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Fwd: Researchers Discover Additional Benefit of Vitamin A

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  • Rajesh Kumar Sood
    ... From: Office of Communications Date: Thu, May 13, 2010 at 2:32 AM Subject: Researchers Discover Additional Benefit of Vitamin A To:
    Message 1 of 3 , May 12, 2010


      ---------- Forwarded message ----------
      From: Office of Communications <paffairs@...>
      Date: Thu, May 13, 2010 at 2:32 AM
      Subject: Researchers Discover Additional Benefit of Vitamin A
      To: drrksood@...


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      Public Health News
      For Immediate Release: May 12, 2010
      Media Contact: Natalie Wood-Wright at 410-955-6878
      Researchers Discover Additional Benefit of Vitamin A

      Vitamin A is critical to maternal health and child survival, yet in most developing countries Vitamin A deficiency is a leading cause of blindness and increased child mortality. The Johns Hopkins Bloomberg School of Public Health has long been a leader in vitamin A research, and scientists at the School recently discovered a link between offspring lung function and maternal vitamin A supplementation. The results are published in the May 13, 2010, issue of the New England Journal of Medicine.

      “Children of mothers who received vitamin A supplementation before, during and after pregnancy had significantly improved lung function when compared to those whose mothers received beta-carotene supplementation or placebo,” said lead author of the study, William Checkley, MD, PhD, assistant professor in the Division of Pulmonary and Critical Care of the Johns Hopkins School of Medicine with a joint appointment in the Bloomberg School’s Department of International Health. “Lung function of offspring in mothers who received maternal vitamin A supplementation improved by about 40 ml versus those whose mothers received a placebo. This represents an approximately 3 percent increase in lung function. Furthermore, the magnitude of effect observed in this study is slightly greater than that associated with preventing exposure to parental smoking in school-age children.”

      Vitamin A deficiency affects nearly 190 million preschool-age children worldwide and is the underlying cause of 650,000 early childhood deaths annually. To examine the effect of antenatal vitamin A supplementation on lung function, researchers revisited a cohort of children ages 9 to 13 in rural Nepal whose mothers were randomized to receive vitamin A, beta-carotene or a placebo. Using a portable pneumatochometer, offspring lung function was measured. They found that children whose mothers received vitamin A instead of a placebo had a significantly greater forced expiratory volume at one second (FEV1) and a greater forced vital capacity (FVC), while children whose mothers received beta-carotene instead of a placebo had similar FEV and FVC.

      “Improved lung function was likely specific to supplementation received in utero because this population of children was subsequently exposed beyond six months of age to semiannual vitamin A supplementation with high coverage as part of a national program during their preschool years,” said Keith West, DrPH, MPH, George G. Graham Professor in Infant and Child Nutrition in the Bloomberg School’s Department of International Health. “This benefit was limited to children whose mothers received vitamin A and not to those whose mothers received beta-carotene. Early interventions with vitamin A in communities where undernutrition is highly prevalent may have long-lasting consequences in lung health.”

      Vitamin A was first discovered in 1913 by E.V. McCollum, the founding chair of the School’s Department of Chemical Hygiene, now Biochemistry and Molecular Biology. It was one of the first essential micronutrients to be identified. In the 1970s, Alfred Sommer, MD, MHS, dean emeritus at the Bloomberg School of Public Health, and colleagues discovered the link between vitamin A deficiency and night blindness among children in rural Indonesia and found that vitamin A given twice a year reduced childhood mortality by a third. The World Bank declared vitamin A supplementation as one of the most cost-effective medical interventions of all time.

      “Maternal Vitamin A Supplementation Before, During and After Pregnancy Improves Lung Function in Preadolescent Offspring” was written by William Checkley, Keith P West Jr., Robert A Wise, Matthew R Baldwin, Steven C LeClerq, Parul Christian, Joanne Katz, James Tielsch, Subarna Kharty and Alfred Sommer.

      The current study was supported by the Bill & Melinda Gates Foundation (Seattle, Wash.) and the Sight and Life Research Institute (Baltimore, Md). The original maternal supplementation trial was supported by the U.S. Agency for International Development (Washington, D.C.). William Checkley was further supported by a Clinician Scientist Award from the Johns Hopkins University and a K99/R00 Pathway to Independence Award from the National Institutes of Health.

      For public health news updated throughout the day, visit our Public Health News Center.

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      © 2010, Johns Hopkins University, all rights reserved.
      Web policies, 615 N. Wolfe Street, Baltimore MD 21205-2179, 410-955-6878




      --
      Dr RK Sood
      District AIDS Project Officer Kangra
      # 402 C ZH Dharamshala,
      District Kangra Himachal Pradesh, India
      Mobile: +91 9418064077
      Telefax:  +91 1892- 225559
      drrksood@...
    • Prof. Umesh Kapil
      Dear All   Universal  Vitamin A ( VA) supplementaion  was till recently promoted for i) prevention of nutritional blindness due  to VA deficiency and ii)
      Message 2 of 3 , May 12, 2010
        Dear All
         
        Universal  Vitamin A ( VA) supplementaion  was till recently promoted for i) prevention of nutritional blindness due  to VA deficiency and ii) reduction in under five mortality. Now both these issues are highly  debatable in view of the recent scientific evidence produced.
         
         
        The new findings of  " a link between offspring lung function and maternal vitamin A supplementation " is  another   interesting scientific evidence   for promoting universal VA supplementation to children in developing  countries.
         
         
        Regards
         
        Umesh
         
         

         
        Dr. Umesh Kapil,
        Professor , Public Health Nutrition,
        All India Institute of Medical Sciences ,
        New Delhi, 110029,
        India
        Mobile : 9810609340,
        Office 26593383
        Res: 26195105


        --- On Wed, 5/12/10, Rajesh Kumar Sood <drrksood@...> wrote:

        From: Rajesh Kumar Sood <drrksood@...>
        Subject: [iapsm_youthmembers] Fwd: Researchers Discover Additional Benefit of Vitamin A
        To: iapsm_youthmembers@yahoogroups.com, "ifanet india" <ifanet-india@...>, mfriendcircle@yahoogroups.com
        Date: Wednesday, May 12, 2010, 10:50 PM

         
        ---------- Forwarded message ---------- From: Office of Communications Date: Thu, May 13, 2010 at 2:32 AM Subject: Researchers Discover Additional Benefit of Vitamin A To: drrksood@gmail. com Subscribe Email to a Colleague Public Health News *For Immediate Release: May 12, 2010 Media Contact: Natalie Wood-Wright at 410-955-6878* Researchers Discover Additional Benefit of Vitamin A Vitamin A is critical to maternal health and child survival, yet in most developing countries Vitamin A deficiency is a leading cause of blindness and increased child mortality. The Johns Hopkins Bloomberg School of Public Health has long been a leader in vitamin A research, and scientists at the School recently discovered a link between offspring lung function and maternal vitamin A supplementation. The results are published in the May 13, 2010, issue of the New England Journal of Medicine. “Children of mothers who received vitamin A supplementation before, during and after pregnancy had significantly improved lung function when compared to those whose mothers received beta-carotene supplementation or placebo,” said lead author of the study, William Checkley, MD, PhD, assistant professor in the Division of Pulmonary and Critical Care of the Johns Hopkins School of Medicine with a joint appointment in the Bloomberg School’s Department of International Health. “Lung function of offspring in mothers who received maternal vitamin A supplementation improved by about 40 ml versus those whose mothers received a placebo. This represents an approximately 3 percent increase in lung function. Furthermore, the magnitude of effect observed in this study is slightly greater than that associated with preventing exposure to parental smoking in school-age children.” Vitamin A deficiency affects nearly 190 million preschool-age children worldwide and is the underlying cause of 650,000 early childhood deaths annually. To examine the effect of antenatal vitamin A supplementation on lung function, researchers revisited a cohort of children ages 9 to 13 in rural Nepal whose mothers were randomized to receive vitamin A, beta-carotene or a placebo. Using a portable pneumatochometer, offspring lung function was measured. They found that children whose mothers received vitamin A instead of a placebo had a significantly greater forced expiratory volume at one second (FEV1) and a greater forced vital capacity (FVC), while children whose mothers received beta-carotene instead of a placebo had similar FEV and FVC. “Improved lung function was likely specific to supplementation received in utero because this population of children was subsequently exposed beyond six months of age to semiannual vitamin A supplementation with high coverage as part of a national program during their preschool years,” said Keith West, DrPH, MPH, George G. Graham Professor in Infant and Child Nutrition in the Bloomberg School’s Department of International Health. “This benefit was limited to children whose mothers received vitamin A and not to those whose mothers received beta-carotene. Early interventions with vitamin A in communities where undernutrition is highly prevalent may have long-lasting consequences in lung health.” Vitamin A was first discovered in 1913 by E.V. McCollum, the founding chair of the School’s Department of Chemical Hygiene, now Biochemistry and Molecular Biology. It was one of the first essential micronutrients to be identified. In the 1970s, Alfred Sommer, MD, MHS, dean emeritus at the Bloomberg School of Public Health, and colleagues discovered the link between vitamin A deficiency and night blindness among children in rural Indonesia and found that vitamin A given twice a year reduced childhood mortality by a third. The World Bank declared vitamin A supplementation as one of the most cost-effective medical interventions of all time. “Maternal Vitamin A Supplementation Before, During and After Pregnancy Improves Lung Function in Preadolescent Offspring” was written by William Checkley, Keith P West Jr., Robert A Wise, Matthew R Baldwin, Steven C LeClerq, Parul Christian, Joanne Katz, James Tielsch, Subarna Kharty and Alfred Sommer. The current study was supported by the Bill Melinda Gates Foundation (Seattle, Wash.) and the Sight and Life Research Institute (Baltimore, Md). The original maternal supplementation trial was supported by the U.S. Agency for International Development (Washington, D.C.). William Checkley was further supported by a Clinician Scientist Award from the Johns Hopkins University and a K99/R00 Pathway to Independence Award from the National Institutes of Health. For public health news updated throughout the day, visit our Public Health News Center . If you find this information useful, please forward it to a friend or colleague. If you have received this message in error or wish to unsubscribe, please click here to manage your subscriptions. © 2010, Johns Hopkins University, all rights reserved. Web policies , 615 N. Wolfe Street, Baltimore MD 21205-2179, 410-955-6878 -- Dr RK Sood District AIDS Project Officer Kangra # 402 C ZH Dharamshala, District Kangra Himachal Pradesh, India Mobile: +91 9418064077 Telefax: +91 1892- 225559 drrksood@gmnail. com

      • Dr. Karan Singh Sagar
        Attached is the World Health Statistics 2010 report by WHO Best Regards Dr. Karan Singh Sagar
        Message 3 of 3 , May 16, 2010

           

          Attached is the World Health Statistics 2010 report by WHO

           

          Best Regards

          Dr. Karan Singh Sagar

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