1333crf and high blood pressure
- Jan 2, 2001The following site has an excellent discussion on the importance of
controlling high blood pressure and its effect on the kidneys.
Increased blood flow to the kidneys improve kidneys condition and this
was my personal observation after getting treatment for my crf/hcm/hbp
kitty. The text is geared to humans and modified by Dr. Newman DVM...
It also has an excellent discussion on kidney disease, its causes and
I hope that helps,
Anyes, angel Lucie, Georgina and Angelica
...''Control of systemic hypertension. Systemic hypertension is an
important mediator of progressive renal injury; there is unequivocal
evidence that lowering elevated BP slows the progression of renal
disease, especially in patients with proteinuria. A subgroup analysis
of MDRD study data showed that, in patients with urinary protein
excretion >1 g/day, the rate of decline in renal function was slowest
in those whose BP was maintained at 125/75 mm Hg. In patients
without proteinuria there appeared to be little additional renal
benefit to maintaining BP below 135/85 mm Hg...."
..."In sum, ACE inhibitors slow the progression of renal failure in
patients with a wide variety of renal diseases and should be started
early in the course. Patients with proteinuria are likely to derive the
greatest benefit. The risk of adverse reactions is small but warrants
close monitoring after the start of therapy. The specific agent used is
not important, provided ppropriate dosage adjustments for renal
dysfunction are made when necessary.
Use of calcium channel blockers. Although not as well studied as the
ACE inhibitors, CCBs may also have renoprotective properties. The
mechanism of this protective effect may differ between the
dihydropyr-idines (eg, amlodipine, nifedipine, felodipine) and other
CCBs such as verapamil or diltiazem. The latter two drugs may reduce
intraglo-merular pressure in a manner similar to that of ACE
inhibitors; studies in patients with renal disease have shown that
these drugs, as compared with the ß blocker atenolol, led to a greater
reduction in proteinuria and a slower progression of renal disease. One
study has demonstrated an additive reduction in proteinuria when a
low-dose ACE inhibitor and verapamil were combined."...
- Next post in topic >>