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Re: [FH] Need some advice for Snowball please

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  • savionna@aol.com
    Hi Carol, ... What does Snowball eat? I m asking b/c that would have an effect on the bowel inflammation and pancreatitis, which would have an effect on the
    Message 1 of 40 , Mar 1, 2008
      Hi Carol,

      In a message dated 3/1/08 11:13:55 AM, carolroars@... writes:

      > I haven't really posted much for Snowball. She's my
      > CRF/HCM/IBD/Pancreatitis kitty.
      > Last October Snowball was diangosed with IBD, pancreatitis,
      > and hyperthyroid.
      What does Snowball eat? I'm asking b/c that would have an effect on the bowel
      inflammation and pancreatitis, which would have an effect on the nausea and
      appetite. (I understand she's not eating...but what has she shown interest in
      or what was she eating previously?)

      Also...how is the pancreatitis being managed? Is Snowball on animal-source
      pancreatic enzymes? Which homeopathics have you used...eg, Iris versicolor is
      one that fits the symptom picture of pancreatitis.

      How is the bowel inflammation being managed? Some options besides injectable
      B12 (if you haven't considered them already) incl L-glutamine, Standard
      Process Feline Enteric Support, and slippery elm bark.

      Is Snowball on Tap? Is the dose adjusted for the thyroid and kidneys? Tap has
      a reputation for causing nausea as well as liver problems (and liver problems
      often go hand-in-hand with bowel inflammation and pancreatitis). Have you
      considered using milk thistle to help reduce the potential problems with Tap on
      the liver?

      I understand this is a lot to manage at once...and no one remedy is going to
      solve all the problems. But I'm trying to think of ways to reduce some of the
      factors contributing to the nausea.

      > She walks up
      > to the food like she's hungry, but just jumps away from it like it's
      > got cooties or something!
      That's typical of nausea...and Tap, pancreatitis, and bowel inflammation are
      all involved with nausea.

      > Is this reaction common with Reglan?
      Not common but certainly known.

      1. From Merck Vet Manual at

      "Metoclopramide readily crosses the blood-brain barrier, where dopamine
      antagonism at the CTZ produces an antiemetic effect. However, dopamine antagonism
      in the striatum causes adverse effects known collectively as extrapyramidal
      signs, which include involuntary muscle spasms, motor restlessness, and
      inappropriate aggression. If recognized in time, the extrapyramidal signs can be
      reversed by restoring an appropriate dopamine:acetylcholine balance with the
      anticholinergic action of an antihistamine, such as diphenhydramine hydrochloride
      given IV at a dosage of 1.0 mg/kg."

      From Pet Place at
      http://www.petplace.com/drug-library/metoclopramide-hcl-reglan/page1.aspx : "There have been occasional reports of changes in behavior
      and mental states. Cats may become very anxious, bordering on frenzied."

      From VIN at http://www.veterinarypartner.com/Content.plx?P=A&S=0&C=0&A=523 :
      "Side effects are rare with metoclopramide but generally stem from the ability
      to penetrate the blood-brain barrier. Animals predisposed to seizures (i.e.,
      epileptics) may experience seizures, although this should not be a problem for
      normal animals. Some animals experience drowsiness and others will experience
      marked hyperactivity. Hyperactivity can be reversed with a dose of Benedryl

      > Does anyone know how long this drug stays in their systems? Is she
      > going to be like this for 12 hours? The dose on the bottle was every
      > 12 hours.
      Sorry, I can't answer those questions. We used metoclopramide (oral and inj.)
      for 2 yrs for gastroparesis...and the cat never had an adverse reaction, so I
      don't know how long it lasts.
      > I don't know what to do for her.
      Call the vet, b/c the effect can apparently be reduced with diphenhydramine.
      // Rosemary

      Ideas to please picky eaters. Watch video on AOL


      [Non-text portions of this message have been removed]
    • Carol
      hi everyone, First thank you everyone for all the help and support this past week for Snowball. I really am so very grateful for everything everyone has
      Message 40 of 40 , Jun 12, 2009
        hi everyone,

        First thank you everyone for all the help and support this past week for Snowball. I really am so very grateful for everything everyone has offered in the way of advice and sharing your experiences. I was so freaked out last weekend with how much Snowball was throwing up and she's just felt so bad all week. Forgive me, though, I haven't had time or the energy to write back to everyone personally yet, but I hope to. I'm posting this to a few groups, so sorry for any duplicates.

        We took her in for bloodwork on Monday and Tuesday she had her abdominal ultrasound, Wednesday was the cardiac ultrasound. The vets couldn't schedule everything the same day, so we had to drag poor Snowball down to the vet 3 days in a row!

        I got all the results back today, and it's not so good. I guess I knew that though. Her pancreatitis tests came back elevated again. Her Folate and Cobalamine were normal, but the fTLI and fPLI were elevated again. They were very close to normal last fall, the first time they were that way since Oct. 2007 when she first got it all going on. I'm not sure why triggered her pancreas to go bonkers again. I have a sneaking hunch that it was some of the Chinese herbs that the holistic vet gave her...not so much just taking the herbs, but that the vet had us increase them and it was just the next day after that, that Snowball started throwing up last Friday. She's still not on anything yet. She had her acupuncture on Thursday (yesterday), and the vet wants to keep her off everything (the herbs and most supplements) for a couple weeks to see how she is before introducing anything back in again.

        I do think that's a good idea, but tonight I couldn't watch Snowball being so pewey and not eating. She's lost 5 ounces since last Friday and not eating, so tonight I gave her a tiny 1/8 of a Cyproheptadine (appetite stimulant). I'm just so worried about her losing more weight. She's already looking really boney, she's lost a lot of muscle mass in just this past week alone. An hour after I gave her the Cyproheptadine, she started eating, and I know she wasn't really hungry and it was just the medication making her eat, but as long as she can keep it down, I just want her to eat so she can get her weight back again. I noticed, though, that she got really nauseated after she did eat. This was before we got the Ondansetron. Is that what happens with pancreatitis? They get nauseated every time they eat? Anyone know why that happens... the getting nauseated after eating?

        I got the Ondansetron injectible today. It's kinda strange how it came. I was expecting just one bottle, like the Pepcid injectable I get, but it was a little box with 10 little tiny vials in it, each with 2ml in it. The dose they told me was .35cc once or twice a day, subQ.

        Since she looked so pewey, this was about an hour after she had eaten, I gave her an injection as soon as Steve brought it home from the drug store. A couple hours later she seems to feel better. Thank goodness!

        I'm also giving her some Buprenex, half a dose because she goes wonky on a whole dose, every other day. Half a dose seems to stay with her for almost two days. It makes her wired though. She lays there staring out into the nothing, like she's in a trance. I was laying in bed with her next to my head on her little bed, and she's just laying there with her eyes wide open, staring at me. It was kind of weird. She did that for about two hours, before she finally closed her eyes and went to sleep.

        I also started up her Azodyl again, just once a day for now till I see if she can keep them down. I'd like to start up her CoQ10 and DMG for her heart soon.

        Her cardiac ultrasound was worse this time. She's had for the past two years no change in her heart (early stage HCM with valve regurgitation), but now the cardiologist upgraged it from "mild" to "moderate" and he's now put her on Atenolol to lower her heart rate (which is around 200 resting). He's hoping it'll lower her blood pressure too. Her BP is hovering around 180.

        I'm worried about what the Atenolol will do to her tummy. I've heard from others that it makes them throw up... just what we don't need. I'm also worried about what's going to happen with her kidneys when her blood pressure goes down.

        The other thing on the tests was that her hyperthyroid is out of control again, even on the Tapazole (transdermal cream). So the vet said to give it twice a day now instead once. She was getting 2.5mg per day, now will get 5.0. I'm worried about her kidneys with that too. I know that lowering the thyroid can have a negative effect on the kidneys, make the worse. I guess we just have to deal with whatever happens when it happens...I'm just hoping things will stay stable. Right now her BUN and Creatinine were actually better than in April. Went from BUN 73 to 47 and Creatinine in mid 3's to upper 2's. I think it's probably because her thyroid went up that her kidney values went down, and when the thyroid goes back down, her kidney values will go back up again.

        The abdominal ultrasound also showed the mass in her liver (a biliary cyst) was bigger than it was in beginning of May. :-( But now she also has another fluid cyst in her liver too. The vet said that outside of surgery, which she's not a candidate for, there's no treatment for them, and that they'll continue to grow. Eventually they'll grow large enough to start interfering with her other organs. When that happens... well, you all know what that means, and I can't even type those words.... so I won't.

        I wish that things didn't get affected by other things so much... medications affecting her adversely, one problem affecting another negatively... I wish that we could just get things stable and she could not be nauseated. You should see her when she feels good and she's not got a tummy ache... she just acts like a kitten! She runs up and down the hallway chasing after her toy, she runs from window to window following this little black and white kitty that hangs around outside, she gives me tons of rubs and purrs and head butts. She's so happy when her tummy doesn't hurt.

        It was awful watching her today, being all pewey all day and not eating, and me begging her to eat. We went outside and she didn't want to even walk in the garden. I hope she will tomorrow.

        Anyway, I think that's everything...her heart, thyroid and pancreas are worse, she has two masses in her liver that may or may not be serious in the near future, kidneys were better (maybe because of the thyroid being up though), but nausea still bad. Hopefully now with the anti-nausea medication, she'll at least feel a little better...I hope.

        Thank you all again for all the help, prayers and good thoughts for Snowball. I appreciate it so much.

        Carol and Snowball and the gang
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