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methanol has blood half-life 3 hours, made into uncontrolled formaldehyde inside cells of 20 tissues with high levels of ADH1 enzyme, harming inner walls of blood vessels -- WC Monte paradigm: Rich Murray 2014.02.18

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  • Rich Murray
    methanol has blood half-life 3 hours, made into uncontrolled formaldehyde inside cells of 20 tissues with high levels of ADH1 enzyme, harming inner walls of
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      methanol has blood half-life 3 hours, made into uncontrolled formaldehyde inside cells of 20 tissues with high levels of ADH1 enzyme, harming inner walls of blood vessels -- WC Monte paradigm: Rich Murray 2014.02.18


      Prof. Woodrow C. Monte, Food Science and Nutrition, Arizona State University, retired 2004, gives a free online archive of 782 full text medical references at WhileScienceSleeps.com...

      Major methanol sources are cigarette and wood smoke, aspartame, and fruits juices and vegetables in cans and jars.

      Methanol acts as a "Trojan horse" agent, releasing formaldehyde inside cells within 20 tissues in the adult and fetus -- random epigenetic modification is the major toxic process, initiating many chronic diseases and birth defects.

      Only humans cells lack a functioning biochemical defense against the ADH1 enzyme, in high levels in 20 tissues, rapidly making methanol into uncontrolled, free floating highly reactive acidic hydrated formaldehyde right inside the cytosol. Thus, humans are ten to a hundred times more vulnerable than any other creature.



      On Monday, February 10, 2014 4:03 PM, 
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      "A physician for more than 20 years, he is chairman of the Institute for Functional Medicine, as well as the founder and wellness director of the UltraWellness Center in Massachusetts."

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      [ These are all also methanol-formaldehyde toxicity symptoms... ]


      "Dr. Hyman is Chairman of the Institute for Functional Medicine, and was awarded its 2009 Linus Pauling Award for Leadership in Functional Medicine. He is currently medical editor at the Huffington Post and on the Medical Advisory Board at The Doctor Oz Show. He is on the Board of Directors of The Center for Mind-Body Medicine, and a faculty member of its Food As Medicine training program. He is also on the Board of Advisors of Memhet Oz’s HealthCorps, which tackles the obesity epidemic by “educating the student body” in American high schools about nutrition, fitness and mental resilience. He is a volunteer for Partners in Health with whom he worked immediately after the earthquake in Haiti and continues to help rebuild the health care system there. He was featured on 60 Minutes for his work there.

      Dr. Hyman has testified before the White House Commission on Complementary and Alternative Medicine, and has consulted with the Surgeon General on diabetes prevention. He has testified before the Senate Working Group on Health Care Reform on Functional Medicine, and participated in the White House Forum on Prevention and Wellness in June 2009. Dr. Hyman was nominated by Senator Tom Harkin for the President’s Advisory Group on Prevention, Health Promotion and Integrative and Public Health, a 25-person group to advise the Administration and the new National Council on Prevention, Health Promotion and Public Health.

      With Drs. Dean Ornish and Michael Roizen, Dr. Hyman crafted and helped to introduce the Take Back Your Health Act of 2009 into the United States Senate, to provide for reimbursement of lifestyle treatment of chronic disease. He continues to work in Washington on health reform, recently testifying before a Congressional hearing on Functional Medicine, nutrition and the use of dietary supplements. He has worked with President Clinton and the Clinton Foundation and presented at the Health Matters, Achieving Wellness in Every Generation."



      careful expert lifetime study on mice shows liver and lung cancers
      from aspartame, M Soffritti et al, Ramazzini Institute, Italy, checked
      by US National Toxicology Program experts, confirms many previous
      studies from 2001 on: Rich Murray 2011.02.27



      Prof. Erik Millstone 2013.12.16 crisp critique of EFSA blatant pro-industry bias on 2013.12.10 aspartame decision --  Sepp Hasslberger blog: Rich Murray 2014.01.07


      research on aspartame (methanol, formaldehyde, formic acid) toxicity: Rich Murray 2004.07.11 2014.01.21



      Methanol (wood alcohol) from cigarettes and aspartame circulates with blood half-life 3 hours, entering every cell -- made into uncontrolled formaldehyde inside cells with high ADH1 enzyme levels -- WC Monte paradigm: Rich Murray 2014.02.04


      similar macular harm in multiple sclerosis as from formaldehyde made by ADH enzyme inside retina capillary walls from methanol, Prof. Woodrow C. Monte text "While Science Sleeps" 2012 Jan -- some quotes re retina harm: Rich Murray 2012.05.10


      Only humans cells lack a functioning biochemical defense against the ADH1 enzyme, in high levels in 20 tissues, rapidly making methanol into uncontrolled, free floating highly reactive acidic hydrated formaldehyde right inside the cytosol. Thus, humans are ten to a hundred times more vulnerable than any other creature.


      Evidence exists that autism results from exposure to pregnant women in the fourth week, since ADH1 levels are high in the Purkinje cells of the vermis in the cerebellum, while other plausible birth defects include spina bifida, premature birth, and Fetal Alcohol Spectrum Disorder.


      The leading methanol sources are cigarette smoke and aspartame (E951).
      WC Monte gives 782 free full text medical research references at WhileScienceSleeps.com .


      California OEHHA sets methanol ingestion level 23 mg daily, same as from 1 can aspartame diet soda, 10 cigarettes, 3 tomatoes, or 4 cans green beans: Rich Murray 2013.07.03

      "However, the anticipated exposure to methanol from consumption of aspartame would not be considered an exposure within the meaning of Proposition 65 because aspartame is not listed under Proposition 65."

      [ Rich Murray: Many pregnant women drink one 12-oz can aspartame diet drink daily, with 200 mg aspartame that gives 11% methanol, 22 mg, which is just under the OEHHA limit of 23 mg daily.

      The smoke from 10 cigarettes gives 20 mg methanol, the same as from 3 full size fresh tomatoes, or 4 cans of unfresh green beans. ]


      smoke from a pack cigarettes gives 40 mg methanol (wood alcohol), same as from 2 aspartame diet drinks -- becomes formaldehyde inside brain and retina cells via ADH1 enzyme -- WC Monte paradigm: Rich Murray 2013.08.30

      11% of aspartame is methanol, which becomes free floating formaldehyde inside human cells -- methanol also in cigarettes and canned fruits and vegetables: Rich Murray 2013.08.30


      Human epidemiological studies so far fail to control for additional common methanol sources: cigarettes and wood and peat smoke, smoked foods, fresh tomatoes, and degraded pectins from unfresh fruits juices vegetables preserved wet at room temperature in sealed cans jars plastic containers...


      autism as a birth defect from epigenetic methylation by formaldehyde made from methanol by ADH1 enzyme inside Purkinje cells in vermis in cerebellum and in inner walls of brain blood vessels -- Prof. WC Monte paradigm: Rich Murray 2013.04.26


      CA Pardo autism brain autopsy findings in 2005 fit WC Monte paradigm -- methanol with blood half-life 3 hours is made by ADH1 enzyme into free floating formaldehyde in 20 defenseless human cells in 20 tissues: Rich Murray 2013.07.21


      The Woodrow C. Monte methanol/formaldehyde toxicity paradigm is that concentrations of ADH1 enzyme, well known to exist inside blood vessel wall cells in specific tissues, quickly turn methanol into formaldehyde inside the vessel cells, in humans only -- the highly reactive formaldehyde diffuses to penetrate adjacent tissue cells, binding to DNA, RNA, and proteins, attracting macrophages, which die, creating complex, expanding micro lesions, leading to many modern "diseases of civilization", Alzheimer's, arthritis, diabetes, multiple sclerosis, lupus -- as well as later cancers -- also serious birth defects in the fetal brain in the fourth week of pregnancy, spinal bifida and autism.

      Aspartame is 11% methanol, 22 mg per can of diet drink -- similar levels of methanol come from wood and cigarette smoke, heated and canned fruits juices vegetables, fermented and smoked foods, some wines and liquors, vehicle fuels, many cleaners and solvents, chemical medical autopsy mortuary facilities, heated wood in particleboard and paper factories, and more.

      WC Monte submits robust evidence for multiple sclerosis, which he concludes proves methanol to be the proximate toxic cause, since ADH1 enzyme is within the cells of the inner linings of brain blood vessels, the Purkinje cells of the vermis of the cerebellum, and rods and cones of the retina -- ADH1 quickly turns methanol into free floating formaldehyde within these cells, disrupting the blood brain barrier...


      See also:

      James McDonald to EFSA, outdated aspartame ADI gives methanol 35 times too high for human safety, ten minute talk at April 9 public sharing, Brussels: Rich Murray 2013.04.15


      aspartame harm in rat brain from 75 mg/kg gives human ADI 0.75 mg/kg, 53 times less than EU ADI 40 mg/kg, Ashok Iyyaswamy, SheelaDevi Rathinasamy, U. Madras 2012.08.03 free full text -- main methanol toxin is formaldehyde, not formate: Rich Murray 2013.06.01


      more lower aspartame and methanol ADIs from studies by RH Nair, SheelaDevi Rathinasamy, WC Monte, PS Jeganathan, A Namasivayam, Hazleton Labs, Searle Labs: Rich Murray 2013.06.01


      Kate S. Collison et al show prediabetic harm in gene expression in mice fed lifetime aspartame, MSG, trans fats -- reduce human aspartame ADI 1000 times: Rich Murray 2013.07.30


      aspartame impairment of spatial cognition and insulin sensitivity in mice, focus on phenylalanine and aspartate [ methanol also crosses placenta into fetus, turning into teratogenic formaldehyde], Kate S. Collison et al, PLoS One 2012.04.03: Rich Murray 2012.04.29


      usual doses of aspartame proven to cause cancers, Michael F. Jacobson PhD, Director, Center for Science in the Public Interest -- also long 1985 statement: Rich Murray 2013.08.15


      highly competent, pithy analysis of aspartame cancer study by Eva S. Schernhammer at Harvard, William R. Ware, PhD, showing relevance of Woodrow C. Monte methanol-formaldehyde toxicity paradigm: Rich Murray 2012.12.03


      careful expert lifetime study on mice shows liver and lung cancers from aspartame, M Soffritti et al, Ramazzini Institute, Italy, checked by US National Toxicology Program experts, confirms many previous studies from 2001 on: Rich Murray 2011.02.27



      The public EFSA session on aspartame safety on April 9 for 5 hours included an audience of about 50 experts and 10-20 ESFA staff in Brussels.
      The release of the final EFSA review on aspartame safety will be delayed from April 15 to early December, 2013.
      Extremely cogent multiple lines of robust evidence were briefly described that strongly support the methanol formaldehyde toxicity paradigm of Prof. Woodrow C. Monte, Prof. Food Science and Nutrition, Arizona State University, retired 2004 -- supported by an online archive of 782 free full text medical research references at     www.WhileScienceSleeps.com .

      It is clear that methanol is far more dangerous for chronic low level exposures than realized since 1890.

      Major sources include the smoke from a pack of cigarettes, 40 mg methanol,the same as from 2 cans aspartame diet drink. It now seems likely that most cigarette diseases are actually methanol toxicity...

      Methanol stays in the blood with a half-life of 3 hours, reaching every part of the body and the fetus with the bloodstream, and readily entering all cells.

      Humans are uniquely vulnerable to methanol formaldehyde toxicity, as they lack a functioning catalase enzyme system, that in all other creatures serves to protect each cell against the rapid conversion of methanol into free floating formaldehyde right inside the cells of 20 specific tissues that have high levels of ADH1 enzyme.
      The effects are used to good advantage in embalming and disinfection, as formaldehyde immediately bonds to and impairs DNA, RNA, and proteins, permanently disrupting cell biochemistry, cell by cell, as long as methanol is ingested -- leading to 20 specific chronic modern novel "diseases of civilization", that progress slowly and erratically, according to the ingestion of methanol from a variety of modern sources:

      smoke from cigarettes, wood, and peat;

      since 1983, aspartame, including from most chewing gums;

      fresh tomatoes and black currants;

      unfresh fruits juices vegetables cut up and preserved wet at room temperature in sealed cans jars plastic containers;

      jams jellies marmalades;

      smoked fermented spoiled foods;

      many dark wines and liquors;

      work at paper and wood factories, mortuaries, medical and chemical facilities;


      Research since 2012 specifically shows the presence of formaldehyde bonded to cellular macromolecules inside cells after methanol ingestion -- the paradigm will be confirmed in detail very quickly, as science exponentially explores this simple breakthrough.

      This presents the world food industry with an unprecedented opportunity to serve the huge public good by collaborating vigorously to eliminate all methanol exposures from foods and beverages. The Net guarantees that the news and evidence will spread explosively everywhere.


      Paul Thomas MD Pediatrics and Integrative Medicine, Portland OR, praises "While Science Sleeps" at Amazon.com -- WC Monte paradigm of methanol formaldehyde toxicity via ADH1 enzyme in 20 human tissues, including fetus: Rich Murray 2013.04.03


      Prof. Resia Pretorius letter re aspartame to EJCN cites Prof. Woodrow C. Monte "While Science Sleeps" text, re methanol/formaldehyde toxicity paradigm: Rich Murray 2012.05.21


      Aspartame: The hidden danger [methanol/formaldehyde] in our midst and how it kills us, 12 page review of While Science Sleeps text (Woodrow C Monte), International Health News, whole June issue, Editor: William R Ware PhD: Rich Murray 2012.06.08


      Table 5.2 is the key chart -- ADH1 enzyme at high levels in 20 tissues in body and fetus makes methanol into formaldehyde right inside cells, initiating over 20 human diseases, with full text references, WC Monte paradigm: Rich Murray 2013.03.21


      "As a matter of course, every soul citizen of Earth has a priority to quickly find and positively share evidence for healthy and safe food, drink, environment, and society."

      within the fellowship of service,

      Rich Murray
      MA Boston University Graduate School 1967 psychology
      BS MIT 1964 history and physics
      254-A Donax Avenue, Imperial Beach, CA 91932-1918



      Original Investigation   February 2014

      Added Sugar Intake and Cardiovascular Diseases Mortality Among US Adults 
      JAMA Intern Med. Published online February 03, 2014. doi:10.1001/jamainternmed.2013.13563

      ONLINE FIRST

      Quanhe Yang, PhD 1;  <qay0@...>,
      Zefeng Zhang, MD, PhD 1;   <hwv0@...>,
      Edward W. Gregg, PhD 2; <edg7@...>,
      W. Dana Flanders, MD, ScD 3; <wflande@...>,
      Robert Merritt, MA 1;  <rem2@...>,
      Frank B. Hu, MD, PhD 4,5

      [-] Author Affiliations

      1 Division for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 
      2 Division of Diabetes Control, Centers for Disease Control and Prevention, Atlanta, Georgia 
      3 Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 
      4 Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 
      5 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 









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