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Re: New Possible HIV Treatment!

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  • yank_canuck
    ... COOL!!! No more toxic cocktails? I wish I knew more abpout the so-called zappers - they are said to be good. http://www.zapperplans.com/plans.html
    Message 1 of 2 , Dec 19, 2004
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      --- In gaykingdom@yahoogroups.com, "R. Mitchell Deighan"
      <mitch.deighan@v...> wrote:
      > hey guys, hope this isn1t considered off topic...
      > it was extremely exciting to just hear about this possibly monumental
      > medical breakthrough!!:
      > Mitch
      > (ps: last night, I heard this reported on our local FOX affiliate,
      > WTXF-TV29, here in Philly)
      >
      > Discovery 'Can Destroy HIV' Researchers Claim
      > by The Associated Press
      > Posted: December 13, 2004 2:02 pm ET
      >
      > (Piscataway, New Jersey) Researchers at Rutgers University say they
      > have developed a trio of drugs they believe can destroy HIV, the
      > virus that causes AIDS.
      >
      > The drugs, called DAPYs, mimic the virus by changing shape, which
      > enables them to interfere with the way HIV attacks the immune system.
      >
      > Tests conducted in conjunction with Johnson and Johnson have shown
      > the drug to be easily absorbed with minimal side effects. It also can
      > be taken in one pill, in contrast to the drug cocktails currently
      > taken by many AIDS patients.
      >
      > "This could be it," Stephen Smith, the head of the department of
      > infectious diseases at Saint Michael's Medical Center in Newark, told
      > The Sunday Star-Ledger of Newark. "We're all looking for the next
      > class of drugs."
      >
      > A research team led by Rutgers chemist Eddy Arnold pre-published
      > details of the most promising of the three drugs, known as R278474,
      > last month in the electronic edition of the Journal of Medicinal
      > Chemistry. Full details will be published in the journal in early
      > 2005.
      >
      > Arnold, 47, has worked at dismantling the AIDS virus over the last 20
      > years. He uses X-ray crystallography, a technique to determine the
      > structure of molecules, the smallest particles that can retain all
      > the characteristics of an element or compound.
      >
      > The research has targeted reverse transcriptase, a submiscroscopic
      > protein composed of two coiled chains of amino acids. It is
      > considered HIV's key protein.
      >
      > "Reverse transcriptase is very important in the biology of AIDS,"
      > Smith said. "If you can really inhibit reverse transcriptase, you can
      > stop AIDS."
      >
      > The optimism about R278474 stems from its potential to interfere with
      > an enzyme that the virus needs to copy and insert itself into a human
      > cell.
      >
      > "We're onto something very, very special," Arnold told the newspaper.
      >
      > Arnold established his lab at Rutgers' Center for Advanced
      > Biotechnology and Medicine in 1987. His current 30-member research
      > team is partnered with Johnson and Johnson subsidiaries Janssen
      > Pharmaceutica and Tibotec-Virco NV.
      >
      > An important advancement in Arnold's research came in 1990 when
      > Belgian scientist Paul Janssen was added to the collaboration.
      > Janssen, considered a drug pioneer, published a paper that year that
      > described a new drug that blocked reverse transcriptase but caused
      > resistant strains of the virus to pop up too quickly.
      >
      > Janssen sought out Arnold, who used crystallography to detail the
      > structure of RT. Their work ultimately led to the RT inhibitors.
      >
      > Two earlier relatives of R278474, called TMC-120 and TMC-125, have
      > showed promise in clinical trials. Johnson and Johnson officials told
      > the newspaper that the two drugs are of major interest to them, but
      > did not discuss R278474.
      >
      > "We may eventually win the war against HIV/AIDS. That would be an
      > extremely rewarding and satisfying outcome," Arnold said. "But even
      > to have contributed to helping the health and well-being of the many
      > people infected with HIV will be very satisfying if that were to
      > happen."
      >
      > ©Associated Press 2004

      COOL!!! No more toxic cocktails?
      I wish I knew more abpout the so-called "zappers" - they are said to be good.
      http://www.zapperplans.com/plans.html
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