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formaldehyde from 0.2 mg daily methanol from aspartame in Singulair (montelukast) chewable asthma medicine causes severe allergic dermatitis in boy, SE Jacob et al, Pediatric Dermatology 2009 Nov: Rich Murray 2010.09.27

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  • Rich Murray
    formaldehyde from 0.2 mg daily methanol from aspartame in Singulair (montelukast) chewable asthma medicine causes severe allergic dermatitis in boy, SE Jacob
    Message 1 of 1 , Sep 27, 2010
      formaldehyde from 0.2 mg daily methanol from aspartame in Singulair
      (montelukast) chewable asthma medicine causes severe allergic dermatitis in
      boy, SE Jacob et al, Pediatric Dermatology 2009 Nov: Rich Murray 2010.09.27
      Monday, September 27, 2010
      [ at end of each long page, click on Older Posts ]
      [you may have to Copy and Paste URLs into your browser]


      Pediatr Dermatol. 2009 Nov-Dec;26(6):739-43.
      Systematized contact dermatitis and montelukast in an atopic boy.
      Castanedo-Tardan MP,
      González ME,
      Connelly EA,
      Giordano K,
      Jacob SE.
      Mari Paz Castanedo-Tardan
      Mercedes E. González
      Elizabeth A. Connelly
      Kelly Giordano
      Sharon E. Jacob
      University of Miami, Miller School of Medicine,
      Department of Dermatology and Cutaneous Surgery,
      Miami, Florida, USA.
      Article first published online: 2 APR 2009
      DOI: 10.1111/j.1525-1470.2008.00855.x
      © 2009 Wiley Periodicals, Inc.


      Upon ingestion, the artificial sweetener, aspartame is metabolized to
      formaldehyde in the body and has been reportedly associated with systemic
      contact dermatitis in patients exquisitely sensitive to formaldehyde.
      We present a case of a 9-year-old Caucasian boy with a history of mild
      atopic dermatitis that experienced severe systematized dermatitis after
      being started on montelukast chewable tablets containing aspartame.
      Patch testing revealed multiple chemical sensitivities which included a
      positive reaction to formaldehyde.
      Notably, resolution of his systemic dermatitis only occurred with
      discontinuation of the montelukast chewables.
      PMID: 20199453

      We present a case of a 9-year-old Caucasian boy with a history of mild
      atopic dermatitis (stable on topical ta-crolimus ointment 0.03%), mild
      intermittent asthma and known food and environmental allergies diagnosed by
      prick testing (egg, soy, and peanut) at 3 years of age, and wheat ...

      Montelukast Chewable Tablets
      Pronunciation: mon-te-LOO-kast
      Generic Name: Montelukast
      Brand Name: Singulair

      http://www.rxlist.com/singulair-drug.htm 13 pages

      Copyright 1996-2009 Cerner Multum, Inc.
      Version: 7.03. Revision date: 06/25/2009.


      Phenylketonuric patients should be informed that the 4-mg and 5-mg chewable
      tablets contain phenylalanine (a component of aspartame), 0.674 and 0.842 mg
      per 4-mg and 5-mg chewable tablet, respectively.

      [ Since phenylalanine is 50% by weight of aspartame, the dose of aspartame
      is 1.348 mg and 1.684 mg, releasing the very small dose of methanol, 11 %,
      of 0.148 mg and 0.185 mg, of which about 30% remains in the body as
      cumulative durable toxic reaction products, concentrated where the tissues
      have high levels of the ADH enzyme, such as brain, retina, skin, liver,
      kidney, GI tract, and muscle -- the ADH enzyme turns methanol into
      formaldehyde, part of which becomes another toxin, formic acid. ]
      A 12-oz can of diet drink has 200 mg aspartame, releasing 22 mg methanol
      into the body, resulting in about 7 mg retained toxic products of
      formadehyde and formic acid in concentrated locations. ]


      Hypersensitivity to any component of this product.

      Who should not take SINGULAIR?

      Do not take SINGULAIR if you are allergic to any of its ingredients.


      Use of this medication is not recommended in children less than 15 years

      What is Singulair?

      What is the dose of SINGULAIR?

      The dose of SINGULAIR prescribed for your or your child's condition is based
      on age:

      2 to 5 years: one 4-mg chewable tablet
      6 to 14 years: one 5-mg chewable tablet.

      The mean systemic exposure of the 4-mg chewable tablet in pediatric patients
      2 to 5 years of age and the 5-mg chewable tablets in pediatric patients 6 to
      14 years of age is similar to the mean systemic exposure of the 10-mg
      film-coated tablet in adults.

      The 5-mg chewable tablet should be used in pediatric patients 6 to 14 years
      of age
      and the 4-mg chewable tablet should be used in pediatric patients 2 to 5
      years of age.

      Montelukast sodium, the active ingredient in SINGULAIR, is a selective and
      orally active leukotriene receptor antagonist that inhibits the cysteinyl
      leukotriene CysLT1 receptor.

      Each 4-mg and 5-mg chewable SINGULAIR tablet contains 4.2 and 5.2 mg
      montelukast sodium, respectively, which are equivalent to 4 and 5 mg of
      montelukast, respectively.

      Both chewable tablets contain the following inactive ingredients: mannitol,
      microcrystalline cellulose, hydroxypropyl cellulose, red ferric oxide,
      croscarmellose sodium, cherry flavor, aspartame, and magnesium stearate.

      SINGULAIR is indicated for the prophylaxis and chronic treatment of asthma
      in adults and pediatric patients 12 months of age and older.

      Exercise-Induced Bronchoconstriction
      SINGULAIR is indicated for prevention of exercise-induced
      bronchoconstriction (EIB) in patients 15 years of age and older.

      Allergic Rhinitis
      SINGULAIR is indicated for the relief of symptoms of seasonal allergic
      rhinitis in patients 2 years of age and older and perennial allergic
      rhinitis in patients 6 months of age and older.

      four Murray AspartameNM reviews in SE Jacob & SA
      Stechschulte debate with EG Abegaz & RG Bursey of
      Ajinomoto re migraines from formaldehyde from aspartame,
      Dermatitis 2009 May: TE Hugli -- folic acid with V-C
      protects: Rich Murray 2009.08.12
      Wednesday, August 12, 2009
      [ extracts ]

      Formaldehyde, aspartame, migraines: a possible connection.
      Abegaz EG, Bursey RG.
      Dermatitis. 2009 May-Jun;20(3):176-7; author reply 177-9.
      No abstract available. PMID: 19470307

      Eyassu G. Abegaz *
      Robert G. Bursey
      Ajinomoto Corporate Services LLC, Scientific & Regulatory
      Affairs, 1120 Connecticut Ave., N.W., Suite 1010,
      Washington, DC 20036
      * Corresponding author. Tel.: +1 202 457 0284;
      fax: +1 202 457 0107.
      abegazee@... (E.G. Abegaz),
      burseyb@... (R.G. Bursey)

      "For example, fruit juices, coffee, and alcoholic beverages
      produce significantly greater quantities of formaldehyde than
      aspartame-containing products. [6]"

      "[6] Magnuson BA, Burdock GA, Doull J, et al. Aspartame:
      a safety evaluation based on current use levels, regulations,
      and toxicological and epidemiological studies.
      Crit Rev Toxicol 2007;37:629-727"

      [ two detailed critiques of industry affiliations and biased
      science in 99 page review with 415 references by BA
      Magnuson, GA Burdock and 8 more, Critical Reviews in
      Toxicology, 2007 Sept.: Mark D Gold 13 page:
      also Rich Murray 2007.09.15: 2008.03.24
      Monday, March 24, 2008

      "Nearly every section of the Magnuson (2007) review has
      research that is misrepresented
      and/or crucial pieces of information are left out.

      In addition to the misrepresentation of the research,
      readers (including medical professionals) are often not told
      that this review was funded by the aspartame manufacturer,
      Ajinomoto, and the reviewers had enormous conflicts of
      interest." ]


      Dermatitis. 2008; 19(3): E10-E11.
      © 2008 American Contact Dermatitis Society
      Formaldehyde, Aspartame, and Migraines:
      A Possible Connection
      Sharon E. Jacob; Sarah Stechschulte
      Published: 09/17/2008
      [ Extract ]


      Aspartame is a widely used artificial sweetener that has been
      linked to pediatric and adolescent migraines.
      Upon ingestion, aspartame is broken, converted, and oxidized
      into formaldehyde in various tissues.
      We present the first case series of aspartame-associated
      migraines related to clinically relevant positive reactions to
      formaldehyde on patch testing.

      Case Series

      Six patients (ages 16 to 75 years) were referred for evaluation
      of recalcitrant dermatitis. By history, five of the patients were
      noted to have developed migraines following aspartame
      consumption; the sixth reported dermatitis flares associated
      with diet cola consumption of >2 liters/day.

      All six patients had current environmental exposures to
      formaldehyde or formaldehyde-releasing preservatives in
      their personal hygiene products and/or regular consumption
      of "sugar-free food" artificially sweetened with aspartame.

      Based on their histories and clinical presentations, these
      patients were patch-tested with the North American Contact
      Dermatitis Group 65-allergen Standard Screening Series and
      selected chemicals from the University of Miami vehicle,
      fragrance, bakery, and textile trays.

      All six patients had positive reactions to formaldehyde, and
      four had additional positive reactions to
      formaldehyde-releasing preservatives (FRPs).
      Expert counseling on allergen avoidance (including avoidance
      of formaldehyde, FRPs, and aspartame) and alternative
      product recommendations were provided to the patients.

      At their follow-up appointments (between 8 and 12 weeks),
      all the patients showed clearance of their dermatitis. Four
      patients (two inadvertently) resumed their consumption of
      aspartame and subsequently returned for an additional
      follow-up visit. Three of the first five patients had recurrences
      of both their migraines and their dermatitis; the sixth patient
      (who had no migraines) had a positive rechallenge dermatitis.
      These four patients were again counseled on avoidance

      formaldehyde, aspartame, and migraines, the first case series,
      Sharon E Jacob-Soo, Sarah A Stechschulte, UCSD,
      Dermatitis 2008 May: Rich Murray 2008.07.18
      Friday, July 18, 2008

      Skin & Aging Journal
      Skin & Aging - ISSN: 1096-0120 - Volume 13 - Issue 12_2005 -
      December 2005 - Pages: 22 - 27

      Allergen Focus:
      Focus on T.R.U.E. Test Allergens #21, 13 and 18:
      Formaldehyde and Formaldehyde-Releasing Preservatives
      -- By Sharon E. Jacob, M.D., Tace Steele, B.A., [now MD]
      and Georgette Rodriguez, M.D., M.P.H.

      formaldehyde from many sources, including aspartame, is
      major cause of Allergic Contact Dermatitis, SE Jacob,
      T Steele, G Rodriguez, Skin and Aging 2005 Dec.:
      Murray 2008.03.27
      Thursday, March 27, 2008



      Avoiding formaldehyde allergic reactions in children
      Pediatric Annals. 2007 Jan.; 36(1): 55-6. PMID: 17269284
      Sharon E. Jacob, MD, Director, Contact Dermatitis Clinic,
      Dept. of Dermatology and Cutaneous Surgery, U. of Miami,
      1295 NW 14th St., Miami, FL 33125

      "For example, diet soda and yogurt containing aspartame
      (Nutrasweet), release formaldehyde in their natural biological

      One of aspartame's metabolites, aspartic acid methyl ester, is
      converted to methanol in the body, which is oxidized to
      formaldehyde in all organs, including the liver and eyes. 22

      Patients with a contact dermatitis to formaldehyde have been
      seen to improve once aspartame is avoided. 22

      Notably, the case that Hill and Belsito reported had a 6-month
      history of eyelid dermatitis that subsided after 1 week of
      avoiding diet soda. 22"

      Avoiding formaldehyde allergic reactions in children,
      aspartame, vitamins, shampoo, conditioners, hair gel, baby
      wipes, Sharon E Jacob, MD, Tace Steele, U. Miami,
      Pediatric Annals 2007 Jan.: eyelid contact dermatitis,
      AM Hill, DV Belsito, 2003 Nov.: Murray 2008.03.27
      Thursday, March 27, 2008


      Sharon E. Jacob, MD, Assistant Professor of Medicine
      University of California, San Diego 200 W. Arbor Drive
      #8420, San Diego, CA 92103-8420
      Tel: 858-552-8585 ×3504 Fax: 305-675-8317
      Sarah A. Stechschulte, BA sstechschulte@...

      aspartame in Merck Maxalt-MLT worsens migraine,
      AstraZeneca Zomig, Eli Lilly Zyprexa,
      J&J Merck Pepcid AC (Famotidine 10mg) Chewable Tab,
      Pfizer Cool Mint Listerine Pocketpaks: Murray 2002.07.16

      Migraine MLT-Down: an unusual presentation of migraine
      in patients with aspartame-triggered headaches.
      Newman LC, Lipton RB Headache 2001 Oct; 41(9): 899-901.
      [ Merck 10-mg Maxalt-MLT, for migraine, has 3.75 mg aspartame,
      while 12 oz diet soda has 200 mg. ]
      Headache Institute, St. Lukes-Roosevelt Hospital Center,
      New York, NY
      Department of Neurology newmanache@...
      Albert Einstein College of Medicine, Bronx, NY
      Innovative Medical Research RLipton@...

      Blumenthall & Vance: aspartame chewing gum headaches
      Nov 1997: Murray 2002.07.28

      Harvey J. Blumenthal, MD, Dwight A Vance, RPh
      Chewing Gum Headaches. Headache 1997 Nov; 37(10): 665-6.
      Department of Neurology, University of Oklahoma College of
      Medicine, Tulsa, USA. neurotulsa@...
      Aspartame, a popular dietetic sweetener, may provoke headache in
      some susceptible individuals. Herein, we describe three cases of
      young women with migraine who reported their headaches could be
      provoked by chewing gum sweetened with aspartame.
      [ 6-8 mg aspartame per stick chewing gum ]

      methanol (11% of aspartame), made by body into
      formaldehyde in many vulnerable tissues, causes modern
      diseases of civilization, summary of a century of research,
      Woodrow C Monte PhD, Medical Hypotheses journal:
      Rich Murray 2009.11.15
      Sunday, November 15, 2009

      Woodrow C Monte, PhD, Emiritus Prof. Nutrition gives
      many PDFs of reseach -- methanol (11% of aspartame)
      puts formaldehyde into brain and body -- multiple
      sclerosis, Alzheimer's, cancers, birth defects, headaches:
      Rich Murray 2010.05.13
      Thursday, May 13, 2010

      [ Other formaldehyde sources include alcohol drinks and
      tobacco and wood smoke,
      while adequate folic acid levels protect most people,
      but not for brain and retina harm.

      See also:

      sweeteners (aspartame), methanol (becomes formaldehyde),
      and premature babies in Denmark, TI Halldorsson et al
      2010.06.30 AmJClinNutr: Erik Millstone: Betty Martini:
      Rich Murray 2010.07.08
      Thursday, July 8, 2010
      http://groups.yahoo.com/group/aspartameNM/message/1609 ]


      589 references -- click on each title for free pdf of
      abstracts or full texts of most of the reports.

      Article 2 http://www.thetruthaboutstuff.com/review2.html

      Selection from Article 2, Fitness Life, December 2007.

      Here is his very practical advice for diet:


      Methanol: Where Is It Found? How Can It Be Avoided?

      AVOID the following, ranked in order of greatest danger:

      1. Cigarettes.
      2. Diet foods and drinks with aspartame.
      3. Fruit and vegetable products and their juices in bottles,
      cans, or pouches.
      4. Jellies, jams, and marmalades not made fresh and kept
      5. Black currant and tomato juice products, fresh or
      6. Tomato sauces, unless first simmered at least 3 hours
      with an open lid.
      7. Smoked food of any kind, particularly fish and meat.
      8. Sugar-free chewing gum.
      9. Slivovitz: You can consume one alcoholic drink a day
      on this diet -- no more! [ no fruit brandies ]
      10. Overly ripe or near rotting fruits or vegetables.

      Rich Murray, MA
      Boston University Graduate School 1967 psychology,
      BS MIT 1964, history and physics,
      1943 Otowi Road, Santa Fe, New Mexico 87505
      505-501-2298 rmforall@...


      http://RMForAll.blogspot.com new primary archive

      group with 148 members, 1,613 posts in a public archive

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