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1334Re: [feline-heart] crf and high blood pressure

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  • Laura Penny
    Jan 3, 2001
      Thanks for the article! We've had excellent results with Norvasc (along with
      Diltiazem) in our two HCM/CRF/hypertension kitties. Lower blood pressure has
      meant better kidney values.

      Laura, Lucky & Kassy

      -----Original Message-----
      From: Agnes Moscrip <anyes@...>
      To: crflist crflist <feline-crf@...>;
      feline-heart@egroups.com <feline-heart@egroups.com>
      Date: Wednesday, January 03, 2001 12:05 AM
      Subject: [feline-heart] crf and high blood pressure

      >The following site has an excellent discussion on the importance of
      >controlling high blood pressure and its effect on the kidneys.
      >Increased blood flow to the kidneys improve kidneys condition and this
      >was my personal observation after getting treatment for my crf/hcm/hbp
      >kitty. The text is geared to humans and modified by Dr. Newman DVM...
      >It also has an excellent discussion on kidney disease, its causes and
      >I hope that helps,
      >Anyes, angel Lucie, Georgina and Angelica
      >...''Control of systemic hypertension. Systemic hypertension is an
      >important mediator of progressive renal injury; there is unequivocal
      >evidence that lowering elevated BP slows the progression of renal
      >disease, especially in patients with proteinuria. A subgroup analysis
      >of MDRD study data showed that, in patients with urinary protein
      >excretion >1 g/day, the rate of decline in renal function was slowest
      >in those whose BP was maintained at 125/75 mm Hg.[9] In patients
      > without proteinuria there appeared to be little additional renal
      >benefit to maintaining BP below 135/85 mm Hg...."
      >..."In sum, ACE inhibitors slow the progression of renal failure in
      >patients with a wide variety of renal diseases and should be started
      >early in the course. Patients with proteinuria are likely to derive the
      >greatest benefit. The risk of adverse reactions is small but warrants
      >close monitoring after the start of therapy. The specific agent used is
      >not important, provided ppropriate dosage adjustments for renal
      >dysfunction are made when necessary.
      >Use of calcium channel blockers. Although not as well studied as the
      >ACE inhibitors, CCBs may also have renoprotective properties. The
      >mechanism of this protective effect may differ between the
      >dihydropyr-idines (eg, amlodipine, nifedipine, felodipine) and other
      >CCBs such as verapamil or diltiazem. The latter two drugs may reduce
      >intraglo-merular pressure in a manner similar to that of ACE
      >inhibitors; studies in patients with renal disease have shown that
      >these drugs, as compared with the ß blocker atenolol, led to a greater
      >reduction in proteinuria and a slower progression of renal disease. One
      >study has demonstrated an additive reduction in proteinuria when a
      >low-dose ACE inhibitor and verapamil were combined."...
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