Re: New Possible HIV Treatment!
- --- In firstname.lastname@example.org, "R. Mitchell Deighan"
> hey guys, hope this isn1t considered off topic...COOL!!! No more toxic cocktails?
> it was extremely exciting to just hear about this possibly monumental
> medical breakthrough!!:
> (ps: last night, I heard this reported on our local FOX affiliate,
> WTXF-TV29, here in Philly)
> Discovery 'Can Destroy HIV' Researchers Claim
> by The Associated Press
> Posted: December 13, 2004 2:02 pm ET
> (Piscataway, New Jersey) Researchers at Rutgers University say they
> have developed a trio of drugs they believe can destroy HIV, the
> virus that causes AIDS.
> The drugs, called DAPYs, mimic the virus by changing shape, which
> enables them to interfere with the way HIV attacks the immune system.
> Tests conducted in conjunction with Johnson and Johnson have shown
> the drug to be easily absorbed with minimal side effects. It also can
> be taken in one pill, in contrast to the drug cocktails currently
> taken by many AIDS patients.
> "This could be it," Stephen Smith, the head of the department of
> infectious diseases at Saint Michael's Medical Center in Newark, told
> The Sunday Star-Ledger of Newark. "We're all looking for the next
> class of drugs."
> A research team led by Rutgers chemist Eddy Arnold pre-published
> details of the most promising of the three drugs, known as R278474,
> last month in the electronic edition of the Journal of Medicinal
> Chemistry. Full details will be published in the journal in early
> Arnold, 47, has worked at dismantling the AIDS virus over the last 20
> years. He uses X-ray crystallography, a technique to determine the
> structure of molecules, the smallest particles that can retain all
> the characteristics of an element or compound.
> The research has targeted reverse transcriptase, a submiscroscopic
> protein composed of two coiled chains of amino acids. It is
> considered HIV's key protein.
> "Reverse transcriptase is very important in the biology of AIDS,"
> Smith said. "If you can really inhibit reverse transcriptase, you can
> stop AIDS."
> The optimism about R278474 stems from its potential to interfere with
> an enzyme that the virus needs to copy and insert itself into a human
> "We're onto something very, very special," Arnold told the newspaper.
> Arnold established his lab at Rutgers' Center for Advanced
> Biotechnology and Medicine in 1987. His current 30-member research
> team is partnered with Johnson and Johnson subsidiaries Janssen
> Pharmaceutica and Tibotec-Virco NV.
> An important advancement in Arnold's research came in 1990 when
> Belgian scientist Paul Janssen was added to the collaboration.
> Janssen, considered a drug pioneer, published a paper that year that
> described a new drug that blocked reverse transcriptase but caused
> resistant strains of the virus to pop up too quickly.
> Janssen sought out Arnold, who used crystallography to detail the
> structure of RT. Their work ultimately led to the RT inhibitors.
> Two earlier relatives of R278474, called TMC-120 and TMC-125, have
> showed promise in clinical trials. Johnson and Johnson officials told
> the newspaper that the two drugs are of major interest to them, but
> did not discuss R278474.
> "We may eventually win the war against HIV/AIDS. That would be an
> extremely rewarding and satisfying outcome," Arnold said. "But even
> to have contributed to helping the health and well-being of the many
> people infected with HIV will be very satisfying if that were to
> ©Associated Press 2004
I wish I knew more abpout the so-called "zappers" - they are said to be good.