formaldehyde from 0.2 mg daily methanol from aspartame in Singulair
(montelukast) chewable asthma medicine causes severe allergic dermatitis in
boy, SE Jacob et al, Pediatric Dermatology 2009 Nov: Rich Murray 2010.09.27
Monday, September 27, 2010
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Pediatr Dermatol. 2009 Nov-Dec;26(6):739-43.
Systematized contact dermatitis and montelukast in an atopic boy.
Mari Paz Castanedo-Tardan
Mercedes E. González
Elizabeth A. Connelly
Sharon E. Jacob
University of Miami, Miller School of Medicine,
Department of Dermatology and Cutaneous Surgery,
Miami, Florida, USA.
Article first published online: 2 APR 2009
© 2009 Wiley Periodicals, Inc.
Upon ingestion, the artificial sweetener, aspartame is metabolized to
formaldehyde in the body and has been reportedly associated with systemic
contact dermatitis in patients exquisitely sensitive to formaldehyde.
We present a case of a 9-year-old Caucasian boy with a history of mild
atopic dermatitis that experienced severe systematized dermatitis after
being started on montelukast chewable tablets containing aspartame.
Patch testing revealed multiple chemical sensitivities which included a
positive reaction to formaldehyde.
Notably, resolution of his systemic dermatitis only occurred with
discontinuation of the montelukast chewables.
We present a case of a 9-year-old Caucasian boy with a history of mild
atopic dermatitis (stable on topical ta-crolimus ointment 0.03%), mild
intermittent asthma and known food and environmental allergies diagnosed by
prick testing (egg, soy, and peanut) at 3 years of age, and wheat ...
Montelukast Chewable Tablets
Generic Name: Montelukast
Brand Name: Singulair
Copyright 1996-2009 Cerner Multum, Inc.
Version: 7.03. Revision date: 06/25/2009.
Phenylketonuric patients should be informed that the 4-mg and 5-mg chewable
tablets contain phenylalanine (a component of aspartame), 0.674 and 0.842 mg
per 4-mg and 5-mg chewable tablet, respectively.
[ Since phenylalanine is 50% by weight of aspartame, the dose of aspartame
is 1.348 mg and 1.684 mg, releasing the very small dose of methanol, 11 %,
of 0.148 mg and 0.185 mg, of which about 30% remains in the body as
cumulative durable toxic reaction products, concentrated where the tissues
have high levels of the ADH enzyme, such as brain, retina, skin, liver,
kidney, GI tract, and muscle -- the ADH enzyme turns methanol into
formaldehyde, part of which becomes another toxin, formic acid. ]
A 12-oz can of diet drink has 200 mg aspartame, releasing 22 mg methanol
into the body, resulting in about 7 mg retained toxic products of
formadehyde and formic acid in concentrated locations. ]
Hypersensitivity to any component of this product.
Who should not take SINGULAIR?
Do not take SINGULAIR if you are allergic to any of its ingredients.
Use of this medication is not recommended in children less than 15 years
What is Singulair?
What is the dose of SINGULAIR?
The dose of SINGULAIR prescribed for your or your child's condition is based
2 to 5 years: one 4-mg chewable tablet
6 to 14 years: one 5-mg chewable tablet.
The mean systemic exposure of the 4-mg chewable tablet in pediatric patients
2 to 5 years of age and the 5-mg chewable tablets in pediatric patients 6 to
14 years of age is similar to the mean systemic exposure of the 10-mg
film-coated tablet in adults.
The 5-mg chewable tablet should be used in pediatric patients 6 to 14 years
and the 4-mg chewable tablet should be used in pediatric patients 2 to 5
years of age.
Montelukast sodium, the active ingredient in SINGULAIR, is a selective and
orally active leukotriene receptor antagonist that inhibits the cysteinyl
leukotriene CysLT1 receptor.
Each 4-mg and 5-mg chewable SINGULAIR tablet contains 4.2 and 5.2 mg
montelukast sodium, respectively, which are equivalent to 4 and 5 mg of
Both chewable tablets contain the following inactive ingredients: mannitol,
microcrystalline cellulose, hydroxypropyl cellulose, red ferric oxide,
croscarmellose sodium, cherry flavor, aspartame, and magnesium stearate.
SINGULAIR is indicated for the prophylaxis and chronic treatment of asthma
in adults and pediatric patients 12 months of age and older.
SINGULAIR is indicated for prevention of exercise-induced
bronchoconstriction (EIB) in patients 15 years of age and older.
SINGULAIR is indicated for the relief of symptoms of seasonal allergic
rhinitis in patients 2 years of age and older and perennial allergic
rhinitis in patients 6 months of age and older.
four Murray AspartameNM reviews in SE Jacob & SA
Stechschulte debate with EG Abegaz & RG Bursey of
Ajinomoto re migraines from formaldehyde from aspartame,
Dermatitis 2009 May: TE Hugli -- folic acid with V-C
protects: Rich Murray 2009.08.12
Wednesday, August 12, 2009
[ extracts ]
Formaldehyde, aspartame, migraines: a possible connection.
Abegaz EG, Bursey RG.
Dermatitis. 2009 May-Jun;20(3):176-7; author reply 177-9.
No abstract available. PMID: 19470307
Eyassu G. Abegaz *
Robert G. Bursey
Ajinomoto Corporate Services LLC, Scientific & Regulatory
Affairs, 1120 Connecticut Ave., N.W., Suite 1010,
Washington, DC 20036
* Corresponding author. Tel.: +1 202 457 0284;
fax: +1 202 457 0107.
"For example, fruit juices, coffee, and alcoholic beverages
produce significantly greater quantities of formaldehyde than
aspartame-containing products. "
" Magnuson BA, Burdock GA, Doull J, et al. Aspartame:
a safety evaluation based on current use levels, regulations,
and toxicological and epidemiological studies.
Crit Rev Toxicol 2007;37:629-727"
[ two detailed critiques of industry affiliations and biased
science in 99 page review with 415 references by BA
Magnuson, GA Burdock and 8 more, Critical Reviews in
Toxicology, 2007 Sept.: Mark D Gold 13 page:
also Rich Murray 2007.09.15: 2008.03.24
Monday, March 24, 2008
"Nearly every section of the Magnuson (2007) review has
research that is misrepresented
and/or crucial pieces of information are left out.
In addition to the misrepresentation of the research,
readers (including medical professionals) are often not told
that this review was funded by the aspartame manufacturer,
Ajinomoto, and the reviewers had enormous conflicts of
Dermatitis. 2008; 19(3): E10-E11.
© 2008 American Contact Dermatitis Society
Formaldehyde, Aspartame, and Migraines:
A Possible Connection
Sharon E. Jacob; Sarah Stechschulte
[ Extract ]
Aspartame is a widely used artificial sweetener that has been
linked to pediatric and adolescent migraines.
Upon ingestion, aspartame is broken, converted, and oxidized
into formaldehyde in various tissues.
We present the first case series of aspartame-associated
migraines related to clinically relevant positive reactions to
formaldehyde on patch testing.
Six patients (ages 16 to 75 years) were referred for evaluation
of recalcitrant dermatitis. By history, five of the patients were
noted to have developed migraines following aspartame
consumption; the sixth reported dermatitis flares associated
with diet cola consumption of >2 liters/day.
All six patients had current environmental exposures to
formaldehyde or formaldehyde-releasing preservatives in
their personal hygiene products and/or regular consumption
of "sugar-free food" artificially sweetened with aspartame.
Based on their histories and clinical presentations, these
patients were patch-tested with the North American Contact
Dermatitis Group 65-allergen Standard Screening Series and
selected chemicals from the University of Miami vehicle,
fragrance, bakery, and textile trays.
All six patients had positive reactions to formaldehyde, and
four had additional positive reactions to
formaldehyde-releasing preservatives (FRPs).
Expert counseling on allergen avoidance (including avoidance
of formaldehyde, FRPs, and aspartame) and alternative
product recommendations were provided to the patients.
At their follow-up appointments (between 8 and 12 weeks),
all the patients showed clearance of their dermatitis. Four
patients (two inadvertently) resumed their consumption of
aspartame and subsequently returned for an additional
follow-up visit. Three of the first five patients had recurrences
of both their migraines and their dermatitis; the sixth patient
(who had no migraines) had a positive rechallenge dermatitis.
These four patients were again counseled on avoidance
formaldehyde, aspartame, and migraines, the first case series,
Sharon E Jacob-Soo, Sarah A Stechschulte, UCSD,
Dermatitis 2008 May: Rich Murray 2008.07.18
Friday, July 18, 2008
Skin & Aging Journal
Skin & Aging - ISSN: 1096-0120 - Volume 13 - Issue 12_2005 -
December 2005 - Pages: 22 - 27
Focus on T.R.U.E. Test Allergens #21, 13 and 18:
Formaldehyde and Formaldehyde-Releasing Preservatives
-- By Sharon E. Jacob, M.D., Tace Steele, B.A., [now MD]
and Georgette Rodriguez, M.D., M.P.H.
formaldehyde from many sources, including aspartame, is
major cause of Allergic Contact Dermatitis, SE Jacob,
T Steele, G Rodriguez, Skin and Aging 2005 Dec.:
Thursday, March 27, 2008
Avoiding formaldehyde allergic reactions in children
Pediatric Annals. 2007 Jan.; 36(1): 55-6. PMID: 17269284
Sharon E. Jacob, MD, Director, Contact Dermatitis Clinic,
Dept. of Dermatology and Cutaneous Surgery, U. of Miami,
1295 NW 14th St., Miami, FL 33125
"For example, diet soda and yogurt containing aspartame
(Nutrasweet), release formaldehyde in their natural biological
One of aspartame's metabolites, aspartic acid methyl ester, is
converted to methanol in the body, which is oxidized to
formaldehyde in all organs, including the liver and eyes. 22
Patients with a contact dermatitis to formaldehyde have been
seen to improve once aspartame is avoided. 22
Notably, the case that Hill and Belsito reported had a 6-month
history of eyelid dermatitis that subsided after 1 week of
avoiding diet soda. 22"
Avoiding formaldehyde allergic reactions in children,
aspartame, vitamins, shampoo, conditioners, hair gel, baby
wipes, Sharon E Jacob, MD, Tace Steele, U. Miami,
Pediatric Annals 2007 Jan.: eyelid contact dermatitis,
AM Hill, DV Belsito, 2003 Nov.: Murray 2008.03.27
Thursday, March 27, 2008
Sharon E. Jacob, MD, Assistant Professor of Medicine
University of California, San Diego 200 W. Arbor Drive
#8420, San Diego, CA 92103-8420
Tel: 858-552-8585 ×3504 Fax: 305-675-8317
Sarah A. Stechschulte, BA sstechschulte@...
aspartame in Merck Maxalt-MLT worsens migraine,
AstraZeneca Zomig, Eli Lilly Zyprexa,
J&J Merck Pepcid AC (Famotidine 10mg) Chewable Tab,
Pfizer Cool Mint Listerine Pocketpaks: Murray 2002.07.16
Migraine MLT-Down: an unusual presentation of migraine
in patients with aspartame-triggered headaches.
Newman LC, Lipton RB Headache 2001 Oct; 41(9): 899-901.
[ Merck 10-mg Maxalt-MLT, for migraine, has 3.75 mg aspartame,
while 12 oz diet soda has 200 mg. ]
Headache Institute, St. Lukes-Roosevelt Hospital Center,
New York, NY
Department of Neurology newmanache@...
Albert Einstein College of Medicine, Bronx, NY
Innovative Medical Research RLipton@...
Blumenthall & Vance: aspartame chewing gum headaches
Nov 1997: Murray 2002.07.28
Harvey J. Blumenthal, MD, Dwight A Vance, RPh
Chewing Gum Headaches. Headache 1997 Nov; 37(10): 665-6.
Department of Neurology, University of Oklahoma College of
Medicine, Tulsa, USA. neurotulsa@...
Aspartame, a popular dietetic sweetener, may provoke headache in
some susceptible individuals. Herein, we describe three cases of
young women with migraine who reported their headaches could be
provoked by chewing gum sweetened with aspartame.
[ 6-8 mg aspartame per stick chewing gum ]
methanol (11% of aspartame), made by body into
formaldehyde in many vulnerable tissues, causes modern
diseases of civilization, summary of a century of research,
Woodrow C Monte PhD, Medical Hypotheses journal:
Rich Murray 2009.11.15
Sunday, November 15, 2009
Woodrow C Monte, PhD, Emiritus Prof. Nutrition gives
many PDFs of reseach -- methanol (11% of aspartame)
puts formaldehyde into brain and body -- multiple
sclerosis, Alzheimer's, cancers, birth defects, headaches:
Rich Murray 2010.05.13
Thursday, May 13, 2010
[ Other formaldehyde sources include alcohol drinks and
tobacco and wood smoke,
while adequate folic acid levels protect most people,
but not for brain and retina harm.
sweeteners (aspartame), methanol (becomes formaldehyde),
and premature babies in Denmark, TI Halldorsson et al
2010.06.30 AmJClinNutr: Erik Millstone: Betty Martini:
Rich Murray 2010.07.08
Thursday, July 8, 2010
589 references -- click on each title for free pdf of
abstracts or full texts of most of the reports.
Article 2 http://www.thetruthaboutstuff.com/review2.html
Selection from Article 2, Fitness Life, December 2007.
Here is his very practical advice for diet:
Methanol: Where Is It Found? How Can It Be Avoided?
AVOID the following, ranked in order of greatest danger:
2. Diet foods and drinks with aspartame.
3. Fruit and vegetable products and their juices in bottles,
cans, or pouches.
4. Jellies, jams, and marmalades not made fresh and kept
5. Black currant and tomato juice products, fresh or
6. Tomato sauces, unless first simmered at least 3 hours
with an open lid.
7. Smoked food of any kind, particularly fish and meat.
8. Sugar-free chewing gum.
9. Slivovitz: You can consume one alcoholic drink a day
on this diet -- no more! [ no fruit brandies ]
10. Overly ripe or near rotting fruits or vegetables.
Rich Murray, MA
Boston University Graduate School 1967 psychology,
BS MIT 1964, history and physics,
1943 Otowi Road, Santa Fe, New Mexico 87505
new primary archive
group with 148 members, 1,613 posts in a public archive
group with 1215 members, 24,105 posts in a public archive
participant, Santa Fe Complex www.sfcomplex.org