35706Re: [FH] IMPORTANT INFO: Taking CoQ10 with blood thinners
- Feb 2, 2009Sangie has been taking CoQ10 for many years. She started heperin
treatment in Sept 2008 & I had no idea of the possible adverse affects
it might have. I guess I'll start weaning her off the CoQ.
Thanks so much for this post.
> My mom was just diagnosed with Atrial Fibrilation, her upper chamber--
> of her heart is enlarged and she has an irregular heart beat. She
> was prescribed Warfarin (Coumadin) blood thinner to prevent clotting.
> On the info from the drug handout, it says to NOT take CoQ10 with
> blood thinners, because it interferes with the anti-clotting action
> of the Warfarin/Coumadin.
> Well, I did some checking, because I couldn't believe that this was
> true. I've been giving my heart kitties blood thinners (either drugs
> or nattokinase) for years and also giving them CoQ10. I was shocked
> at what I found today, and I think everyone needs to know about
> this, so they can do their own research and make their own
> decisions. I'm still trying to find out more too.
> CoQ10 supposedly is structurally related to Vitamin K, which
> enhances clotting in the blood, so if you're taking a blood thinner,
> you DO NOT want to take Vitamin K. Well, if CoQ10 has clotting
> properties, then we should not be giving it to our kitties either!
> Right?! I'm very confused and upset about my findings today.
> Here's one site that I found with info, and there are tons more. I
> did a Google search for "interactions with coumadin and CoQ10".
> That's how I found these. Now what I found is related to
> specifically Warfarin/coumadin, but it applies to all blood
> thinners, including nattokinase.
> Coenzyme Q10 is structurally related to vitamin K and subsequently
> possesses procoagulant effects. The potentially critical interaction
> can result as a diminished response to warfarin therapy. Several
> case reports describe decreases in international normalized ratio
> (INR) after the addition of CoQ10 in patients previously stabilized
> with warfarin therapy.[59, 60] With discontinuation of CoQ10,
> responsiveness to warfarin therapy resumed and INR values returned
> to levels seen prior to provitamin supplementation.[59, 60] The
> concomitant use of warfarin and CoQ10 should be avoided due to the
> risk of thrombotic complications.
> Coenzyme Q10 (also known as ubiquinone or ubidecarenone) is used for
> congestive heart failure and other cardiovascular disorders. It
> can reduce the anticoagulant effect of warfarin. There have been two
> case reports describing decreased International Normalized Ratios
> (INRs) when coenzyme Q10 was added to warfarin therapy on which
> patients had been stable.[21,22]
> In animals, coenzyme Q10 antagonizes the anticoagulant effects of
> warfarin. Coenzyme Q10 is structurally related to men-aquinone
> (vitamin K2), suggesting a pharmacodynamic interaction with warfarin.
> Here are some sites with info about herb/supplement interactions
> with blood thinners (specifically Warfarin/coumadin).
> org=commodore&ContentID=1539003 or http://tinyurl.com/cr4ehq
> This site states that if you're already taking CoQ10 supplementation
> to "not" stop it when you start taking blood thinners (coumadin).
> http://tinyurl.com/caj8kv <http://tinyurl.com/caj8kv>
> Coenzyme Q10 (ubidecarenone) resembles vitamin K (chemically) and
> may also reduce the effectiveness of warfarin.10 If a patient is
> already taking Coenzyme Q10, then discontinuing supplementation of
> CoQ is not recommended before initiating warfarin therapy. However,
> it is advisable not to initiate CoQ supplementation in a patient
> starting warfarin dosing.
> There are also other herbs that interfere with blood thinners,
> including chamomile and ginko biloba. Of course there's the usual
> food things like onions and garlic that thin the blood, which we
> don't give our kitties, because of them causing Heinz Bodies Anemia,
> so those we don't worry too much about, but I also found out that
> Ginger also thins the blood and can increase the risk of internal
> bleeding if taking blood thinners. This is very upsetting to me,
> because we use ginger all the time for my mom for digestion and
> stomach upset.
> I've been interested in and studying holistic and alternative
> treatments for several years, since the early 1980's, and I've never
> come across this info about CoQ10 and blood thinners. Now that I
> have, I'm concerned about how to treat Snowball's heart issues, and
> worried about all of our kitties on this group who have to take
> blood thinners and are taking CoQ10.
> Can someone on the group who is very knowledgable about the
> CoQ10/blood thinners interactions please chime in here and give us
> some more information? This is a very serious thing I found out
> today, and had my mom not just been diagnosed with her heart
> problems, I'd have never known this about CoQ10 (it having clotting
> Now, I don't want to panic anyone and have you all stop your CoQ10
> that you're giving your kitties. You CAN NOT just stop CoQ10 cold
> turkey. You have to slowly wean off of it. Stopping it cold can
> result in negative affects on the heart. The heart muscle gets used
> to a certain inflow of CoQ10, helping it function properly (CoQ10
> helps strengthen the heart muscles), and if you take that away
> suddenly, you have the risk of the heart going into failure because
> it's not getting an adequate supply of CoQ10. The body does produce
> a certain amount of CoQ10, but as you age or have illness, the
> body's manufacture of CoQ10 decreases, that's why we supplement.
> So, if you are going to stop your CoQ10, please do it very slowly.
> Again, members who know more about this drug/CoQ10 interaction,
> please add your thoughts.
> Carol and Snowball and the gang
Executive Program Manager
UNC-Chapel Hill AGEP
Department of Chemistry
Kenan Labs, CB#3290
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