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Re: Re: Vit E. question And Vit B

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  • Cynthia Rausch
    gea@alumni.duke.edu wrote: I started giving Malcolm 200 IU per day about a week ago based on the usual recommended dosage for cats (100-400 IU) listed in The
    Message 1 of 1 , Jun 1 7:32 PM
      gea@... wrote:
      I started giving Malcolm 200 IU per day about a week ago based
      on the usual recommended dosage for cats (100-400 IU) listed
      in "The Pill Book Guide to Medication for Your Dog and Cat"
      (Roby & Southam, 1998).

      I did a little reading & found lots of references to Vit. E.'s
      anticoagulant properties but not much (in the clinical literature)
      about its effect on blood presure, but did find the following:

      - a study showing Vit E. decreased blood pressure in rats
      - a study in humans in which Vit. E. showed a trend (but no
      statistically significant difference) in blood pressure in people
      already being treated for hypertension
      - a study in humans showing that Vit. E. intake did correlate with
      decrease in sroke (for only 58 vs. 27 I.U. per day)

      Based upon this last finding, and Cynthia's list, I may decrease
      Malcolm's dose a little, but in his case, a little decrease in blood
      pressure probably wouldn't be a bad thing.

      Gail & Malcolm

      Hi Gail and Malcolm,

      I've been doing some searching too, since this has also come up
      on the Feline IBD list as well, Below are a few articles I found today
      on Vitamin E.

      1: Biol Trace Elem Res 1992 Apr-Jun;33:1-21

      Etiologic factors and pathologic alterations in
      selenium-vitamin E deficiency and excess in animals
      and humans.

      Van Vleet JF, Ferrans VJ.

      Department of Pathobiology, School of Veterinary
      Medicine, Purdue University West Lafayette, IN 47907.

      The etiology of selenium-vitamin E (Se-E) deficiency
      diseases may be complex. Many of the syndromes involve
      combined deficiency of selenium and vitamin E. Selenium
      moves into the animal and human food chain from soil
      and plants, which may contain inadequate amounts of the
      nutrient in many areas of the world. Vitamin E may be in
      low concentration in many animal feeds unless supplements
      are added. Some syndromes, such as steatitis in cats,
      result from an increased requirement of vitamin E in
      diets that contain large amounts of polyunsaturated fatty
      acids, and these diseases will only respond to vitamin
      E administration. Deficiency syndromes in animals owing
      to pure Se deficiency are infrequent and have been
      produced mainly by laboratory studies utilizing extreme
      deficiency conditions. Other factors that may affect
      the occurrence of these deficiency diseases are concurrent
      dietary deficiency of S-containing amino acids,
      bioavailability of different forms of dietary Se, intake
      of compounds that antagonize Se (e.g., silver salts),
      and exposure to various prooxidant substances (e.g.,
      iron compounds, oxygen, ozone, and various drugs).

      PMID: 1379446 [PubMed - indexed for MEDLINE]
      1: Dev Pharmacol Ther 1981;2(3):156-71

      Local and systemic reactions to the parenteral administration
      of vitamin E.

      Phelps DL.

      Significant systemic toxicity has been observed in kittens
      daily with 50-1,000 mg/kg/day parenteral vitamin E for 3
      weeks. The toxicity was dose-related and resulted in
      significant mortality at doses over 100-200 mg/kg daily.
      Local reactions to the injections could be eliminated by
      using the drugs intravenously or intraarterially as
      tested in acute and chronic preparation in the rat, rabbit
      and lamb.

      PMID: 7227141 [PubMed - indexed for MEDLINE]

      And Here is one on Vitamin B I thought everyone would
      be interested in seeing;

      1: J Vet Intern Med 2000 Sep-Oct;14(5):507-12

      Plasma homocysteine, B vitamins, and amino acid
      concentrations in cats with cardiomyopathy and
      arterial thromboembolism.

      McMichael MA, Freeman LM, Selhub J, Rozanski EA,
      Brown DJ, Nadeau MR, Rush JE.

      Department of Clinical Sciences, School of
      Veterinary Medicine, Tufts University, North
      Grafton, MA 01536, USA.

      Arterial thromboembolism (ATE) is a common complication
      of cats with cardiomyopathy(CM), but little is known
      about the pathophysiology of ATE. In people, high plasma
      concentrations of homocysteine and low B vitamin
      concentrations are risk factors for peripheral vascular
      disease. In addition, low plasma arginine concentrations
      have been linked to endothelial dysfunction. The purpose
      of this study was to compare concentrations of homocysteine,
      B vitamins, and amino acids in plasma of normal cats
      to those of cats with CM and ATE. Plasma concentrations of
      homocysteine, vitamin B6, vitamin B12, folate, and amino
      acids were measured in 29 healthy cats, 27 cats with
      CM alone, and 28 cats with both CM and ATE. No differences
      were found between groups in homocysteine or folate. Mean
      vitamin B12 concentration (mean +/- standard deviation)
      was lower in cats with ATE (866 +/- 367 pg/mL) and cats
      with CM (939 +/- 389 pg/mL) compared with healthy controls
      (1,650 +/- 700 pg/mL; P < .001). Mean vitamin B6
      concentration was lower in cats with ATE (3,247 +/- 1.215
      pmol/mL) and cats with CM (3,200 +/- 906 pmol/mL) compared
      with healthy control animals (4,380 +/- 1,302 pmol/mL;
      P = .005). Plasma arginine concentrations were lower in
      cats with ATE (75 +/- 33 nmol/mL) compared with cats with
      CM (106 +/- 25 nmol/mL) and healthy control animals
      (96 +/- 25 nmol/ mL; P < .001). Vitamin B12 concentration
      was significantly correlated with left atrial size. We
      interpret the results of this study to suggest that
      vitamin B12 and arginine may play a role in CM and ATE
      of cats.

      PMID: 11012114 [PubMed - indexed for MEDLINE]


      Cynthia, Taffy, Samuel
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