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feline cardiomyopathy:Types

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  • Westgold
    Hi -- someone posted this on another list -- from Dr Kittleson From Dr. Kittleson: In a message dated 8/26/2010 7:49:26 A.M. Pacific Daylight Time,
    Message 1 of 1 , Aug 27 10:35 PM
      Hi -- someone posted this on another list -- from Dr Kittleson


      From Dr. Kittleson:

      In a message dated 8/26/2010 7:49:26 A.M. Pacific Daylight Time,
      mdkittleson@... writes:

      There's only one HCM. It's manifested in many different ways with regard
      to the distribution of the hypertrophy. So that's the phenotypic story. With
      regard to genes, there are 11 genes that have mutations in them that code
      for proteins in the sarcomere and a couple of other oddball genes in
      humans. Amongst these genes there are now over 1000 mutations identified in
      humans but the majority of those mutations are in myosin binding protein C and
      beta myosin heavy chain. So far two mutations in myosin binding protein C
      have been identified in cats. So that may be considered the tip of the
      iceberg in all of catdom but in Ragdolls this one mutation is likely to be the
      whole story and in Maine Coons there is probably one more and there could be
      a couple more mutations responsible for HCM in the breed. So I don't see
      this as being a tip of an iceberg in these two breeds.

      Mark D. Kittleson, DVM, PhD
      Diplomate ACVIM (Cardiology)
      Professor, Dept. of Medicine and Epi.
      School of Veterinary Medicine
      UCDavis




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