosa is also a risk factor for a
      special type of lymphatic neoplasm in the stomach, MALT (mucosa
      associated lymphoid tissue) lymphoma. Since such lymphomas may
      regress when Helicobacter pylori is eradicated by antibiotics, the
      bacterium plays an important role in perpetuating this tumour.

      Disease or not -- interaction between the bacterium and the human

      Helicobacter pylori is present only in humans and has adapted to the
      stomach environment. Only a minority of infected individuals develop
      stomach disease. After Marshall's and Warren's discovery, research
      has been intense. Details underlying the exact pathogenetic
      mechanisms are continuously being unravelled.

      The bacterium itself is extremely variable, and strains differ
      markedly in many aspects, such as adherence to the gastric mucosa
      and ability to provoke inflammation. Even in a single infected
      individual all bacteria are not identical, and during the course of
      chronic infection bacteria adapt to the changing conditions in the
      stomach with time.

      Likewise, genetic variations among humans may affect their
      susceptibility to Helicobacter pylori. Not until recently has an
      animal model been established, the Mongolian gerbil. In this animal,
      studies of peptic ulcer disease and malignant transformation promise
      to give more detailed information on disease mechanisms.

      Antibiotics cure but can lead to resistance

      Helicobacter pylori infection can be diagnosed by antibody tests, by
      identifying the organism in biopsies taken during endoscopy, or by
      the non-invasive breath test that identifies bacterial production of
      an enzyme in the stomach.

      An indiscriminate use of antibiotics to eradicate Helicobacter
      pylori also from healthy carriers would lead to severe problems with
      bacterial resistance against these important drugs. Therefore,
      treatment against Helicobacter pylori should be used restrictively
      in patients without documented gastric or duodenal ulcer disease.

      Microbial origin of other chronic inflammatory conditions?

      Many diseases in humans such as Crohn's disease, ulcerative colitis,
      rheumatoid arthritis and atherosclerosis are due to chronic
      inflammation. The discovery that one of the most common diseases of
      mankind, peptic ulcer disease, has a microbial cause, has stimulated
      the search for microbes as possible causes of other chronic
      inflammatory conditions.

      Even though no definite answers are at hand, recent data clearly
      suggest that a dysfunction in the recognition of microbial products
      by the human immune system can result in disease development. The
      discovery of Helicobacter pylori has led to an increased
      understanding of the connection between chronic infection,
      inflammation and cancer.


      Alan Cantwell MD

      Bacteria, Cancer and the Origin of Life
      Cantwell, Alan. 2005
      Aries Rising Press, Los Angeles, CA

      Back in the 1950s a group of four women scientists began to work
      together to uncover the microbiology of cancer. Rather than being
      received with enthusiasm, their published cancer research was
      largely ignored or overlooked. In this highly controversial book,
      Alan Cantwell, MD, presents the revolutionary cancer research of
      physician Virginia Livingston, MD; microbiologist Eleanor Alexander-
      Jackson; cell cytologist Irene Diller; and world-famous biochemist
      Florence Seibert - all of whom discovered an easily detectable
      bacterial agent in cancer -a microbe whose existence is still
      totally denied by the medical establishment. Unlike any infectious
      agent known to science, the cancer microbe has characteristics of
      both bacteria and viruses-and produces a remarkable hormone that
      allows life to continually reproduce and renew itself. This book
      should prove of interest to readers who want to learn more about the
      bacteriology of cancer, and how this knowledge could prove useful in
      the conquest of cancer.
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