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Sprite

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  • Peggy G
    Hi – Since I lost my dear little Phantom I have been on the no mail option. Now Sprite has a heart problem and I d like some advice. Sprite is a neutered 12
    Message 1 of 4 , Aug 1, 2006
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      Hi – Since I lost my dear little Phantom I have been on the no mail
      option. Now Sprite has a heart problem and I'd like some advice.
      Sprite is a neutered 12 year old. He apparently had a thrombosis
      earlier and as a result has an enlarged heart.

      I learned there was a cardiac specialist in the area and took
      Sprite. Sprite has been on 1/2 a tab of Furosemide (6.25mg) once a
      day and 2.5 mg of Enalapril twice a day since April. He also was on
      1/2 a baby aspirin 2x/week but it upset his stomach. He really
      picked up under the specialists recommended dosage.

      Early Friday morning I noticed Sprite was dragging one leg, so I
      assumed that he had thrown another clot and had stroke. I put him on
      the bed so I could watch him, he rapidly developed labored breathing
      so I called my vet and sped him over there (it was 4:30 AM I was so
      grateful that my vet was available). Sprite survived the weekend and
      is home now. I called the specialist and requested something
      additional medication that could help prevent clotting Sprite is now
      also on 1/2 a 75 mg tab of Plavix once a day.

      Can anyone give me some insight on their experience with dosages?
      The Plavix especially concerns me – isn't that a little high for a
      cat? He weighs almost 20 lbs but compared to the dosage a human
      would get that still seems high. What about the side affects of slow
      clotting – could the Plavix cause internal bleeding? I try to give
      him all his meds with food.

      Also Plavix is expensive, $5.50 a tab – has anyone explored getting
      meds from Canada?

      I would like to have Sprite lose weight but I have done a lot of
      rescue work and currently have 19 cats – there is no way I can feed
      other then free access. I try to make sure that they have good
      quality food and I've started getting the lower calorie food.

      Peg
    • nala nala
      Hi Peggy, My cat (9 lbs) is on Plavix at 1/2 of the dosage of your cat so on a mg/lb scale, the dose is roughly identical. I am paying about $5/pill including
      Message 2 of 4 , Aug 1, 2006
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        Hi Peggy,

        My cat (9 lbs) is on Plavix at 1/2 of the dosage of
        your cat so on a mg/lb scale, the dose is roughly
        identical. I am paying about $5/pill including the
        dispensing fee. She seems to be handling the Plavix
        well, but she hates the taste. (I wrap it in a soft
        treat - about 1/4 of a "Pill Pocket" which she
        swallows - if she chews it, she foams a little at the
        mouth and spits it out, I originally dissolved it in
        tuna water and syringed it - with it all coming back
        out as foam!).

        As far as dosage, a study was done on in cats with
        Plavix (Clopidogrel) at up to the full 75 mg and found
        no significant differences in 75 mg, 37.5 or 18.75
        mg/per day. But the study was a short-term study not
        a long- term study.

        It could be that your vet is erring on the side of
        caution (higher dose) given that Sprite has already
        had clots. You might consider, however, for monetary
        reasons, to talk to your vet about cutting the dose
        down to 18.75 mg. My vet. cardiologist favors Plavix
        over aspirin as she feels it is better tolerated given
        that aspirin can be toxic to cats, but aspirin may be
        a cheaper alternative. Other people on the board use
        PepcidAC or Slippery Elm Bark to help with nausea in
        their cats - so perhaps that could help Sprite's
        stomach upset following aspirin?

        Other people on the board may suggest nattokinase to
        you. To
        my knowledge this enzyme has not been studied
        specifically in cats. However, you might rely on the
        experience of other members here regarding dosage, how
        well their cats tolerate it, and where it can be
        purchased etc.

        I have included a Plavix (clopidogrel) reference for
        you below,

        -Nala, Camille and Cozette.

        J Am Vet Med Assoc. 2004 Nov 1;225(9):1406-11. Links
        Antiplatelet effects and pharmacodynamics of
        clopidogrel in cats.

        Hogan DF, Andrews DA, Green HW, Talbott KK, Ward MP,
        Calloway BM.

        Department of Veterinary Clinical Sciences, School of
        Veterinary Medicine, Purdue University, West
        Lafayette, IN 47907, USA.

        OBJECTIVE: To evaluate antiplatelet effects and
        pharmacodynamics of clopidogrel in cats. DESIGN:
        Original study. ANIMALS: 5 purpose-bred domestic cats.
        PROCEDURE: Clopidogrel was administered at dosages of
        75 mg, p.o., every 24 hours for 10 days; 37.5 mg,
        p.o., every 24 hours for 10 days; and 18.75 mg, p.o.,
        every 24 hours for 7 days. In all cats, treatments
        were administered in this order, with at least 2 weeks
        between treatments. Platelet aggregation in response
        to ADP and collagen and oral mucosal bleeding times
        (OMBTs) were measured before and 3, 7, and 10 days (75
        and 37.5 mg) or 7 days (18.75 mg) after initiation of
        drug administration. Serotonin concentration in plasma
        following stimulation of platelets with ADP or
        collagen was measured before and on the last day of
        drug administration. Platelet aggregation, OMBT, and
        serotonin concentration were evaluated at various
        times after drug administration was discontinued to
        determine when drug effects were lost. RESULTS: For
        all 3 dosages, platelet aggregation in response to ADP
        platelet aggregation in response to collagen, and
        serotonin concentration were significantly reduced and
        OMBT was significantly increased at all measurement
        times during drug administration periods. All values
        returned to baseline values by 7 days after drug
        administration was discontinued. No significant
        differences were identified between doses. None of the
        cats developed adverse effects associated with drug
        administration. CONCLUSIONS AND CLINICAL RELEVANCE:
        Results suggest that administration of clopidogrel at
        dosages ranging from 18.75 to 75 mg, p.o., every 24
        hours, results in significant antiplatelet effects in
        cats.





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      • Sue at MAGDRL
        Peggy, Welcome back to the group. Sorry to hear that Sprite has problems. I can t answer your medical questions but I can comment on a couple things. As for
        Message 3 of 4 , Aug 1, 2006
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          Peggy,

          Welcome back to the group. Sorry to hear that Sprite has problems. I can't
          answer your medical questions but I can comment on a couple things.

          As for dosage - I don't know specifically about Plavix but for comparison,
          my cat gets 60mg lasix daily compared to my friend who gets 5mg. Cats &
          people aren't always comparable.

          A lot of people on the Feline Asthma & Bronchitis group buy medications from
          Canada. Often the prices are less. There are complications due to laws
          governing cross-border sales of prescription drugs. I did hear that they
          just lifted the ban, but then there's still the issue of the Canadian postal
          system. Someone on this group mailed me something from Canada on 7/15 and
          it still hasn't arrived.

          While the restriction was on, you could order from Canada, but the product
          was often shipped from elsewhere. One person talked about getting a
          prescription filled in a Canadian pharmacy that was shipped from New
          Zealand.

          Anyway, here are some Canadian pharmacies that people have personally
          recommended. (I have not had the need to purchase medications from them
          since Pepper uses the same medication I do for asthma and my prescription
          plan is very good.)

          www.mapleleafmeds.com

          (West Vancouver, British Columbia)
          Tel (800) 794-8552

          FAX (866) 889-5010

          www.petpharm.org

          (Toronto, Ontario)
          Tel (888) 423-9444

          FAX (888) 423-7860

          www.rx-canada.com

          (Universal Drugstore, Winnipeg, Manitoba)
          Tel (866) 456-2456

          FAX (866) 783-4223

          www.smartchoicepharmacy.com

          (Calgary, Alberta, formerly halfoffmeds.com)
          Tel (866) 585-6337

          FAX (866) 872-2299

          www.thecandiandrugstore.com

          www.tcds.com

          (Toronto, Ontario)
          Tel (888)372-2252

          Fax (888)575-5506



          My Pepper was over 18 pounds when she was first diagnosed. By getting her
          off of dry food and switching to a good-quality canned food, she lost 2-1/2
          pounds. I did not restrict the amount of food she was eating. Grains -
          especially corn & wheat - contribute to weight gain and various medical
          problems. Do a search in the message archives for "OldMotherHubbard" and
          you will find a list of recommended foods.



          Sue


          ----- Original Message -----
          From: "Peggy G" <peggyg1@...>
          To: <feline-heart@yahoogroups.com>
          Sent: Tuesday, August 01, 2006 2:25 PM
          Subject: [FH] Sprite


          Hi - Since I lost my dear little Phantom I have been on the no mail
          option. Now Sprite has a heart problem and I'd like some advice.
          Sprite is a neutered 12 year old. He apparently had a thrombosis
          earlier and as a result has an enlarged heart.

          Can anyone give me some insight on their experience with dosages?
          The Plavix especially concerns me - isn't that a little high for a
          cat? He weighs almost 20 lbs but compared to the dosage a human
          would get that still seems high. What about the side affects of slow
          clotting - could the Plavix cause internal bleeding? I try to give
          him all his meds with food.

          Also Plavix is expensive, $5.50 a tab - has anyone explored getting
          meds from Canada?

          I would like to have Sprite lose weight but I have done a lot of
          rescue work and currently have 19 cats - there is no way I can feed
          other then free access. I try to make sure that they have good
          quality food and I've started getting the lower calorie food.

          Peg
        • Leah Ferron
          Peg, Welcome back to you and welcome to Sprite. I am sorry to hear of his diagnosis. Having been through this before, I am sure it was hard for you to find
          Message 4 of 4 , Aug 1, 2006
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            Peg,

            Welcome back to you and welcome to Sprite. I am sorry to hear of his diagnosis. Having been through this before, I am sure it was hard for you to find this out.

            I don't have any experience with Plavix but I am glad to hear your cardiologist is prescribing it. Many do not. I do have experience with the Nattokinasse. My Angel Alec used it for his RCM because he was at a greater risk for clots with the RCM. He never got a clot while he was on it and he had a terrible heart. I recommend it. I gave one 50mg pill a day. I paid about $35 for 60 pills. A little expensive but Alec was worth it. I would probably give this in addition to the Plavix. Ask your cardio if they have any problems with it, if you want. It is a very small pill too for pilling or hiding in a treat.

            I hope this helps! Bless your heart for helping so many kitties too!

            Leah and her cats and Angel Alec



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