Re: [feline-heart] crf and high blood pressure
- Thanks for the article! We've had excellent results with Norvasc (along with
Diltiazem) in our two HCM/CRF/hypertension kitties. Lower blood pressure has
meant better kidney values.
Laura, Lucky & Kassy
From: Agnes Moscrip <anyes@...>
To: crflist crflist <feline-crf@...>;
Date: Wednesday, January 03, 2001 12:05 AM
Subject: [feline-heart] crf and high blood pressure
>The following site has an excellent discussion on the importance ofedscape.htm
>controlling high blood pressure and its effect on the kidneys.
>Increased blood flow to the kidneys improve kidneys condition and this
>was my personal observation after getting treatment for my crf/hcm/hbp
>kitty. The text is geared to humans and modified by Dr. Newman DVM...
>It also has an excellent discussion on kidney disease, its causes and
>I hope that helps,
>Anyes, angel Lucie, Georgina and Angelica
>...''Control of systemic hypertension. Systemic hypertension is an
>important mediator of progressive renal injury; there is unequivocal
>evidence that lowering elevated BP slows the progression of renal
>disease, especially in patients with proteinuria. A subgroup analysis
>of MDRD study data showed that, in patients with urinary protein
>excretion >1 g/day, the rate of decline in renal function was slowest
>in those whose BP was maintained at 125/75 mm Hg. In patients
> without proteinuria there appeared to be little additional renal
>benefit to maintaining BP below 135/85 mm Hg...."
>..."In sum, ACE inhibitors slow the progression of renal failure in
>patients with a wide variety of renal diseases and should be started
>early in the course. Patients with proteinuria are likely to derive the
>greatest benefit. The risk of adverse reactions is small but warrants
>close monitoring after the start of therapy. The specific agent used is
>not important, provided ppropriate dosage adjustments for renal
>dysfunction are made when necessary.
>Use of calcium channel blockers. Although not as well studied as the
>ACE inhibitors, CCBs may also have renoprotective properties. The
>mechanism of this protective effect may differ between the
>dihydropyr-idines (eg, amlodipine, nifedipine, felodipine) and other
>CCBs such as verapamil or diltiazem. The latter two drugs may reduce
>intraglo-merular pressure in a manner similar to that of ACE
>inhibitors; studies in patients with renal disease have shown that
>these drugs, as compared with the ß blocker atenolol, led to a greater
>reduction in proteinuria and a slower progression of renal disease. One
>study has demonstrated an additive reduction in proteinuria when a
>low-dose ACE inhibitor and verapamil were combined."...
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- Can anyone help with advice on the correct dose of the ACE inhibitor
Benazepril (Fortekor) for Dusty, our 3kg CRF cat. She's been put on
half a 5mg tablet a day following systolic BP of 165-170, measured
using a Doppler on her front leg, plus heart murmur.
Anything I've found says 0.25 - 0.5 mg/kg, which makes a third of a
tablet - but is there a minimum ?
I can't find any literature as Benazepril was only licenced for CRF
cats in the UK this month