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Temperature-Sensing Fat Cells

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  • james kohl
    Temperature-Sensing Fat Cells By Dan Cossins | July 1, 2013 Excerpt: Researchers discover that unlike brown fat cells, white fat cells can directly sense
    Message 1 of 1 , Jul 2, 2013

      Temperature-Sensing Fat Cells

      By Dan Cossins | July 1, 2013

      Excerpt: Researchers discover that unlike brown fat cells, white fat cells can directly sense cooling temperatures to switch on genes that control heat production.

      My comment: The study reports findings consistent with what is currently known about Nutrient-dependent / Pheromone-controlled thermodynamics and thermoregulation (prepublication), which is exemplified in model organisms that now include a human population.  Kamberov et al and Grossman et al detailed the adaptive evolution of a population in what is now central China.

      A single nutrient-dependent amino acid substitution incorporates what is currently known about the thermodynamics of intracellular signaling, internuclear interactions, and stochastic gene expression of de novo genes via alternative splicings that result in organism-level thermoregulation (in species from microbes to man). Cause and effect is established through the conserved molecular mechanisms for adaptive evolution (i.e., via ecological, social, neurogenic, and socio-cognitive niche construction). See for example: Nutrient--dependent / pheromone--controlled adaptive evolution: a model (published 6/14/13).

      I suspect it will not be long until nutrient-dependent thermodynamic control of antibiotic resistence in E. Coli  -- and perhaps in other gram negative or gram positive organisms -- will be linked to cause of death by sepsis in cases where the organism more effectively thermoregulates than the individual it kills. Unfortunately, however, I don't know of anyone not associated with Bonnie Bassler who is examining aspects of quorum-sensing in bacteria, which will lead to incorporating nutrient-dependent pheromone-controlled reproduction of microbes in the treatment of human bacterial diseases and possibly in obesity-linked cancer et al.

      The problem appears to be that evolutionary theorists have convinced many people mutations somehow cause adaptive evolution, which suggests they also somehow cause obesity-linked cancer and other conditions known to result from conserved molecular mechanisms of health and disease in species from microbes to man. My recent 2-year's of medical laboratory experience in microbiology led to the not-altogether-surprising realization that microbes were causing things like adaptive evolution (or death) that mutations could not possibly cause.
       
      James V. Kohl
      Medical laboratory scientist (ASCP)
      Independent researcher
      Kohl, J.V. (2013) Nutrient-dependent/pheromone-controlled adaptive evolution: a model. Socioaffective Neuroscience & Psychology, 3: 20553.
      Kohl, J.V. (2012) Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. Socioaffective Neuroscience & Psychology, 2: 17338.
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