ACE Inhibitors for Tabby Jean?
- Here's the update, fellow fur luvers!
TJ, as you know, was diagnosed with some form of cardiomyopathy about 3 months ago.
She has an enlarged left ventricle, a gallop rhythm, irregular EKG with premature
ventricular contractions. Has moderate lesions on her aortic valve that is causing
moderate blood flow reguritation. Is asymptomatic-runs around like a maniac with her
sister, Tazzleberry Marie.
Atenolol and another beta-blocker have not worked.
Doctor B is discussing ACE Inhibitors; I showed her Susan's post on the subject. Tabby is
stable; her recent sonogram is identical to the first one from 3 months ago.
I don't know if the ACE Inhibitors are worth the risk of damage to TJ's kidneys. Doctor B
things the entire problem is the result of an old an inactive infection: endocarditis. That
explains the valve lesions, the blood backflow, and the resultant strain is what probably
caused the ventricle to enlarge.
I'm thinking at this point taking her for holistic treatment(Dr. B. has recommended a
holistic vet) instead of the ACE inhibitors.
Your thoughts? Suggestions? TJ says the WHOLE thing is best addressed by giving her a
constant supply of salmon treats, live mice from the Pet Store, and plenty of catnip toys,
round the clock, 24-7. Plus tossing her little sister, Taz, into the trash chute(they've got a
SERIOUS love/hate thing going).
I think she's off base.
I'd appreciate any feedback here.
TJ and Taz's Dad, Paul R.
- --- sandworm90292 <erosla77@...> wrote:
> Here's the update, fellow fur luvers!By not worked do you mean that beta-blockade has not
> TJ, as you know, was diagnosed with some form of
> cardiomyopathy about 3 months ago.
> She has an enlarged left ventricle, a gallop
> rhythm, irregular EKG with premature
> ventricular contractions. Has moderate lesions on
> her aortic valve that is causing
> moderate blood flow reguritation. Is
> asymptomatic-runs around like a maniac with her
> sister, Tazzleberry Marie.
> Atenolol and another beta-blocker have not worked.
slowed her heart rate or have not addressed the PVCs?
from VetGo cardiology concepts:
Consequences of PVCs:
Several isolated premature beats are of no hemodynamic
However, when enough of these beats are present, a
marked reduction in cardiac output may result (due to
a loss of atrial induced ventricular filling and high
Several isolated beats do not warrant therapy.
However, such individuals should be frequently
monitored for exacerbation of their rhythm
disturbance. In addition, attention should be directed
toward identification and management of the underlying
Criteria for therapy include:
if the animal is symptomatic with this disorder
if paroxysms of sustained tachycardia develop such as
a burst lasting greater than 60 sec.
Drugs commonly used include:
beta blocker therapy: propranolol metoprolol
calcium channel blocker therapy: diltiazem
cat: 1/4 of 0.125 mg (PO) q 48h - SID
cat: 0.21-1.0 mg/kg BID-TID (PO); 0.04 mg/kg (IV)
cat: 2-15 mg TID (PO)
cat: 5-12.5 mg SID (PO)
cardizem: 1-2 mg/kg TID (PO)
cardizem CD: 10 mg/kg SID (PO)
Comment: Although propranolol is the best known beta
blocker in veterinary medicine, it has drawbacks in
its combined beta 1 and beta 2 blocking activity. We
should attempt to use beta-1 selective beta blocker
such as metoprolol and atenolol. As well the Ca
channel blockers, such as diltiazem, may be
particularly useful in these disorders.
>I cannot remember if Tabby Jean is on lasix. The vast
> Doctor B is discussing ACE Inhibitors; I showed
> her Susan's post on the subject. Tabby is
> stable; her recent sonogram is identical to the
> first one from 3 months ago.
majority of cats on Lasix are also on an ACE-I because
the activation of the renin angiotensin system has the
effect of causing further remodeling of the left
ventricle. If TJ is not on lasix then she is not
considered to be in CHF and certainly no treatment is
an option. Was a calcium channel blocker tried and was
a CCB plus BB tried? I know I have seen references to
that combo for refractory tachycardia (fast heart
>Is TJ CRF and how old is she?
> I don't know if the ACE Inhibitors are worth the
> risk of damage to TJ's kidneys.
Rudy: Male DSH brown tabby, feral mom, diagnosed 09-2002 at 19 months of age with idiopathic HCM: grade 2 murmur, hyperkinetic heart, borderline normal thickening, considered asymptomatic, 12.5 mg Atenolol 1x day, 1/2 baby aspirin 2x week administered via pilling
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