Re: [FH] Sprite
- Hi Peggy,
My cat (9 lbs) is on Plavix at 1/2 of the dosage of
your cat so on a mg/lb scale, the dose is roughly
identical. I am paying about $5/pill including the
dispensing fee. She seems to be handling the Plavix
well, but she hates the taste. (I wrap it in a soft
treat - about 1/4 of a "Pill Pocket" which she
swallows - if she chews it, she foams a little at the
mouth and spits it out, I originally dissolved it in
tuna water and syringed it - with it all coming back
out as foam!).
As far as dosage, a study was done on in cats with
Plavix (Clopidogrel) at up to the full 75 mg and found
no significant differences in 75 mg, 37.5 or 18.75
mg/per day. But the study was a short-term study not
a long- term study.
It could be that your vet is erring on the side of
caution (higher dose) given that Sprite has already
had clots. You might consider, however, for monetary
reasons, to talk to your vet about cutting the dose
down to 18.75 mg. My vet. cardiologist favors Plavix
over aspirin as she feels it is better tolerated given
that aspirin can be toxic to cats, but aspirin may be
a cheaper alternative. Other people on the board use
PepcidAC or Slippery Elm Bark to help with nausea in
their cats - so perhaps that could help Sprite's
stomach upset following aspirin?
Other people on the board may suggest nattokinase to
my knowledge this enzyme has not been studied
specifically in cats. However, you might rely on the
experience of other members here regarding dosage, how
well their cats tolerate it, and where it can be
I have included a Plavix (clopidogrel) reference for
-Nala, Camille and Cozette.
J Am Vet Med Assoc. 2004 Nov 1;225(9):1406-11. Links
Antiplatelet effects and pharmacodynamics of
clopidogrel in cats.
Hogan DF, Andrews DA, Green HW, Talbott KK, Ward MP,
Department of Veterinary Clinical Sciences, School of
Veterinary Medicine, Purdue University, West
Lafayette, IN 47907, USA.
OBJECTIVE: To evaluate antiplatelet effects and
pharmacodynamics of clopidogrel in cats. DESIGN:
Original study. ANIMALS: 5 purpose-bred domestic cats.
PROCEDURE: Clopidogrel was administered at dosages of
75 mg, p.o., every 24 hours for 10 days; 37.5 mg,
p.o., every 24 hours for 10 days; and 18.75 mg, p.o.,
every 24 hours for 7 days. In all cats, treatments
were administered in this order, with at least 2 weeks
between treatments. Platelet aggregation in response
to ADP and collagen and oral mucosal bleeding times
(OMBTs) were measured before and 3, 7, and 10 days (75
and 37.5 mg) or 7 days (18.75 mg) after initiation of
drug administration. Serotonin concentration in plasma
following stimulation of platelets with ADP or
collagen was measured before and on the last day of
drug administration. Platelet aggregation, OMBT, and
serotonin concentration were evaluated at various
times after drug administration was discontinued to
determine when drug effects were lost. RESULTS: For
all 3 dosages, platelet aggregation in response to ADP
platelet aggregation in response to collagen, and
serotonin concentration were significantly reduced and
OMBT was significantly increased at all measurement
times during drug administration periods. All values
returned to baseline values by 7 days after drug
administration was discontinued. No significant
differences were identified between doses. None of the
cats developed adverse effects associated with drug
administration. CONCLUSIONS AND CLINICAL RELEVANCE:
Results suggest that administration of clopidogrel at
dosages ranging from 18.75 to 75 mg, p.o., every 24
hours, results in significant antiplatelet effects in
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Welcome back to the group. Sorry to hear that Sprite has problems. I can't
answer your medical questions but I can comment on a couple things.
As for dosage - I don't know specifically about Plavix but for comparison,
my cat gets 60mg lasix daily compared to my friend who gets 5mg. Cats &
people aren't always comparable.
A lot of people on the Feline Asthma & Bronchitis group buy medications from
Canada. Often the prices are less. There are complications due to laws
governing cross-border sales of prescription drugs. I did hear that they
just lifted the ban, but then there's still the issue of the Canadian postal
system. Someone on this group mailed me something from Canada on 7/15 and
it still hasn't arrived.
While the restriction was on, you could order from Canada, but the product
was often shipped from elsewhere. One person talked about getting a
prescription filled in a Canadian pharmacy that was shipped from New
Anyway, here are some Canadian pharmacies that people have personally
recommended. (I have not had the need to purchase medications from them
since Pepper uses the same medication I do for asthma and my prescription
plan is very good.)
(West Vancouver, British Columbia)
Tel (800) 794-8552
FAX (866) 889-5010
Tel (888) 423-9444
FAX (888) 423-7860
(Universal Drugstore, Winnipeg, Manitoba)
Tel (866) 456-2456
FAX (866) 783-4223
(Calgary, Alberta, formerly halfoffmeds.com)
Tel (866) 585-6337
FAX (866) 872-2299
My Pepper was over 18 pounds when she was first diagnosed. By getting her
off of dry food and switching to a good-quality canned food, she lost 2-1/2
pounds. I did not restrict the amount of food she was eating. Grains -
especially corn & wheat - contribute to weight gain and various medical
problems. Do a search in the message archives for "OldMotherHubbard" and
you will find a list of recommended foods.
----- Original Message -----
From: "Peggy G" <peggyg1@...>
Sent: Tuesday, August 01, 2006 2:25 PM
Subject: [FH] Sprite
Hi - Since I lost my dear little Phantom I have been on the no mail
option. Now Sprite has a heart problem and I'd like some advice.
Sprite is a neutered 12 year old. He apparently had a thrombosis
earlier and as a result has an enlarged heart.
Can anyone give me some insight on their experience with dosages?
The Plavix especially concerns me - isn't that a little high for a
cat? He weighs almost 20 lbs but compared to the dosage a human
would get that still seems high. What about the side affects of slow
clotting - could the Plavix cause internal bleeding? I try to give
him all his meds with food.
Also Plavix is expensive, $5.50 a tab - has anyone explored getting
meds from Canada?
I would like to have Sprite lose weight but I have done a lot of
rescue work and currently have 19 cats - there is no way I can feed
other then free access. I try to make sure that they have good
quality food and I've started getting the lower calorie food.
Welcome back to you and welcome to Sprite. I am sorry to hear of his diagnosis. Having been through this before, I am sure it was hard for you to find this out.
I don't have any experience with Plavix but I am glad to hear your cardiologist is prescribing it. Many do not. I do have experience with the Nattokinasse. My Angel Alec used it for his RCM because he was at a greater risk for clots with the RCM. He never got a clot while he was on it and he had a terrible heart. I recommend it. I gave one 50mg pill a day. I paid about $35 for 60 pills. A little expensive but Alec was worth it. I would probably give this in addition to the Plavix. Ask your cardio if they have any problems with it, if you want. It is a very small pill too for pilling or hiding in a treat.
I hope this helps! Bless your heart for helping so many kitties too!
Leah and her cats and Angel Alec
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