I'm sorry that deuce is having so many problems at the moment. I
should mention that although I have dealth with CRF, hyperT and HCM,
I have not dealt with them in the same cat--there are others here who
have and hopefully will have more information that I can offer on
that. As far as the enalapril/atenolol, I can fill in a little on
those. My Li Li was on both atenolol and benazepril (a similar drug
to enalapril) and did well on both of them.
Atenolol is in a class of drugs called beta-blockers. Beta-blockers
work by blocking the effects of adrenaline on the body's beta
receptors. The nerve impulses that travel through the heart are then
slowed, and the heart does not have to work as hard because the
oxygen requirements will be reduced. Beta-blockers also can help
prevent and treat arrhythmias. Li Li's heart rate went from high
100's to about 120 for most her life. Some cats get a little too
relaxed on beta blockers (it can knock them out) and sometimes the
dose has to be adjusted. Occasionally, a cat cannot tolerate a beta
blocker. Many cats do well on them and the slower heart rate helps
preserve heart function.
Enalapril (and benazepril, and others) are drugs called ACE
inhibitors. ACE inhibitors work by blocking an enzyme in the body
(the angiotensin converting enzyme, or ACE) that causes blood vessels
to narrow. Basically, it opens up the blood vessels. Blood pressure
is often lowered, and it takes some of the workload off of the heart.
Some medications, particularly diuretics, can react with ACE
inhibitors, so the vet usually keeps a very close watch on this
through clinical symptoms and sometimes bloodwork (sometimes
potassium is affected).
It can be safe to use them both together--Li Li did well on them,
however it depends on the individual cat. Your kitty has many other
issues going on and is on other meds. Also, it sounds like there was
a potential blood pressure situation as well.
Have you seen a veterinary cardiologist or internist? They may better
be able to assess the combined effects of everything that is going on.
Linda and Angel Li Li
--- In firstname.lastname@example.org
> Good Morning - My first post on this list with a brief history and
> overview of deuce. Many of you might be familiar with his situation
> from other lists but if you are not he is male domestic shorthair
> will 17 in August. He was diagnosed with CRF in May of 2006, Hyper
> not long after and diagnsed with intestinal lymphoma in August of
> 2006. At that time a low grade murmer 3/6 was found as well. About
> months ago he was found to have mild anemia. Meds are prednisolone
> for the lymphoma - which is currently stable, Tapezole for the
> T, Sub-Q fluids - 150 ml twice a day ; potassium
> supplement,Famotodine for the CRF, NutriVed B-12 /Iron supplemnt
> Epogen for the anemia. He also gets 2ml twice a day of a supplement
> called Rebound and have started FortiFlora a pro-biotic for cats.
> you can see he has a lot of issues. The heart issue follows :
> This past Monday he had three seizures - once at home - once in the
> car on the way to the emergency animal center and once at the
> He was stabilized but it was determined his murmur had increased to
> 5/6 - part of which might have been caused by the stress of being
> the hospital and seizures. Kidney values were very high - can post
> if needed and WBC was very high as well. Clavamox was given in the
> hospital and the high WBC indicated an infection - which can also
> drive up the kidney values. He is still having some weakness in his
> back legs and is unsteady at times. He gets a potassium supplement
> which for some reason was not given while at the emergency center
> that may be a contributing factor there. Direct cause of the
> could not be determined.Upon release he was given Altenelol and
> Enalapril and that is were my questions lie :
> 1 ) Is it ok to give both these at the same time? He was given
> for a brief period at the center and his BP went down. Back to
> when discontinued and was normal upon release on Friday PM.
> 2 ) Has anyone had experiences - positive or negative with these
> 2 ) What are there primary functions and reasons for being