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Compound f rom mold l inked to s ymptoms of Parkinson ’s disease

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  • Andrew Cutz
    Compound from mold linked to symptoms of ParkinsonÆs disease NIEHS grantees report that an organic compound emitted by mold might be linked to Parkinson s and
    Message 1 of 1 , Feb 5, 2014
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      Compound from mold linked to symptoms of Parkinson’s disease

      NIEHS grantees report that an organic compound emitted by mold might be linked to Parkinson's and other neurodegenerative diseases in humans. Studies have found evidence that several environmental agents, especially pesticides, are possible risk factors for Parkinson’s disease, but this is the first naturally occurring environmental agent identified as a potential risk factor.

      Exposure to fungi has been linked to movement disorders, as well as loss of balance and coordination, but the mechanisms involved in these health effects are unknown. To find out more about the possible toxicological effects of fungal volatile organic compounds associated with indoor environments, the researchers screened a variety of fungal toxicants using fruit flies. The volatile fungal semiochemical 1-octen-3-ol emerged as one of the most potent agents they tested.  1-octen-3-ol is commonly emitted by molds and is responsible for much of the moldy odor associated with fungal colonization.

      Parkinson’s disease is associated with the loss of neurons that produce the neurotransmitter dopamine. The researchers found that low levels of 1-octen-3-ol reduced dopamine levels and caused dopamine neuron degeneration in the fruit flies. Genetic and cell culture studies revealed that 1-octen-3-ol most likely exerts toxicity by disrupting dopamine handling. The agent also increased loss of dopaminergic neurons through interactions with genetic variants of the vesicular monoamine transporter, which is involved in dopamine biosynthesis. 

      CitationInamdar AA, Hossain MM, Bernstein AI, Miller GW, Richardson JR, Bennett JW.   2013. Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration. Proc Natl Acad Sci U S A 110(48):19561-19566.

      URL:  http://www.ncbi.nlm.nih.gov/pubmed/24218591


      SOURCE:   U.S. NIEHS Environmental Factor - February 2014  |   http://www.niehs.nih.gov/news/newsletter/2014/2/dert/index.htm#a2


      END   Forwarded by Andrew Cutz, CIH, AIHA Fellow  |  Moderator, Flood Relief Aid List 

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