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aspartame abstinance cures fibromyalgia chronic pain in 2 French adults: R Ciappuccini et al, Clin Exp Rheumatol 2010 Nov: Rich Murray 2011.02.19

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  • Rich Murray
    aspartame abstinance cures fibromyalgia chronic pain in 2 French adults: R Ciappuccini et al, Clin Exp Rheumatol 2010 Nov: Rich Murray 2011.02.19
    Message 1 of 1 , Feb 19 10:29 PM
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      aspartame abstinance cures fibromyalgia chronic pain in 2 French
      adults: R Ciappuccini et al, Clin Exp Rheumatol 2010 Nov: Rich Murray
      Saturday, February 19, 2011
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      Clin Exp Rheumatol. 2010 Nov-Dec;28(6 Suppl 63):S131-3. Epub 2010 Dec 22.
      Aspartame-induced fibromyalgia, an unusual but curable cause of chronic pain.
      Ciappuccini R,
      Ansemant T,
      Maillefert JF, <jean-francis.maillefert@...>,
      Tavernier C,
      Ornetti P. <paul.ornetti@...>,
      Department of Rheumatology, Dijon University Hospital,
      Burgundy University, Faculty of Medicine, Dijon, France.


      We report for the first time an unusual musculoskeletal adverse effect
      of aspartame in two patients.
      A 50-year-old woman had been suffering from widespread pain and
      fatigue for more than 10 years leading to the diagnosis of
      During a vacation in a foreign country, she did not suffer from
      painful symptoms since she had forgotten to take her aspartame.
      All of the symptoms reappeared in the days following her return when
      she reintroduced aspartame into her daily diet.
      Thus, aspartame was definitively excluded from her diet, resulting in
      a complete regression of the fibromyalgia symptoms.

      A 43-year-old man consulted for a 3-year history of bilateral forearm,
      wrist, and hand and cervical pain with various unsuccessful
      A detailed questioning allowed to find out that he had been taking
      aspartame for three years.
      The removal of aspartame was followed by a complete regression of
      pain, without recurrence.
      We believe that these patients' chronic pain was due to the ingestion
      of aspartame, a potent flavouring agent, widely used in food as a
      The benefit/ risk ratio of considering the diagnosis of
      aspartame-induced chronic pain is obvious:
      the potential benefit is to cure a disabling chronic disease,
      to spare numerous laboratory and imaging investigations, and
      to avoid potentially harmful therapies;
      the potential risk is to temporarily change the patient's diet.

      Thus, practitioners should ask patients suffering from fibromyalgia
      about their intake of aspartame.
      In some cases, this simple question might lead to the resolution of a
      disabling chronic disease.
      PMID: 21176433

      Paris aspartame conference 16 p in French 2011.01.21: Rich Murray 2011.01.22
      Saturday, January 22, 2011
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      16 p in French 2011.01.21


      Pauline Berthellemy pberthellemy.res@...
      06 11 41 13 54

      Soleane Duplan res.contact@...
      06 70 07 84 87
      09 54 05 24 11

      Dr. Laurent Chevallier
      04 67 02 49 04
      Clinique du Parc
      Chemin des Guilhems
      34171 Castelnau Le Lez
      Paris, FR

      Andre Ciolella

      Ann N Y Acad Sci. 2006 Sep;1076:784-9.
      Glycol ethers: a ubiquitous family of toxic chemicals: a plea for
      REACH regulation.
      Cicolella A.
      Health Risk Assessment Unit,
      National Institute of Risks and Industrial Environment, INERIS
      BP N 2, 60550 Verneuil-en-Halatte, France. andre.cicolella@...

      Glycol ethers (GE) are chemicals used since the 1930s as solvents in
      paints, inks, varnishes, and cleaning agents, mainly in water-based
      products, cosmetics, and drugs.
      World production approximates 1 million tons.
      Nineteen GE are produced or imported each year;
      over 1000 tons in European Union (EU) have been classified as high
      production volume chemicals (HPVCs).
      First animal data were published in 1971 and 1979 showing severe
      reprotoxicity for some GE.
      Two alerts were launched in the United States in 1982 and 1983, but
      the first partial GE regulation only occurred in 1993 in the EU.
      Although these chemicals may expose a very large population, basic
      toxicity data, more especially carcinogenicity, are still lacking
      (3/32 GE).
      However, experimental data were sufficient to lead developmental
      toxicity risk assessment since the early 1980s.
      Risk indices over 1000 have been calculated for consumers and workers
      exposed to reprotoxic GE in domestic and industrial activities.
      The first ban was decided in 1999 in France, but was only for drugs
      and cosmetics.
      Not surprisingly, since the late 1980s, human studies have found
      results similar to those in animal data: spontaneous abortions,
      malformations, testicular toxicity, and hematotoxicity.
      Despite this highly coherent set of data, and although substitution
      products are available, reprotoxic GE have been and still remain
      widely used in the world.
      The case of GE shows the failure of the present system based on a
      posteriori risk assessment.
      This pleads for the change of paradigm through the European REACH
      regulation based on the "No data, no market" principle. Ethics in
      REACH management should also be considered.
      PMID: 17119255

      Pierre Meneton pierre.meneton@...

      Physiol Rev. 2005 Apr;85(2):679-715.
      Links between dietary salt intake, renal salt handling, blood
      pressure, and cardiovascular diseases.
      Meneton P, Jeunemaitre X, de Wardener HE, MacGregor GA.
      Institut National de la Santé et de la Recherche Médicale U367,
      Département de Santé Publique et d'Informatique Médicale,
      Faculté de Médecine Broussais Hôtel Dieu, Paris, France. pmeneton@...

      Epidemiological, migration, intervention, and genetic studies in
      humans and animals provide very strong evidence of a causal link
      between high salt intake and high blood pressure.
      The mechanisms by which dietary salt increases arterial pressure are
      not fully understood, but they seem related to the inability of the
      kidneys to excrete large amounts of salt.
      From an evolutionary viewpoint, the human species is adapted to ingest
      and excrete <1 g of salt per day, at least 10 times less than the
      average values currently observed in industrialized and urbanized
      Independent of the rise in blood pressure, dietary salt also increases
      cardiac left ventricular mass, arterial thickness and stiffness, the
      incidence of strokes, and the severity of cardiac failure.
      Thus chronic exposure to a high-salt diet appears to be a major factor
      involved in the frequent occurrence of hypertension and cardiovascular
      diseases in human populations.
      PMID: 1578870



      Francois Veillerette mdrgf@...

      Nadine Lauverjat mdrdf2@...

      news video in French 2010.03.14 4:20 19.72 MB

      Claude Rene Lambre claude.lambre@...
      +33 1 40 56 79 29

      Andre Aschieri

      Woodrow Monte ,
      andre.cicolella@..., pierre.meneton@...,
      pmenetone@..., pberthellemy.res@...,
      res.contact@..., pierre.meneton@..., mdrgf@...,
      mdrgf2@..., claude.lambre@...,

      re GC Ebers study, females harmed more by body making methanol into
      formaldehyde in brain via ADH enzyme: 589 references, WC Monte,
      retired Prof. Nutrition: Rich Murray 2011.01.08
      Saturday, January 8, 2011
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      Woodrow C Monte, PhD, Emiritus Prof. Nutrition gives many PDFs of
      reseach -- methanol (11% of aspartame) puts formaldehyde into brain
      and body -- multiple sclerosis, Alzheimer's, cancers, birth defects,
      headaches: Rich Murray 2010.05.13
      Thursday, May 13, 2010

      [ Other formaldehyde sources include alcohol drinks and
      tobacco and wood smoke,
      while adequate folic acid levels protect most people. ]


      589 references, many abstracts and full texts

      Methanol: Where Is It Found? How Can It Be Avoided?

      AVOID the following, ranked in order of greatest danger:

      1. Cigarettes.
      2. Diet foods and drinks with aspartame.
      3. Fruit and vegetable products and their juices in bottles,
      cans, or pouches.
      4. Jellies, jams, and marmalades not made fresh and kept
      5. Black currant and tomato juice products, fresh or
      6. Tomato sauces, unless first simmered at least 3 hours
      with an open lid.
      7. Smoked food of any kind, particularly fish and meat.
      8. Sugar-free chewing gum.
      9. Slivovitz: You can consume one alcoholic drink a day
      on this diet -- no more! [ no fruit brandies ]
      10. Overly ripe or near rotting fruits or vegetables.

      Selection from Article 2, Fitness Life, December 2007, and
      well discussed in the DVD video:

      "Identical Symptoms of MS, Methanol Poisoning
      and Aspartame Toxicity

      The symptoms of multiple sclerosis (44, 83, 85, 169), chronic
      and acute methanol poisoning (13, 144, 189), and Aspartame
      toxicity (54, 58, 93, 181), are in all ways identical.

      There is nothing that happens to the human body from the
      toxic effect of methanol that has not been expressed during
      the course of MS... nothing (143, 144).

      This generalization extends even to the remarkable
      opthomological conditions common to both: transitory optic
      neuritis and retrolaminar demyelinating optic neuropathy with
      scotoma of the central visual field (which occasionally
      manifests as unilateral temporary blindness (85, 138, 163).

      In fact, these opthomological symptoms have been thought of
      for years in their respective literatures to be "tell tale"
      indications for the differential diagnosis for each of these
      maladies independently (85, 138, 148, 163, 169).

      The common symptoms of
      headache (13, 83, 181, 189),
      nervousness (13, 83, 181),
      depression (58, 83, 189, 181),
      memory loss (18, 147, 85, 169, 181),
      tingling sensations (13, 85, 168, 138, 169),
      pain in the extremities (13, 85, 169),
      optic neuritis (85, 138, 148, 163, 169),
      bright lights in the visual field (139, 83),
      seizures (21, 83, 160),
      inability to urinate or to keep from urinating (139, 146, 167)
      are all shared by each of these conditions and shared yet
      again by complaints from aspartame poisoning
      (54, 58, 93, 181).

      I take these strikingly similar symptom patterns as evidence
      that these disorders act on identical components of the
      central nervous system and in the same way.

      The "Miracle" that MS shares with Methanol poisoning

      In the early stages of MS, or when a non-lethal dose of
      methanol has been administered, complete recovery is a

      The only two afflictions for which such dramatic "remissions"
      are reported from identical neuromuscular and opthomological
      damage, even "blindness" is relapsing-remitting multiple
      sclerosis (85) and methyl alcohol poisoning (138, 163).

      The pathology of the two maladies is in may ways identical,
      particularly when it comes to destruction of the myelin
      sheath with no harm to the axon itself (18, 148, 176).

      Sex Ratios for MS and Aspartame Reactions

      Women bear the brunt of multiple sclerosis (91a-c) and lupus
      (SLE)(73) with fully three-fold representations in infliction
      numbers over men for both diseases.

      This is exactly the proportion represented by adverse
      reactors to Aspartame reported by the US Center for
      Disease Control in their study of 1984 (58).

      The Center found three women to every man whose
      Aspartame consumption complaints were serious enough
      to warrant investigation (93).

      Although the female/male ratio for those stricken with MS has
      always been high, recent estimates place it at over 3 to 1
      (91, 91a, 91c).

      What might account for the difference across sexes in

      A study published in the New England Journal of Medicine
      (94) reports biopsies of the gastric lining of men and women.

      A result was that the concentration of ADH in the
      gastric lining of men was much higher than for woman.

      Men have the advantage of removing methanol from the
      bloodstream four times faster on an equal-body-size basis
      than women.

      Thus, for men, methanol is more likely to be removed from the
      blood before it reaches the brain.

      The brain is spared but the methanol removed would still be
      metabolized to formaldehyde in the gut where it would reap
      its havoc on a more forgiving organ.

      This may help explain why men have more gastrointestinal
      complaints from both methanol and Aspartame consumption
      (93, 99).

      On the other hand, women's complaints from both more
      frequently involve serious neurological complications."...

      methanol (11% of aspartame), made by body into
      formaldehyde in many vulnerable tissues, causes modern
      diseases of civilization, summary of a century of research,
      Woodrow C Monte PhD, Medical Hypotheses journal:
      Rich Murray 2009.11.15
      Sunday, November 15, 2009
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      formaldehyde from 0.2 mg daily methanol from aspartame in Singulair
      (montelukast) chewable asthma medicine causes severe allergic dermatitis in
      boy, SE Jacob et al, Pediatric Dermatology 2009 Nov: Rich Murray 2010.09.27
      Monday, September 27, 2010
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      Rich Murray, MA
      Boston University Graduate School 1967 psychology,
      BS MIT 1964, history and physics,
      1943 Otowi Road, Santa Fe, New Mexico 87505
      505-819-7388 rmforall@...


      http://RMForAll.blogspot.com new primary archive

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