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biochemical characterization/protein sequences of the Campanian hadrosaur Brachylophosaurus canadensis

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  • stephanpickering@cs.com
    Mary H. Schweitzer, Wenxia Zheng, C.L. Organ, Recep Avci, Zhiyong Suo, Lisa M. Freimark, Valerie S. Lebleu, M.B. Duncan, M.G.V. Heiden, J.M. Neveu, W.S. Lane,
    Message 1 of 1 , Apr 30, 2009
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      Mary H. Schweitzer, Wenxia Zheng, C.L. Organ, Recep Avci, Zhiyong Suo, Lisa M. Freimark, Valerie S. Lebleu, M.B. Duncan, M.G.V. Heiden, J.M. Neveu, W.S. Lane, J.C. Cottrell, J.R. Horner, L.C. Cantley, Raghu Kalluri, J.M. Asara, 2009. Biochemical characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science 324:626-631 + Supporting Online Material [Materials & methods, SOM Text, Figs. S1-S12, Table S1, References, Appendix S1 (48pp) + Database S1 (zipped archive)]. ABSTRACT. Molecular preservation in non-avian dinosaurs is controversial. We present multiple lines of evidence that endogenous proteinaceous material is preserved in bone fragments and soft tissues from an 80-million-year-old Campanian hadrosaur, Brachylophosaurus canadensis [Museum of the Rockies (MOR) 2598]. Microstructural and immunological data are consistent with preservation of multiple bone matrix and vessel proteins, and phylogenetic analyses of Brachylophosaurus collagen sequenced by mass spectrometry robustly support the bird-dinosaur clade, consistent with an endogenous source for these collagen peptides. These data complement earlier results from Tyrannosaurus rex (MOR 1125) and confirm that molecular preservation in Cretaceous dinosaurs is not a unique event.
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      STEPHAN PICKERING / Chofetz Chayim ben-Avraham

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