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RTM: aspartame in Merck Maxalt-MLT worsens migraine, AstraZeneca Zomig, Eli Lilly Zyprexa, J&J Merck Pepcid AC (Famotidine 10mg) Chewable Tab, Pfizer Cool Mint Listerine Pocketpaks 7.16.2 rmforall

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  • Rich Murray
    RTM: aspartame in Merck Maxalt-MLT worsens migraine, AstraZeneca Zomig, Eli Lilly Zyprexa, J&J Merck Pepcid AC (Famotidine 10mg) Chewable Tab, Pfizer Cool Mint
    Message 1 of 1 , Jul 16, 2002
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      RTM: aspartame in Merck Maxalt-MLT worsens migraine,
      AstraZeneca Zomig, Eli Lilly Zyprexa,
      J&J Merck Pepcid AC (Famotidine 10mg) Chewable Tab,
      Pfizer Cool Mint Listerine Pocketpaks 7.16.2 rmforall

      http://groups.yahoo.com/group/aspartameNM/message/846
      *************************************************************

      http://groups.yahoo.com/group/aspartameNM/message/752
      Headache 2001 Oct;41(9):899-901
      Migraine MLT-Down: An Unusual Presentation of Migraine
      in Patients With Aspartame-Triggered Headaches.
      [Merck 10-mg Maxalt-MLT, for migraine, has 4 mg aspartame,
      while 12 oz diet soda has 200 mg.]
      Newman LC, Lipton RB. RLipton@...
      Headache Institute, St. Lukes-Roosevelt Hospital Center, New York
      NY Department of Neurology
      Albert Einstein College of Medicine, Bronx, NY
      Innovative Medical Research
      *************************************************************

      RTM: Horner: Pfizer Inc hides behind FDA re aspartame 5.29.2 rmforall
      http://groups.yahoo.com/group/aspartameNM/message/831

      Subject: RE: aspartame
      Date: Wed, 29 May 2002 10:38:53 -0400
      From: Consumer Affairs #1 <ConAff1@...>
      To: "'Rich Murray'" <rmforall@...>

      Dear Mr. Murray,

      Thank you for contacting Pfizer Inc regarding our usage of aspartame
      in some of our products.
      The FDA began approving the use of aspartame in new prescription drug
      products over 10 years ago.*
      Its' use continues in both life-sustaining and life-saving products
      for both adult and pediatric use.**
      It is also widely used as a sweetener in over-the-counter drug
      products.***
      The FDA has approved the use of aspartame as a sweetening agent
      and flavor enhancer in food products including, but not limited to,
      baked goods, baking mixes, carbonated beverages and beverage mixes.****
      Given the number of acceptable alternatives to this sweetener,
      if the FDA had any safety concerns with aspartame,
      they would withdraw the approval for this sweetener immediately.*****

      * The 1996 copy of the FDA's Inactive Ingredient Guide cites an NDA
      drug, using aspartame as an inactive ingredient,
      with an approval date of 12/23/91.

      ** Recent Rx drug approvals for which aspartame was an inactive
      ingredient include Singulair Chewable Tablets, Zyvox Oral Suspension,
      Videx Chewable Tablets and Amoxil Chewable Tablets.

      ***OTC products include Tylenol Cold Chewable Tablets Triaminic
      Softchews, TheraFlu Flu & Sore Throat Powder, Children's Advil Chewable
      Tablets and Children's Motrin Chewable Tablets.

      ****21 CFR 172.804 and Federal Register, June 28, 1996 (Volume 61,
      Number 126, pages 33654-33656).

      *****Given what FDA did with phenylpropanolamine, this is a given.

      For further assistance, please call one of our representatives at
      1-800-223-0182 (U.S.) or 1-800-661-4659 (Canada),
      weekdays between 9 a.m. and 5 p.m. EST or reply by e-mail.

      Chip Horner, Senior Director Consumer Affairs Department Pfizer Inc /tp

      -----Original Message-----
      From: Rich Murray [mailto:rmforall@...]
      Sent: Tuesday, May 28, 2002 12:56 AM
      To: Consumer Affairs #1; william.kirkland@...
      Subject: RTM: aspartame toxicity: recent research 5.27.2 rmforall
      *************************************************************

      http://www.zomig.com/
      AstraZeneca Pharmaceuticals LP
      ZOMIG is indicated for the acute treatment of migraine with or without
      aura in adults.
      Because ZOMIG is prescription medicine, only your doctor or health care
      provider can help you decide whether it's right for you..
      Patients with the inability to process the amino acid phenylalanine
      should be aware that each 2.5 mg and 5 mg ZOMIG-ZMTTM(zolmitriptan)
      Orally Disintegrating Tablet contains 2.81 mg and 5.62 mg of
      phenylalanine (a component of aspartame), respectively.
      ************************************************************

      pi.lilly.com/zyprexa-pi.pdf
      www.zyprexa-side-effects.com/
      Eli Lilly and Company Zyprexa (olanzapine) antipsychotic
      ************************************************************

      http://www.pepcidac.com/
      Johnson & Johnson - Merck Consumer Pharmaceuticals Co.
      Mint-flavored Chewable tablets
      Tracey Ely <pwebmast@...>
      PEPCID AC Consumer Relationship Center
      *************************************************************

      Nov 18 2001 Hello, Merck needs to take action regarding the research
      by two eminent reserchers, L.C. Newman and R.B. Lipton, that the
      4.20 mg aspartame in each $ 14 10-mg tablet of Maxalt-MLT, a potent
      migraine drug, worsens migraine in some people.
      While this dose is just 2% of the 200 mg aspartame in 16 oz of diet
      soda, its toxicity may be increased by direct absorption,
      as the wafer melts in the mouth.
      Aspartame reactors often have severe symtoms from a single stick of
      chewing gum.

      Dennis Choi, PhD, your new Exec. VP, Neurosciences, who has a
      particular expertise on excitotoxicity, is well qualified to assess
      this problem. The end of this post offers a summary of informed
      experts.
      I hope this information is helpful.

      Best regards, Rich Murray Room For All rmforall@...
      1943 Otowi Road Santa Fe New Mexico 87505
      *************************************************************

      http://groups.yahoo.com/group/aspartameNM/message/752
      RTM: Newman & Lipton:
      aspartame triggers & worsens migraine 11.17.1 rmforall

      Headache 2001 Oct;41(9):899-901
      Migraine MLT-Down: An Unusual Presentation of Migraine in Patients With
      Aspartame-Triggered Headaches.
      Newman LC, Lipton RB.
      Headache Institute, St. Lukes-Roosevelt Hospital Center, New York
      NY Department of Neurology
      Albert Einstein College of Medicine, Bronx, NY
      Innovative Medical Research

      Aspartame, an artificial sweetener added to many foods and beverages,
      may trigger headaches in susceptible individuals.
      We report two patients with aspartame-triggered
      attacks in whom the use of an
      aspartame-containing acute medication (Maxalt-MLT) worsened
      an ongoing attack of migraine. PMID: 11703479

      http://www.docnet.org/physicians/phys_bios.asp?phys_id=574
      Lawrence C. Newman, MD 212-523-5869
      St. Luke's-Roosevelt Hospital Center
      Headache Institute
      1000 10th Avenue, Room 1C-10
      New York, NY 10019
      Prof. Neurology, Epidemiology & Social Medicine
      Albert Einstein College of Medicine at Yeshiva University

      http://msl.montefiore.org/newmsl/default.htm
      Dr. Richard B. Lipton, Department of Neurology RLipton@...
      Montefiore Medical Center
      111 East 210th Street, Bronx, NY 10467, USA.
      FAX 203-321-1044
      Albert Einstein College of Medicine
      1300 Morris Park Avenue
      Bronx, NY 10461
      718-430-3886 fax 3870
      MMC - Headache Unit
      111 E. 210th Street Bronx , NY 10467 718-920-4638

      http://www.imrinc.com/ webmaster@...
      Innovative Medical Research, Inc.
      Alberto R. Yataco, M.D.
      Richard B. Lipton, M.D., Chief Science Officer RLipton@...
      1001 Cromwell Bridge Rd., Suite 302
      Towson, MD 21286 USA
      410-825-0500 Fax: 410-339-7086
      http://www.centerwatch.com/professional/pro111.html

      Merck and Co., Inc. http://www.merck.co

      Peter S. Kim, PhD Exec. VP, R&D age 43
      kimadmin@... 617-258-5184 fax 5737
      MRL 770 Sunnytown Pike West Point PA 19486

      Edward M. Scolnick, MD Exec. VP, Sci & Tech, Pres. of MRL age 61
      MRL P.O.Box 2000 Rayway, NJ 07065-0900 732-594-3761

      William A. Peck, MD Exec V. Chancellor for medical affairs WUSOM
      peckw@... 314-362-6827

      Bennett M. Shapiro, MD, Exec. VP, Merck Worldwide Basic Research
      732-594-3761

      Raymond V. Gilmartin, CM, Pres., CEO, Merck & Co., Inc.
      One Merck Drive P.O.Box 100 Whitehouse Station, NJ 08889-0100
      fax 908-735-1253

      Merck's $ 15M alliance with MIT:

      Prof. Phillip A. Sharp sharppa@... 617-253-6421

      Prof. Nancy H. Hopkins nhopkins@... 617-253-6414, 6408

      Prof. Daniel I.C. Wang dicwang@... 617-253-2126, 0805

      Robert L. Malster malster@... 617-253-2703

      Kennth D. Campbell, Dir., MIT News kdc@... 617-253-2703

      Carol Goodrich, Merck, Manager, Corp. Comm. 908-423-6022

      Janet Skidmore, Merck, research news 908-423-3046

      Jan Weiner, Merck, US products news 267-305-6462

      http://www.neuro.wustl.edu/people/choi.html
      Home Page
      Dennis Wonkyu Choi, MD, PhD age 48
      Hired Nov 13 2001 by Merck Research Labortories as Executive VP,
      Neurosciences
      Dennis Choi is the Andrew B. and Gretchen P. Jones Professor
      and Head of the Department of Neurology at
      Washington University in St. Louis, as well as
      the Neurologist-in-Chief at Barnes-Jewish Hospital. 866-867-3627 info

      BIOGRAPHICAL SKETCH
      Dr. Choi was born in Ann Arbor, Michigan, and grew up in Watertown,
      Massachusetts. He graduated from Harvard College in 1974, and in 1978
      received the MD and PhD degrees (the latter in Pharmacology) from
      Harvard University and the Harvard-MIT Program in Health Sciences and
      Technology. After completing residency and fellowship training in
      neurology at Harvard in 1983, he joined the faculty at Stanford
      University, and then 1991 came to Washington University Medical School
      to chair the Neurology Department. At Washington University, he also
      directs the Center for the Study of Nervous System Injury and the
      McDonnell Center for Cellular and Molecular Neurobiology. He is the
      chairman of the US / Canada Regional Committee of the International
      Brain Research Organization, a past President
      of the Society for Neuroscience, and a past Vice-President of the
      American Neurological Association. He is a member of the Institute of
      Medicine, and has served on the Councils of the National Institute of
      Neurological Disorders and Stroke, the Society for Neuroscience, the
      Winter Conference for Brain
      Research, the International Society for Cerebral Blood Flow and
      Metabolism, and the Neurotrauma Society.

      He is a member of the editorial boards of more than a dozen journals
      including Science, and is a founding co-editor of Neurobiology of
      Disease, a journal
      positioned at the interface of basic and clinical neuroscience. He is
      presently an Associate of the Neurosciences Institute in San Diego
      and a member of the
      Dana Alliance for Brain Research.
      Current or past service on scientific advisory boards has included the
      Christopher Reeve Paralysis Foundation, the Grass Foundation,
      the Hereditary Disease Foundation, the Queen's
      Neuroscience Institute in Honolulu, the Max-Planck Institute in
      Heidelberg, the Korea Institute for Advanced Study (KIAS) in Seoul, and
      the US Food and Drug Agency, as well as several university-based
      research consortia in the US and Europe, and several companies.

      RESEARCH SUMMARY
      The work of my laboratory is directed toward elucidating the cellular
      mechanisms underlying CNS injury in neurological disease states, and
      developing therapeutic countermeasures. A long-standing interest has
      been the "excitotoxic" neuronal injury produced by excess exposure to
      glutamate and other endogenous excitatory amino acids. Excitotoxicity
      likely contributes to the brain or spinal cord damage induced by
      hypoxia-ischemia, trauma, or seizures, and may also play a role in the
      pathogenesis of some neurodegenerative diseases, such as Huntington's
      disease or motor neuron disease.

      Prior work from the laboratory implicated calcium overload and NMDA
      receptor activation in pathogenesis of excitotoxic cell death. In more
      recent years, investigation has broadened to include other
      perturbations in cationic homeostasis,
      the interrelationship between excitotoxicity
      and apoptosis, and downstream injury pathways including free radical
      generation. My colleagues and I hypothesize that endogenous brain zinc
      stores may also mediate neuronal death under some pathological
      conditions, and that potassium efflux via voltage- or glutamate-gated
      channels may promote neuronal apoptosis. We have also examined the
      possibility that certain growth factor may enhance, rather than
      reduce, excitotoxic neuronal death. A recent line of research,
      conducted in collaboration with several other laboratories at Washington
      University and elsewhere,
      explores strategies for promoting recovery after rodent
      spinal cord injury utilizing stem cell transplantation.

      choid@... 314-362-7175

      CONTACT INFORMATION
      E-mail: wildersp@...
      (314) 362-9460 Fax: (314) 362-9462
      Washington University School of Medicine
      660 S. Euclid Campus Box 8111 St. Louis, MO 63110
      ************************************************************

      Rich Murray, MA Room For All rmforall@...
      1943 Otowi Road, Santa Fe NM USA 87505 505-986-9103

      http://groups.yahoo.com/group/aspartameNM/messages for 846 posts
      http://groups.yahoo.com/group/aspartameNM/message/657 45K post
      http://groups.yahoo.com/group/aspartameNM/message/763 30K post

      http://groups.yahoo.com/group/aspartameNM/message/845
      RTM: Martini: heroic month march in UK against aspartame 7.14.2 rmforall

      http://groups.yahoo.com/group/aspartameNM/message/844
      RTM: layman lament: NutraSweet: aspartame & neotame toxicity 7.12.2
      rmforall

      http://groups.yahoo.com/group/aspartameNM/message/840
      RTM: NutraSweet Co.: Neotame toxicity questions 7.9.2 rmforall

      http://groups.yahoo.com/group/aspartameNM/message/841
      RTM: Merisant Co., MSD Capital, Dell Computer Corp., NutraSweet Co.,
      JW Childs Assc.: aspartame-neotame toxicity 7.10.2 rmforall

      http://groups.yahoo.com/group/aspartameNM/message/830
      RTM: Tholen: Diet Coke has 5 ppm formaldehyde from aspartame
      5.29.2 rmforall
      For 6 cans of diet soda, this is 5 times the daily limit of 1 PPM for
      formaldehyde in drinking water, set by the EPA and the
      California Dept. of Health Services,
      Div. Drinking Water and Environmental Management (916) 323-2308
      Drinking Water Action Levels: Contaminants of Current Interest
      Last Update: May 2, 2002

      http://www.dorway.com/tldaddic.html 5-page review
      "Aspartame (NutraSweet) Addiction"
      H.J. Roberts in "Townsend Letter", Jan 2000 HJRobertsMD@...
      http://www.sunsentpress.com/ sunsentpress@...
      Sunshine Sentinel Press P.O.Box 17799 West Palm Beach, FL 33416
      800-814-9800 561-588-7628 561-547-8008 fax

      http://groups.yahoo.com/group/aspartameNM/message/669
      1038-page medical text "Aspartame Disease: An Ignored Epidemic"
      published May 30 2001 $ 85.00 postpaid data from 1200 cases
      available at http://www.amazon.com
      over 600 references from standard medical research
      http://www.aspartameispoison.com/contents.html 34 chapters
      http://groups.yahoo.com/group/aspartameNM/message/790
      RTM: Moseley:
      review Roberts "Aspartame Disease: An Ignored Epidemic" 2.7.2 rmforall

      http://groups.yahoo.com/group/aspartameNM/message/652
      Ann Pharmacother 2001 Jun;35(6):702-6
      Relief of fibromyalgia symptoms following
      discontinuation of dietary excitotoxins.
      terpening@... cterpeni@...
      Smith JD, Terpening CM, Schmidt SO, Gums JG.
      Malcolm Randall Veterans Affairs Medical Center, Gainesville, FL, USA.
      gums@... siggy@...

      http://groups.yahoo.com/group/aspartameNM/message/782
      RTM: Smith, Terpening, Schmidt, Gums:
      full text: aspartame, MSG, fibromyalgia 1.17.2 rmforall

      http://groups.yahoo.com/group/aspartameNM/message/804
      RTM: Hetle & Eltervaag: 2001 thesis
      abstract: aspartame brain damage in mice:
      Sonnewald 1995 study full text 2.17.2 rmforall

      http://groups.yahoo.com/group/aspartameNM/message/752
      Headache 2001 Oct;41(9):899-901
      Migraine MLT-Down: An Unusual Presentation of Migraine
      in Patients With Aspartame-Triggered Headaches.
      [Merck 10-mg Maxalt-MLT, for migraine, has 4 mg aspartame,
      while 12 oz diet soda has 200 mg.]
      Newman LC, Lipton RB. RLipton@...
      Headache Institute, St. Lukes-Roosevelt Hospital Center, New York
      NY Department of Neurology
      Albert Einstein College of Medicine, Bronx, NY
      Innovative Medical Research

      http://groups.yahoo.com/group/aspartameNM/message/346
      WebMD: Barclay: Barth:
      survey shows aspartame hurts memory in students 11.9.00
      http://www.psy.tcu.edu/psy/barth.htm
      Timothy M. Barth Department of Psychology t.barth@...
      Texas Christian University TCU Box 298920 Fort Worth, TX 76129
      Chairman, Physiological Psychology 817-921-7410

      http://groups.yahoo.com/group/aspartameNM/message/760
      Magnes Res 2001 Sep;14(3):189-94
      The effect of oral aspartame administration on the
      balance of magnesium in the rat.
      Kovatsi L, Tsouggas M.
      Laboratory of Forensic Medicine & Toxicology, Faculty of Medicine
      Aristotle University of Thessaloniki, Greece kovatsi@...

      http://groups.yahoo.com/group/aspartameNM/message/689
      Measurement of molecular interaction of aspartame and
      its metabolites with DNA. Clin Biochem. 1998 Jul;31(5):405-7.
      Karikas GA, Schulpis KH, Reclos GJ, Kokotos G.
      Dept. of Chemistry, University of Athens, Greece
      http://www.chem.uoa.gr gkokotos@...

      http://ww.presidiotex.com/barcelona/index.html
      Life Sci June 26 1998; 63(5): 337-49
      Formaldehyde derived from dietary aspartame binds to tissue
      components in vivo. ["Trok-ho"]
      Trocho C, Pardo R, Rafecas I, Virgili J, Remesar X,
      Fernandez-Lopez JA, Alemany M, Departament de Bioquimica i
      Biologia Molecular, Facultat de Biologia, Universitat de Barcelona,
      Spain. http://www.presidiotex.com/barcelona/index.html
      Maria Alemany, PhD alemany@...
      ************************************************************
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