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Rhogam and Mercury

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  • Donna
    It should be noted that this research study compared equal doses of methylmercury and thimerosal. However, thimerosal is only 1/2 mercury (ethylmercury), so
    Message 1 of 1 , May 12, 2004
      It should be noted that this research study compared equal doses of
      methylmercury and thimerosal. However, thimerosal is only 1/2 mercury
      (ethylmercury), so the authors should have compared 1/2 dose
      thimerosal
      with 1 dose methylmercury. The conclusion would then be that
      ethylmercury is equally potent to methylmercury in increasing Ca2++.
      The
      study also says that unlike methylmercury (which is usually bound to
      cysteine in a cell) thimerosal's potency is unaffected by presence of
      L-cysteine in the neuron, so under in vivo conditions the effects of
      ethylmercury are likely greater (by a factor or 2) than methyl.
      Finally,
      the study shows that thimerosal is more potent than methyl in
      decreasing
      glutathione levels in the cell, which is what other researchers
      have/are
      finding as well.



      --- In lennoxgastaut@yahoogroups.com, "Donna" <dma_nc1@h...> wrote:
      > Methyl-mercury, usually from contaminated food, is very dangerous
      to
      > pregnant women. Methyl-mercury causes profound mental retardation,
      > cerebral
      > palsy, seizures, spasticity, tremors, and incoordination, along
      with
      > eye and
      > hearing damage in the unborn baby as a result of the mother's
      > exposure.
      > Organic mercury passes into the breast milk as well.
      >
      >
      >
      > The effect of thimerosal, an organomercurial preservative in
      > vaccines, on cerebellar neurons dissociated from 2-week-old rats
      was
      > compared with those of methylmercury using a flow cytometer with
      > appropriate fluorescent dyes. Thimerosal and methylmercury at
      > concentrations ranging from 0.3 to 10 microM increased the
      > intracellular concentration of Ca2+ ([Ca2+]i) in a concentration-
      > dependent manner. The potency of 10 microM thimerosal to increase
      > the [Ca2+]i was less than that of 10 microM methylmercury. Their
      > effects on the [Ca2+]i were greatly attenuated, but not completely
      > suppressed, under external Ca(2+)-free condition, suggesting a
      > possibility that both agents increase membrane Ca2+ permeability
      and
      > release Ca2+ from intracellular calcium stores. The effect of 10
      > microM thimerosal was not affected by simultaneous application of
      30
      > microM L-cysteine whereas that of 10 microM methylmercury was
      > significantly suppressed. The potency of thimerosal was similar to
      > that of methylmercury in the presence of L-cysteine. Both agents
      at
      > 1 microM or more similarly decreased the cellular content of
      > glutathione in a concentration-dependent manner, suggesting an
      > increase in oxidative stress. Results indicate that thimerosal
      > exerts some cytotoxic actions on cerebellar granule neurons
      > dissociated from 2-week-old rats and its potency is almost similar
      > to that of methylmercury.
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