Loading ...
Sorry, an error occurred while loading the content.

Toxicity of Cerium Oxide Nanoparticles in Human Lung Cancer Cells

Expand Messages
  • Joschka Fisher
    Toxicity of Cerium Oxide Nanoparticles in Human Lung Cancer Cells Weisheng Lin A1, Yue-wern Huang A2, Xiao-Dong Zhou A3, Yinfa Ma A1 A1 Department of Chemistry
    Message 1 of 1 , Dec 4, 2006
    • 0 Attachment
      Toxicity of Cerium Oxide Nanoparticles in Human Lung
      Cancer Cells


      Weisheng Lin A1, Yue-wern Huang A2, Xiao-Dong Zhou A3,
      Yinfa Ma A1

      A1 Department of Chemistry and Environmental Research
      Center for Emerging Contaminants, University of
      Missouri-Rolla, Rolla, Missouri, USA
      A2 Department of Biological Sciences and Environmental
      Research Center for Emerging Contaminants, University
      of Missouri-Rolla, Rolla, Missouri, USA
      A3 Pacific Northwest National Laboratory, Richland,
      Washington, USA

      Abstract:


      With the fast development of nanotechnology, the
      nanomaterials start to cause people's attention for
      potential toxic effect. In this paper, the
      cytotoxicity and oxidative stress caused by 20-nm
      cerium oxide (CeO2) nanoparticles in cultured human
      lung cancer cells was investigated. The sulforhodamine
      B method was employed to assess cell viability after
      exposure to 3.5, 10.5, and 23.3 μg/ml of CeO2
      nanoparticles for 24, 48, and 72 h. Cell viability
      decreased significantly as a function of nanoparticle
      dose and exposure time. Indicators of oxidative stress
      and cytotoxicity, including total reactive oxygen
      species, glutathione, malondialdehyde,
      α-tocopherol, and lactate dehydrogenase, were
      quantitatively assessed. It is concluded from the
      results that free radicals generated by exposure to
      3.5 to 23.3 μg/ml CeO2 nanoparticles produce
      significant oxidative stress in the cells, as
      reflected by reduced glutathione and α-tocopherol
      levels; the toxic effects of CeO2 nanoparticles are
      dose dependent and time dependent; elevated oxidative
      stress increases the production of malondialdehyde and
      lactate dehydrogenase, which are indicators of lipid
      peroxidation and cell membrane damage, respectively.

      Keywords:

      Cerium Oxide (CeO2), Cytotoxicity, Lung Cancer Cells
      (A549), Nanoparticles, Oxidative Stress

      The references of this article are secured to
      subscribers.



      Title: Toxicity of Cerium Oxide Nanoparticles in
      Human Lung Cancer
      Cells
      Author(s): Weisheng Lin, Yue-wern Huang, Xiao-Dong
      Zhou, et al.
      Source: International Journal of Toxicology
      ISSN: 1091-5818
      Issue: Volume 25, Issue Number 6/November-December
      2006 pages: 451
      - 457

      http://taylorandfrancis.metapress.com/link.asp?ID=M605MV14078U06P3

      This article is available to subscribers and also via
      pay per view. If
      you have any problems accessing this page please
      contact:
      support@...

      Sign up for free table of contents alerts from Taylor
      & Francis. To
      register, visit: http://www.tandf.co.uk/SARA






      ___________________________________________________________________________
      Découvrez une nouvelle façon d'obtenir des réponses à toutes vos questions !
      Profitez des connaissances, des opinions et des expériences des internautes sur Yahoo! Questions/Réponses
      http://fr.answers.yahoo.com
    Your message has been successfully submitted and would be delivered to recipients shortly.