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aspartame water in rats for 6 months causes liver harm, RH Nair et al, Mahatma Gandhi U, Food Chem Toxicol 2011.03.02: Rich Murray 2011.03.12

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  • Rich Murray
    aspartame water in rats for 6 months causes liver harm, RH Nair et al, Mahatma Gandhi U, Food Chem Toxicol 2011.03.02: Rich Murray 2011.03.12
    Message 1 of 1 , Mar 11, 2011
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      aspartame water in rats for 6 months causes liver harm, RH Nair et al,
      Mahatma Gandhi U, Food Chem Toxicol 2011.03.02: Rich Murray 2011.03.12
      http://rmforall.blogspot.com/2011_03_01_archive.htm
      Saturday, March 12, 2011
      [ at end of each long page, click on Older Posts ]
      http://groups.yahoo.com/group/aspartameNM/message/1620
      [you may have to Copy and Paste URLs into your browser]


      http://www.ncbi.nlm.nih.gov/pubmed/21376768

      Food Chem Toxicol. 2011 Mar 2. [Epub ahead of print]
      Effect of long term intake of aspartame on antioxidant defense status in liver.
      Abhilash M, Paul MV, Varghese MV, Nair RH.
      School of Biosciences, Mahatma Gandhi University,
      Kottayam, Kerala, India, 686560.
      harikumarannair@..., harinair@...,

      Abstract

      The present study evaluates the effect of long term intake of
      aspartame, the artificial sweetener, on liver antioxidant system and
      hepatocellular injury in animal model.
      Eighteen adult male Wistar rats, weighing 150 - 175 g, were randomly
      divided into three groups as follows:
      first group was given aspartame dissolved in water in a dose of 500 mg/kg.b.wt;
      the second group was given a dose of 1000 mg/kg.b.wt;
      and controls were given water freely.
      Rats that had received aspartame (1000 mg/kg.b.wt) in the drinking
      water for 180 days showed a significant increase in activities of
      alanine aminotransferase (ALT),
      aspartate aminotransferase (AST),
      alkaline phosphatase (ALP) and
      y-glutamyl transferase (GGT).
      The concentration of reduced glutathione (GSH)
      and the activity of glutathione peroxidase (GPx), and
      glutathione reductase (GR)
      were significantly reduced in the liver of rats that had received
      aspartame (1000 mg/kg.b.wt).
      Glutathione was significantly decreased in both the experimental groups.
      Histopathological examination revealed leukocyte infiltration in
      aspartame-treated rats (1000 mg/kg.b.wt).
      It can be concluded from these observations that long term consumption
      of aspartame leads to hepatocellular injury and alterations in liver
      antioxidant status mainly through glutathione dependent system.
      Copyright 2011. Published by Elsevier Ltd. PMID: 21376768

      Souganth Paul, MV - Research Fellow

      Abhilash, M - Research Fellow

      Mathews V Varghese - Research Fellow

      http://www.mgu.ac.in/index.php?option=com_content&view=article&id=493&Itemid=96

      School of Bio-Sciences Teacher Profiles [photo]

      Name: Dr. R. Harikumaran Nair
      Designation: Assistant Professor
      Address: Room No. 5
      School of Biosciences,
      Mahatma Gandhi University
      Priyadarshini Hills. P O., Kottayam-686 560
      Kerala, India
      Phone: +91-481-2731035 Extension: 16
      Mobile Phone: +91-94472 60362
      Email: harikumarannair@..., harinair@...
      Home page: www.biophysiol.org

      Research Interest

      In our laboratory, we study the effect of food additives such as
      monosodium glutamate, aspartame, drug component arsenic trioxide and
      other toxins like organic solvents on different physiological
      mechanisms in rats and tissue culture model systems.
      Another area of interest is environmental and occupational stress.

      Academic Profile

      Ph. D - Physiology (2001), School of Biosciences,
      Mahatma Gandhi University, Kottayam, Kerala, India
      M. Sc - Zoology (1994)
      University of Kerala, Thiruvananthapuram, Kerala, India,
      B. Sc - Zoology (1992)
      University of Kerala, Thiruvananthapuram, Kerala, India,

      Professional Experience:

      *Lecturer in Physiology (Permanent service) -
      School of Biosciences, Mahatma Gandhi
      University, Kerala, India. 22nd May 2006 to present
      *Lecturer in Physiology (contract service) -
      School of Biosciences, Mahatma Gandhi University, Kerala, India. 20th
      November 2003 to 21st May 2006
      *Postdoctoral Research fellow -
      Dept. of Physiology, St. John's Medical College, Bangalore, India.
      01st March 2002 to 15th July 2002
      *Research Fellow -
      School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala,
      India. October 1995 to April 2001

      Group Members

      Sagi, TM - Research Fellow
      Souganth Paul, MV - Research Fellow
      Abhilash, M - Research Fellow
      Mathews V Varghese - Research Fellow
      Manju Alex - Research Fellow

      Publications:

      Scientific Proceedings

      1. Abhilash M, Shashidhar S, Harikumaran Nair R,
      The role of electrolytes in cataractogenesis and modulation by silver
      nitrate in albino rats.
      22nd Kerala Science Congress. 28-31 January 2010. KFRI, Peechi,
      Thrissur, Kerala, India

      2. Sauganth Paul, Harikumaran Nair R, Shashidhar S,
      Lipid peroxidation and antioxidant activities in hypertensive subjects
      of different age groups.
      Indian Science Congress, Medical Sciences section. 03.01.2010 to 07.01.2010,
      University of Kerala, Kerala, India

      Publications

      1. Ajitha Kumari R, Shashidhar S and Harikumaran Nair R,
      Oxidative stress and lung functions in diabetic mellitus.
      Biomedicine. 2010 (accepted)

      2. Pankajam K, Harikumaran Nair R, Kesavachandran C, Rethamma KV, and
      Shashidhar S,
      Effects of Automobile exhaust pollution on the pulmonary functions in
      shopkeepers.
      Pollution Research. 2005; 24(1): 51-56.

      3. Kesavachandran C, Harikumaran Nair R. and Shashidhar S.
      Pulmonary function studies in Kalarypayathu Practitioners.
      Ind. J. Physiol. Pharmacol., 2004; 48(2), 235-240.

      4. Geetha B., Harikumaran Nair R, Kesavachandran C, Susan Chandy and
      Shashidhar S,
      Pulmonary functions in workers of fertilizer and chemical Industry.
      Ind.J.Physiol.Pharmacol. 2001; 45(2):215-221.

      5. Geetha B., Harikumaran Nair R, Kesavachandran, C and Shashidhar S,
      Respiratory Function Studies in Rare Earth Factory Workers.
      Pollution Research 2001; 20(1):115-119.

      6. Kesavachandran C, Harikumaran Nair R, and Shashidhar S,
      Lung Volume in Swimmers performing different strokes.
      Ind.J.Med.Sci. 2001; 55(12):669-676.

      7. Reethamma KV, Harikumaran Nair R, Kesavachandran C and Shashidhar S,
      Effect of Wood Dust on Lung Functions.
      Pollution Research 2000; 19(4):693-699.

      8. Harikumaran Nair R, Kesavachandran C and Shashidhar S,
      Spirometric Impairments in Undernourished Children.
      Ind.J.Physiol.Pharmacol.1999; 43(4):467-473.

      9. Harikumaran Nair R, Kesavachandran C, Sanil R, Sreekumar R and Shashidhar S,
      Prediction Equation for Lung Functions in South Indian Children.
      Ind.J.Physiol.Pharmacol.1997; 41(4):390-396.

      10. Kesavachandran C., Sanil R, Harikumaran Nair R, Arun A Rauf and
      Shashidhar S,
      Pulmonary Function Studies in Rowers.
      Ind.J.Physiol.Pharmacol.1997; 41(1):29-34.

      11. Bindu K Pazhur, Susan Chandy, Harikumaran Nair R, and Shadhidhar S,
      Effect of Domestic Cooking Fuels on Lung Function in Women.
      Pollution Research 1997;16(3):149-154.

      Scientific Papers in International Conference:

      1. Geetha B, Harikumaran Nair R, Kesavachandran C and Shashidhar S,
      Respiratory Function Studies on Newsprint Factory workers.
      International Conference on Health, Occupation and Environment in
      Unorganized Sector - Problems and Road Maps (ICHOE 2004). November
      1-3, 2004, Industrial Toxicology Research Centre (ITRC, CSIR),
      Lucknow, INDIA.

      2. Rethamma KV, Harikumaran Nair R, Kesavachandran C and Shashidhar S,
      Pulmonary function status among Wood workers.
      International Conference on Health, Occupation and Environment in
      Unorganized Sector - Problems and Road Maps (ICHOE 2004). November
      1-3, 2004, Industrial Toxicology Research Centre
      (ITRC, CSIR), Lucknow, INDIA.

      Academic & Administrative Duties

      * Chairman, B Sc Biophysics Board of Examinations,
      University of Calicut, Kerala, India
      * Convenor & Member, Institutional Animal Ethics Committee,
      Mahatma Gandhi University, Kerala, India
      * Member Secretary, Institutional Human Ethics Committee,
      Mahatma Gandhi University, Kerala, India
      * External Examiner in Fundamentals of Physiology,
      School of Medical Education,
      Mahatma Gandhi University, Kerala, India
      * Member, Campus Development Committee,
      Mahatma Gandhi University, Kerala, India

      Training undertaken: ( 2007 Onwards)

      * Refresher Course in Lifesciences. 08.12.2009 to 29.12.2009
      UGC Academic Staff College, University of Kerala, Kerala
      * University workshop on Research Projects, 02.04.2009
      Mahatma Gandhi University, Kerala
      * UGC sponsored short term course for Research Guides. 23.03.2009 to
      28.03.2009
      UGC Academic Staff College, University of Kerala, Kerala.
      * Workshop on Curriculum Design for B.Sc. Biophysics Course,
      Kerala State Higher Education Council and
      the University of Calicut, Kerala, 24.02.2009 to 28.02.2009

      Research Collaborations
      IITR - Lucknow,UP, India
      NIIST - Thiruvananthapuram, Kerala, India

      Copyright 2010 MG University, All Rights Reserved. Content by PRD.
      Supported by System Administration Team, M.G. University
      _______________________________________________


      careful expert lifetime study on mice shows liver and lung cancers
      from aspartame, M Soffritti et al, Ramazzini Institute, Italy, checked
      by US National Toxicology Program experts, confirms many previous
      studies from 2001 on: Rich Murray 2011.02.27
      http://rmforall.blogspot.com/2011_02_01_archive.htm
      Sunday, February 27, 2011
      [ at end of each long page, click on Older Posts ]
      http://groups.yahoo.com/group/aspartameNM/message/1619
      [you may have to Copy and Paste URLs into your browser]

      re GC Ebers study, females harmed more by body making methanol into
      formaldehyde in brain via ADH enzyme: 589 references, WC Monte,
      retired Prof. Nutrition: Rich Murray 2011.01.08
      http://rmforall.blogspot.com/2011_01_01_archive.htm
      Saturday, January 8, 2011
      [ at end of each long page, click on Older Posts ]
      http://groups.yahoo.com/group/aspartameNM/message/1614
      [you may have to Copy and Paste URLs into your browser]

      Woodrow C Monte, PhD, Emiritus Prof. Nutrition gives many PDFs of
      reseach -- methanol (11% of aspartame) puts formaldehyde into brain
      and body -- multiple sclerosis, Alzheimer's, cancers, birth defects,
      headaches: Rich Murray 2010.05.13
      http://rmforall.blogspot.com/2010_05_01_archive.htm
      Thursday, May 13, 2010
      http://groups.yahoo.com/group/aspartameNM/message/1601

      [ Other formaldehyde sources include alcohol drinks and
      tobacco and wood smoke,
      while adequate folic acid levels protect most people. ]

      http://whilesciencesleeps.com/about

      http://while-science-sleeps.com/references/pdf/586
      [ summary, not peer reviewed ]
      Monte WC.
      Methanol: A chemical Trojan horse as the root of the inscrutable U.
      Medical Hypotheses 2010;74(3):493-6
      DOI 2010.10.16

      Monte WC.
      Bittersweet: Aspartame Breast Cancer Link.
      Fitness Life 2008 Jan. 34: 32-36

      Monte WC.
      A Deadly Experiment. Methanol and MS,
      Fitness Life 2007 Dec. 34: 36-41

      Monte WC.
      Sickly Sweet: Is your Diet Sweetener killing you?
      Fitness Life 2007 Nov. 33: 31-33

      http://whilesciencesleeps.com/references
      589 references for above articles and upcoming book

      http://whilesciencesleeps.com/montediet
      [ and Fitness Life 2007 Dec. 34: 36-41 ]

      Methanol: Where Is It Found? How Can It Be Avoided?

      AVOID the following, ranked in order of greatest danger:

      1. Cigarettes.
      2. Diet foods and drinks with aspartame.
      3. Fruit and vegetable products and their juices in bottles,
      cans, or pouches.
      4. Jellies, jams, and marmalades not made fresh and kept
      refrigerated.
      5. Black currant and tomato juice products, fresh or
      processed.
      6. Tomato sauces, unless first simmered at least 3 hours
      with an open lid.
      7. Smoked food of any kind, particularly fish and meat.
      8. Sugar-free chewing gum.
      9. Slivovitz: You can consume one alcoholic drink a day
      on this diet -- no more! [ no fruit brandies ]
      10. Overly ripe or near rotting fruits or vegetables.

      Selection from Article 2, Fitness Life, December 2007, and
      well discussed in the DVD video:

      "Identical Symptoms of MS, Methanol Poisoning
      and Aspartame Toxicity

      The symptoms of multiple sclerosis (44, 83, 85, 169), chronic
      and acute methanol poisoning (13, 144, 189), and Aspartame
      toxicity (54, 58, 93, 181), are in all ways identical.

      There is nothing that happens to the human body from the
      toxic effect of methanol that has not been expressed during
      the course of MS... nothing (143, 144).

      This generalization extends even to the remarkable
      opthomological conditions common to both: transitory optic
      neuritis and retrolaminar demyelinating optic neuropathy with
      scotoma of the central visual field (which occasionally
      manifests as unilateral temporary blindness (85, 138, 163).

      In fact, these opthomological symptoms have been thought of
      for years in their respective literatures to be "tell tale"
      indications for the differential diagnosis for each of these
      maladies independently (85, 138, 148, 163, 169).

      The common symptoms of
      headache (13, 83, 181, 189),
      nervousness (13, 83, 181),
      depression (58, 83, 189, 181),
      memory loss (18, 147, 85, 169, 181),
      tingling sensations (13, 85, 168, 138, 169),
      pain in the extremities (13, 85, 169),
      optic neuritis (85, 138, 148, 163, 169),
      bright lights in the visual field (139, 83),
      seizures (21, 83, 160),
      inability to urinate or to keep from urinating (139, 146, 167)
      are all shared by each of these conditions and shared yet
      again by complaints from aspartame poisoning
      (54, 58, 93, 181).

      I take these strikingly similar symptom patterns as evidence
      that these disorders act on identical components of the
      central nervous system and in the same way.

      The "Miracle" that MS shares with Methanol poisoning

      In the early stages of MS, or when a non-lethal dose of
      methanol has been administered, complete recovery is a
      possibility.

      The only two afflictions for which such dramatic "remissions"
      are reported from identical neuromuscular and opthomological
      damage, even "blindness" is relapsing-remitting multiple
      sclerosis (85) and methyl alcohol poisoning (138, 163).

      The pathology of the two maladies is in may ways identical,
      particularly when it comes to destruction of the myelin
      sheath with no harm to the axon itself (18, 148, 176).

      Sex Ratios for MS and Aspartame Reactions

      Women bear the brunt of multiple sclerosis (91a-c) and lupus
      (SLE)(73) with fully three-fold representations in infliction
      numbers over men for both diseases.

      This is exactly the proportion represented by adverse
      reactors to Aspartame reported by the US Center for
      Disease Control in their study of 1984 (58).

      The Center found three women to every man whose
      Aspartame consumption complaints were serious enough
      to warrant investigation (93).

      Although the female/male ratio for those stricken with MS has
      always been high, recent estimates place it at over 3 to 1
      (91, 91a, 91c).

      What might account for the difference across sexes in
      incidence?

      A study published in the New England Journal of Medicine
      (94) reports biopsies of the gastric lining of men and women.

      A result was that the concentration of ADH in the
      gastric lining of men was much higher than for woman.

      Men have the advantage of removing methanol from the
      bloodstream four times faster on an equal-body-size basis
      than women.

      Thus, for men, methanol is more likely to be removed from the
      blood before it reaches the brain.

      The brain is spared but the methanol removed would still be
      metabolized to formaldehyde in the gut where it would reap
      its havoc on a more forgiving organ.

      This may help explain why men have more gastrointestinal
      complaints from both methanol and Aspartame consumption
      (93, 99).

      On the other hand, women's complaints from both more
      frequently involve serious neurological complications."...
      ______________________________________________


      methanol (11% of aspartame), made by body into
      formaldehyde in many vulnerable tissues, causes modern
      diseases of civilization, summary of a century of research,
      Woodrow C Monte PhD, Medical Hypotheses journal:
      Rich Murray 2009.11.15
      http://rmforall.blogspot.com/2009_11_01_archive.htm
      Sunday, November 15, 2009
      [ at end of each long page, click on Older Posts ]
      http://groups.yahoo.com/group/aspartameNM/message/1589
      [you may have to Copy and Paste URLs into your browser]

      aspartame abstinance cures fibromyalgia chronic pain in 2 French
      adults: R Ciappuccini et al, Clin Exp Rheumatol 2010 Nov: Rich Murray
      2010.02.19
      http://rmforall.blogspot.com/2011_02_01_archive.htm
      Saturday, February 19, 2011
      [ at end of each long page, click on Older Posts ]
      http://groups.yahoo.com/group/aspartameNM/message/1617
      [you may have to Copy and Paste URLs into your browser]

      formaldehyde from 0.2 mg daily methanol from aspartame in Singulair
      (montelukast) chewable asthma medicine causes severe allergic
      dermatitis in boy, SE Jacob et al, Pediatric Dermatology 2009 Nov:
      Rich Murray 2010.09.27
      http://rmforall.blogspot.com/2010_09_01_archive.htm
      Monday, September 27, 2010
      [ at end of each long page, click on Older Posts ]
      http://groups.yahoo.com/group/aspartameNM/message/1613
      [you may have to Copy and Paste URLs into your browser]
      ______________________________________________

      Rich Murray, MA
      Boston University Graduate School 1967 psychology,
      BS MIT 1964, history and physics,
      1943 Otowi Road, Santa Fe, New Mexico 87505
      505-819-7388 rmforall@...

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