histological and genetic harm of oral aspartame in female rats and pups, Azza A. M. Abd Elfatah, Inas S. Ghaly, Safaa M. Hanafy, Al-Azhar University, Cairo, Pak J Biol Sci. 2012.10.01,15 pages free full text, color microphotos: Rich Murray 2013.12.09
- histological and genetic harm of oral aspartame in female rats and pups,
Azza A. M. Abd Elfatah, Inas S. Ghaly, Safaa M. Hanafy, Al-Azhar
Pak J Biol Sci. 2012.10.01,15 pages free full text, color microphotos: Rich
This matter of fact report details painstaking research that confirms
similar findings by many teams.
They mention the possibility of methanol and formaldehyde toxicity.
[ UK COT chronic methanol toxicity in diet, 2011 July, free full text 22
pages -- earnest critical comments, applying the WC Monte methanol
formaldehyde ADH1 enzyme paradigm: Rich Murray2013.12.09
"As a matter of course, every soul citizen of Earth has a priority to
quickly find and positively share evidence for healthy and safe food,
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MA Boston University Graduate School 1967 psychology
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Pak J Biol Sci. 2012 Oct 1;15(19):904-18.
Cytotoxic effect of aspartame (diet sweet) on the histological and genetic
structures of female albino rats and their offspring.
Abd Elfatah AA, Azza A. M. Abd Elfatah,
Ghaly IS, Inas S. Ghaly,
Hanafy SM. Safaa M. Hanafy.
Department of Anatomy and Embryology,
Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
The present study evaluated the effect of aspartame intake on the
histological and genetic structures of mother albino rats and their
Sixty adult female albino rats and 180 of their offspring were equally
divided into two groups (control and treated), each group divided into
Each subgroup consisted of 10 pregnant rats and 30 of their offspring.
The experimental design divided into three periods:
(1) the gestation period (subgroup one),
(2) the gestation period and three weeks after delivery (subgroup two)
and (3) animals in the third subgroup treated as subgroup two then left
till the end of the ninth week after delivery.
Each pregnant rat in the treated subgroups was given a single daily dose
of 1 mL aspartame solution (50.4 mg) by gastric gavage throughout the time
intervals of experimental design.
At the end of each experimental period for control and treated subgroups,
the liver of half of both control and treated groups were subjected for
histological study while the liver and bone marrow of the other halves were
subjected for cytogenetic studies.
Body weight of both groups were recorded individually twice weekly in the
morning before offering the diet.
The results revealed that the rats and their offspring in the subgroups of
control animals showed increases in body weight, normal histological
sections, low chromosomal aberration and low DNA fragmentation.
The treated animals in the three subgroups rats and their offspring
revealed decreases in body weight, high histological lesions, increases in
the chromosomal aberration and DNA fragmentation compared with control
In conclusion, the consumption of aspartame leads to histopathological
lesions in the liver and alterations of the genetic system in the liver and
bone marrow of mother albino rats and their offspring.
These toxicological changes were directly proportional to the duration of
its administration and improved after its withdrawal.
free full text
15 pages, color microphotos of tissues
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[ past co-author ]
Sahar Ahmed, Department of Cell Biology,
Division of Genetic Engineering and Biotechnology,
National Research Center,
El Buhouth Street, Dokki, Cairo 12311, Egypt;
Sahar Ahmed <selnahta@...<https://mail.google.com/mail/?view=cm&fs=1&tf=1&to=selnahta@...>
>,[ past co-author ]
Mosaad A. Abdel-Wahhab
Toxicology & Contaminants Department, National Research Center, Dokki,
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