quantum theory for their replaceable role of
docosahexaenoic acid in
cell signalling throughout evolution
A.Crawford, C.Leigh Broadhurst, Martin Guest,
Atulya Nagar, Yiqun
Kebreab Ghebremeskel, Walter F.Schmidt
Ma the fossil record displays the sudden
appearance of intra-cellular
& the 32 phyla.
Cambrian Explosion marks the onset of dominant
intra-cellular structures are so similar to
extant organisms that
were likely made with similar membrane lipids
& proteins, which
provided for organisation & specialisation.
amino acids could be synthesised >4000 Ma,
only oxidative metabolism
for the synthesis of highly unsaturated fatty
acids, thus producing
lipid molecular species for specialised cell
provided the core for the development of the
of photons into electricity stimulated the
evolution of the
system & brain.
then, DHA has been conserved as the principle
acyl component of
synaptic & neuronal signalling membranes in
fish, amphibian, reptiles, birds, mammals &
extreme conservation in electrical signalling
membranes - despite
genomic change - suggests it was DHA dictating
to DNA, rather than
generally accepted other way around.
offer a theoretical explanation, based on the
of DHA for such extreme conservation.
unique molecular structure of DHA allows for
quantum transfer &
of p-electrons, which explains the precise
membranes and the cohesive organised neural
cell membrane lipid bi-layer is the home of
about 1/3 of all known
are the transporters, ion channels, receptors
& signalling systems,
are dependent on the lipid domains in which they
species, organ & even sub-cellular
specificity of lipids testifies to
demands of differentiated cells & precise
membrane lipid composition is different for the
kidneys, liver & brain.
within a given tissue, there are specific
differences in the plasma
compared to the mitochondria & nuclear
highly specific, characteristic differences in
the plasma membranes of
neural, endo- & epithelial cells; or
glomerulus & distal tubules of
kidneys, cannot be based on vague compositional
propose this constancy & specificity is a
function of specific
interactions operating in a multi-dimensional
to what has been described for proteins.
relationship has to be a 2-way system.
cell differentiation, the specialist proteins
that arrive will seek
lipid match & v.v.
the matching lipids are not present, the system
may fail, regardless of
are built with 20 Aas that are assembled into 3D
of the molecular motion of the final protein
assembly, it is an
of supra-molecular chemistry, which includes
& electro-chemical effects involving
structures. In that sense a protein in a living
cell exists in
Dimension: electro-chemical profile.
Dimension: vanderWaals type forces.
& Essential Fatty Acids