20822Re: [evol-psych] How the brain forgets
- Sep 30, 2002I'm not a neurologist, psychiatrist, endocrinologist, etc., but it seems that two relevant topics for investigation, that could have important medical implications for this new data, include:
1) interactions (if any) between PP1 and hormone levels in menopausal women, and,
2) interactions (if any) between PP1 and neurotransmitters, such as serotonin, melatonin, or other brain chemicals implicated in depression and age-related insomnia.
Is anyone aware of such work in progress?
Deborah Lindley, Wildlife Ecologist
Land Management Division
Washington Dept.of Natural Resources
P. O. Box 47014
Olympia, Washington 98504-7014
(360) 902-1374 <deborah.lindley@...>
>>> "Ian Pitchford" <ian.pitchford@...> 08/29/02 05:56 a >>>BBC News Online
Thursday, 29 August, 2002, 10:48 GMT 11:48 UK
How the brain forgets
Scientists have found a molecule that may be to blame for loss of memory as we
It raises the tempting prospect of new therapies to restore memory.
The enzyme helps the brain delete unwanted information.
But a team from the Swiss Federal Institute of Technology in Zurich believe it
may become too active as we get older.
The researchers carried out tests on mice that showed those animals with low
levels of the enzyme, called protein phosphatase-1 (PP1), were less likely to
forget what they had learned.
It appears that PP1 actively suppresses memories in mice, both during and after
a learning exercise.
And as the mice get older, the level of PP1 increases.
When the scientists blocked the action of PP1 the mice recovered their full
learning and memory abilities.