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Re: [FH] Diabetes/anemia/heart failure/kidney failure: Please help!

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  • Susan
    ... Mike and Lisa, I am sorry to hear about Soda. When Soda was released he was stable but the problem that caused him to have RCM is not something that is
    Message 1 of 3 , Aug 3, 2004
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      --- tiger6387 <tiger6387@...> wrote:

      > The specialist ran a battery of tests, took Xrays
      > and ultrasound. She
      > diagnosed a new problem: "Restrictive Cardiomyopathy
      > and Congestive Heart Failure> problems controlled
      > and released him to us. But he is MUCH MUCH WORSE
      > than he was before
      > we took him to these people! He can no longer walk;
      > his muscles are
      > weak, and when he tries to stand he loses his
      > balance. He is not
      > eating. He is unbelievably thirsty. He vomits.

      Mike and Lisa,

      I am sorry to hear about Soda. When Soda was released
      he was stable but the problem that caused him to have
      RCM is not something that is cured, rather it is
      something that we attempt to modulate via various
      medicines. There are many links in the links section
      specifically about CHF that are very good. It is
      important that Soda eats because of the med he is on
      that enables him to breathe. Ask your vet for a couple
      cans of Hills A/D a critical care prescription food.
      You can either finger or syringe feed it to him.


      RCM is not as common as HCM but a few members have
      dealt with it. Look for posts about a cat named Morag.

      Here is a link to get you started:

      Advances in Treatment of Heart Failure

      Soda's weight fell because an animal in a critical
      care situation catabolizes lean muscle mass. This is
      called cachexia.

      Nutritional Therapy of Heart Disease

      > This is the specialist's prescriptive regimin:
      > 1. 100cc plasmalyte A twice a day
      > (Before, we were giving him 150cc Ringers once a
      > day)
      > 2. Hill's K/D food
      > (Before, we were giving him Hill's W/D)

      The most serious issue Soda is facing is his heart.
      Hill's A/D is ideal for a cat who is not eating enough
      to maintain his lean muscle mass.
      > 3. 3 units PZI insulin once a day
      > (Before, we were giving him 2 units humulin twice a
      > day)
      > 4. Enalapril 1mg tablet twice a day

      This is an ACE-inhibitor
      > 5. Furosemide 12.5mg, 1/2 tablet twice a day

      This is the diuretic that enables Soda's breathing
      > 6. Famotidine, 1/4 tablet every 12-24 hours
      > We are taking Soda to his regular vet in the
      > morning. Please--we will
      > listen to any advice! Thank you so much. --Mike
      > and Lesa
      > Here are some test results for Soda from the
      > specialist taken on
      > Friday when we broght him there:
      > BUN 107
      > Creatine 2.6
      > Phosphorus 7.1
      > Glucose 684
      > Potassium 4.8
      > Osmolality, calculated 372
      > Magnesium 2.6
      > WBC 8.3
      > RBC 3.4
      > HGB 5.6
      > HCT 15
      > Lymphosytes 996
      > Monocytes 913
      > T4 (RIA) .26
      > BPc (blood pressure?) 154-164 over 4 days
      > While in the care of the "specialists," Soda's
      > weight fell from 9.4 to
      > 8.2 pounds.
      > Thank you again for any help or suggestions. All
      > the best from Lesa,
      > me, our cats Soda, Sammy, and Tiger, to you and your
      > family and pets!
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    • savionna@aol.com
      Hi Lesa, In a message dated 8/3/04 3:52:52 AM, tiger6387@yahoo.com writes:
      Message 2 of 3 , Aug 4, 2004
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        Hi Lesa,

        In a message dated 8/3/04 3:52:52 AM, tiger6387@... writes:

        << But in the past two weeks his appetite had diminished and he was losing

        weight. >>

        A leading contributing factor to weight loss in diabetics is poor glucose
        control. The cells can't use the "fuel" from food without the "right" amt of
        insulin. And while uncontrolled diabetics are usually ravenously hungry, they can
        also be inappetant. Renal issues will also affect appetite.

        << Also, his blood glucose was not being controlled by his

        insulin, but we found that if we bumped the dose up (from 2 units

        Humilin to 3 units, twice a day) >>

        Which Humulin? Ultralente? Lente? N? "Humulin" is the *brand name* of
        genetically engineered insulin from Eli Lilly. U, L, and N are diff. *formulations*
        of insulin with very diff. activity profiles (onset, peak, and duration). For
        info on this, see:

        1. www.petdiabetes.org/insulin.html

        2. www.lillydiabetes.com/Products/TimeActivityProfiles.cfm

        << that Soda would have a seizure. >>

        That "seizure" is more than an indicator of lack of control...it signals the
        potential for significant neurological damage and death when too much insulin
        is given. Did the vets instruct how to care for the cat in a hypoglycemic
        episode? If not, some info is here:

        Did the vets mention that it's possible to test the cat's blood at home using
        a portable monitor just like humans rely on? Hometesting is an easy,
        inexpensive, reliable way to effectively manage blood sugar...to achieve good control
        and avoid the significant dangers of hypoglycemia. Some sites on this incl:

        1. www.petdiabetes.org/home_bg_testing.htm
        2. www.sugarcats.net/sites/harry/bgtest.htm
        3. http://tlb.best.vwh.net/bg_punkin/test_bg.html

        << 2-3 famotidine injections daily >>

        Famotodine (Pepcid Rx) is simply an acid blocker for the stomach that can
        help with nausea.

        << 2-3 metocloropramide injections >>

        Metoclopramide (Reglan Rx) is used to reduce gastric uspet and improve
        gastric outflow (diabetics can have gastroparesis, from nerve damage to the
        digestive system).

        << two glucose curves >>

        What did the curves indicate?

        << But he is MUCH MUCH WORSE than he was before

        we took him to these people! >>

        Part of the reason *may* be that they changed the insulin formulation...and
        it's going to take a while for the cat's body to adjust.

        << He can no longer walk >>

        There can be various contributing factors to this. A possible one is diabetic
        neuropathy, which is related to the same type of nerve damage that affects
        the digestive system. It is caused by excess glucose, which damages the nerve
        sheaths. For some information, see www.laurieulrich.com/jasper.

        << 2. Hill's K/D food

        (Before, we were giving him Hill's W/D) >>

        It may be worthwhile considering the role of diet in diabetes. Hill's w/d is
        high in carbohydrate (38% calories from carbs in the dry; 23% in canned),
        which is exactly the *opposite* of what any cat needs, more so a diabetic, who has
        no ability to control glucose naturally. Cats are *obligate carnivores* who
        have *no* dietary requirement for carbohydrate and limited ability to process
        it. A possible result of feeding an obligate carnivore a high-carbohdyrate diet
        is *diabetes*. The recommended diet for nearly all cats, but esp diabetics,
        is a high-quality, low-carbohydrate (at least less than 10% cal from carb),
        well-balanced, moisture-rich, meat-based diet.

        K/d is low in protein, which is now thought to be the inappropriate approach
        for animals with renal issues. The recommended diet is the highest amt of
        high-quality protein that the individual cat can tolerate with the lowest amt of
        *phosphorus*. K/s is also high in carbohydrate (35% cal from carbs in the dry;
        28% in canned).

        Further, both of these products are poor in the type of high-quality
        nutrients that cats need to survive.

        That said, it is important for the cat to eat, esp when receiving insulin (to
        avoid not only malnutrition but also hypoglycemia and liver
        complications)...so whatever food is palatable and acceptable can be offered. It is also
        important to keep in mind that the amt and type of food will affect insulin
        response. In general, the lower the carbohdyrate level, the less the amt of insulin

        For information on diet and diabetes...and general info on feline nutrition,

        1. http://rocquoone.com/diet_and_health.htm
        2. www.avma.org/convention/recap/news/tuesday16.asp
        3. http://home.earthlink.net/~jacm2/id1.html
        4. www.catinfo.org
        5. www.homevet.com/petcare/feedingyourcat.html
        6. www.maxshouse.com/feline_nutrition.htm

        For info on diet and renal issues, see:

        1. www.southpaws.com/news/99-2-nutrition-CF.htm
        2. www.vetshow.com/download/purina/finco.pdf
        3. www.vetshow.com/download/purina/bovee.pdf
        4. www.cm-d.com/buckeye/tech_manual/8_28.html
        5. www.bowchow.com/kidney.html

        For general info on renal issues in cats, see:

        1. www.felinecrf.com
        2. www.felinecrf.org
        3. www.mindspring.com/~kerspin

        For charts with nutrient information (incl carbohydrate and phosphorus) of
        common cat foods, see:

        1. www.sugarcats.net/sites/jmpeerson
        2. webpages.charter.net/katkarma

        << 3 units PZI insulin once a day >>

        The *starting dose* was 3 units of PZI SID...after 4 days of hospitalization?
        The recommended safe starting dose of all insulins is 1 unit BID, except for
        those in danger from ketoacidosis or other life-threatening complications. The
        protocol for raising the dose thereafter is to let each dose "settle" (which
        generally takes at least 7-10 days), perform a full curve (12 hrs), then
        adjust as needed by no more than 0.5 units. Almost no cats get 24 hr duration from
        any insulin, even the long-duration types like PZI, which makes it all the
        more important to perform curves to see the full effect before adjustment.

        << BUN 107 >>

        Since you didn't give the ref range, I'll go by the Antech range. For BUN,
        it's 14-36, so this is high. BUN can be elevated for various reasons besides
        renal issues (acute or chronic), such as dehydration, infection, and poor glucose

        << Creatine 2.6 >>

        This is slightly elevated (ref 0.6-2.4)...and can also indicate dehydration
        and poor glucose control.

        << Phosphorus 7.1 >>

        While this is in range (2.4-8.2), it's desirable for the phos to be around 4.
        Did the vet discuss the possibility of using a phos binder?

        << Glucose 684 >>

        This is quite elevated (ref is 50-150 mg/dL and the desirable range for cats
        on insulin is 100-300 mg/dL) However, glucose values are meaningful only in
        relation to each other and to the insulin cycle.

        << Potassium 4.8 >>

        Ref is 3.4-5.6, so this is not too bad.

        << RBC 3.4

        HGB 5.6

        HCT 15 >>

        These are quite low.

        << T4 (RIA) .26 >>

        This is a thyroid indicator. Did you mean 2.6 (micro)g/dL...or is it a diff.

        Did the vets perform a urinalysis? If not, you may want to bring a clean
        sample or have a cystocentesis. It would be important to see the urine specific
        gravity for information on renal status...and also to check for infection, since
        diabetics are prone to urinary (and other) infections, incl in the kidneys.
        Indicators to look for incl bacteria, WBC, RBC, and blood. // Rosemary
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