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histological and genetic harm of oral aspartame in female rats and pups, Azza A. M. Abd Elfatah, Inas S. Ghaly, Safaa M. Hanafy, Al-Azhar University, Cairo, Pak J Biol Sci. 2012.10.01,15 pages free full text, color microphotos: Rich Murray 2013.12.09

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  • Rich Murray
    histological and genetic harm of oral aspartame in female rats and pups, Azza A. M. Abd Elfatah, Inas S. Ghaly, Safaa M. Hanafy, Al-Azhar University, Cairo,
    Message 1 of 1 , Dec 9, 2013
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      histological and genetic harm of oral aspartame in female rats and pups,
      Azza A. M. Abd Elfatah, Inas S. Ghaly, Safaa M. Hanafy, Al-Azhar
      University, Cairo,
      Pak J Biol Sci. 2012.10.01,15 pages free full text, color microphotos: Rich
      Murray 2013.12.09
      http://rmforall.blogspot.com/2013/12/histological-and-genetic-harm-of-oral.html



      This matter of fact report details painstaking research that confirms
      similar findings by many teams.

      They mention the possibility of methanol and formaldehyde toxicity.

      [ UK COT chronic methanol toxicity in diet, 2011 July, free full text 22
      pages -- earnest critical comments, applying the WC Monte methanol
      formaldehyde ADH1 enzyme paradigm: Rich Murray2013.12.09
      http://rmforall.blogspot.com/2013/12/uk-cot-chronic-methanol-toxicity-in.html

      "As a matter of course, every soul citizen of Earth has a priority to
      quickly find and positively share evidence for healthy and safe food,
      drink, environment, and society."

      within the fellowship of service,

      Rich Murray
      MA Boston University Graduate School 1967 psychology
      BS MIT 1964 history and physics
      254-A Donax Avenue, Imperial Beach, CA 91932-1918
      rmforall@...<https://mail.google.com/mail/?view=cm&fs=1&tf=1&to=rmforall@...>
      505-819-7388 cell
      619-623-3468 home
      http://rmforall.blogspot.com ]


      Pak J Biol Sci. 2012 Oct 1;15(19):904-18.
      Cytotoxic effect of aspartame (diet sweet) on the histological and genetic
      structures of female albino rats and their offspring.
      Abd Elfatah AA, Azza A. M. Abd Elfatah,
      Ghaly IS, Inas S. Ghaly,
      Hanafy SM. Safaa M. Hanafy.
      Department of Anatomy and Embryology,
      Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

      Abstract

      The present study evaluated the effect of aspartame intake on the
      histological and genetic structures of mother albino rats and their
      offspring.

      Sixty adult female albino rats and 180 of their offspring were equally
      divided into two groups (control and treated), each group divided into
      three subgroups.

      Each subgroup consisted of 10 pregnant rats and 30 of their offspring.

      The experimental design divided into three periods:
      (1) the gestation period (subgroup one),
      (2) the gestation period and three weeks after delivery (subgroup two)
      and (3) animals in the third subgroup treated as subgroup two then left
      till the end of the ninth week after delivery.

      Each pregnant rat in the treated subgroups was given a single daily dose
      of 1 mL aspartame solution (50.4 mg) by gastric gavage throughout the time
      intervals of experimental design.

      At the end of each experimental period for control and treated subgroups,
      the liver of half of both control and treated groups were subjected for
      histological study while the liver and bone marrow of the other halves were
      subjected for cytogenetic studies.

      Body weight of both groups were recorded individually twice weekly in the
      morning before offering the diet.

      The results revealed that the rats and their offspring in the subgroups of
      control animals showed increases in body weight, normal histological
      sections, low chromosomal aberration and low DNA fragmentation.

      The treated animals in the three subgroups rats and their offspring
      revealed decreases in body weight, high histological lesions, increases in
      the chromosomal aberration and DNA fragmentation compared with control
      groups.

      In conclusion, the consumption of aspartame leads to histopathological
      lesions in the liver and alterations of the genetic system in the liver and
      bone marrow of mother albino rats and their offspring.

      These toxicological changes were directly proportional to the duration of
      its administration and improved after its withdrawal.

      PMID: 24159687


      http://docsdrive.com/pdfs/ansinet/pjbs/2012/904-918.pdf
      free full text

      15 pages, color microphotos of tissues


      [image: Inline image 4]


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      [image: Inline image 10]
      [ past co-author ]
      Sahar Ahmed, Department of Cell Biology,
      Division of Genetic Engineering and Biotechnology,
      National Research Center,
      El Buhouth Street, Dokki, Cairo 12311, Egypt;
      Fax: +202�33370931;
      Sahar Ahmed <selnahta@...<https://mail.google.com/mail/?view=cm&fs=1&tf=1&to=selnahta@...>
      >,

      [ past co-author ]
      Mosaad A. Abdel-Wahhab
      <mosaad_attia@...<https://mail.google.com/mail/?view=cm&fs=1&tf=1&to=mosaad_attia@...>>,
      Food
      Toxicology & Contaminants Department, National Research Center, Dokki,
      Cairo, Egypt


      [image: Inline image 6]


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