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Brin: Calorie Restriction

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  • KZK
    http://www.sciencedaily.com/releases/2012/11/121121145404.htm The vacuole -- and its counterpart in humans and other organisms, the lysosome -- has two main
    Message 1 of 1 , Dec 5, 2012
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      http://www.sciencedaily.com/releases/2012/11/121121145404.htm

      The vacuole -- and its counterpart in humans and other organisms, the
      lysosome -- has two main jobs: degrading proteins and storing molecular
      building blocks for the cell. To perform those jobs, the interior of the
      vacuole must be highly acidic.

      Hughes and Gottschling found that the vacuole becomes less acidic
      relatively early in the yeast cell's lifespan and, critically, that the
      drop in acidity hinders the vacuole's ability to store certain
      nutrients. This, in turn, disrupts the mitochondria's energy source,
      causing them to break down. Conversely, when Hughes prevented the drop
      in vacuolar acidity, the mitochondria's function and shape were
      preserved and the yeast cells lived longer.

      "Until now, the vacuole's role in breaking down proteins was thought to
      be of primary importance. We were surprised to learn it was the storage
      function, not protein degradation, that appears to cause mitochondrial
      dysfunction in aging yeast cells," Hughes said.

      The unexpected discovery prompted Hughes and Gottschling to investigate
      the effects of calorie restriction, which is known to extend the
      lifespan of yeast, worms, flies and mammals, on vacuolar acidity. They
      found that calorie restriction -- that is, limiting the raw material
      cells need -- delays aging at least in part by boosting the acidity of
      the vacuole.


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      "It’s cheap to maintain Lies and expensive to maintain Trvth."
      --KZK's Maxim

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