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New HCM research

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  • lorkatz2004
    posted on the CFA list.......Cathy Among the grants funded by the Winn Feline Foundation at its February meeting was the following: Molecular evaluation of the
    Message 1 of 1 , Mar 2, 2007
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      posted on the CFA list.......Cathy


      Among the grants funded by the Winn Feline Foundation at its
      February meeting was the following:
      Molecular evaluation of the feline myosin heavy chain gene in
      Ragdolls, Norwegian Forest cats and Sphynx with familial
      hypertrophic cardiomyopathy
      Kathryn M. Meurs, DVM, PhD, DACVIM; Washington State University;
      $31,550

      Feline hypertrophic cardiomyopathy (HCM) is the most common cause of
      heart disease in the adult cat. Affected cats are at risk of sudden
      death, breathing difficulties or development of a blood clot.
      Increasingly, feline HCM is inherited, with examples noted in the
      Maine Coon, Ragdoll, Norwegian Forest Cat and Sphynx breeds, among
      others. The researcher has demonstrated that HCM is associated with
      a mutation in the myosin binding protein C gene in the Maine Coon
      cat. In human beings, the disease is commonly associated with a
      mutation in one of several genes for heart muscle proteins, most
      commonly the myosin binding protein C and myosin heavy chain genes.
      The research team has collected pedigrees, medical information and
      DNA samples from Ragdolls, Norwegian Forest cats and Sphynx with
      familial HCM. They performed an initial study of affected cats, and
      determined that the Maine Coon mutation is not present in these
      breeds. The researchers now hypothesize that a mutation in the
      myosin heavy chain gene is associated with the development of HCM in
      one or all of these breeds. The objective of this study is to
      evaluate this gene in both affected and unaffected cats for a
      causative mutation.
      [This study was largely funded by the efforts of Ragdoll, Norwegian
      Forest Cat and Sphynx breeders. This study was also supported by the
      Ricky Fund, a fund for the study of feline hypertrophic
      cardiomyopathy established by Steve Dale in memory of his cat,
      Ricky.]
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