formaldehyde from 11% methanol part of aspartame causes severe allergic dermatitis in boy, JE Jacob et al, Pediatric Dermatology 2009 Nov: Rich Murray 2010.03.30
- formaldehyde from 11% methanol part of aspartame causes severe allergic
dermatitis in boy, JE Jacob et al, Pediatric Dermatology 2009 Nov: Rich
Tuesday, March 30, 2010
Pediatric Dermatology. 2009 Nov-Dec;26(6):739-43.
Systematized contact dermatitis and montelukast in an atopic
University of Miami, Miller School of Medicine, Department
of Dermatology and Cutaneous Surgery, Miami, Florida,
Upon ingestion, the artificial sweetener, aspartame is
metabolized to formaldehyde in the body and has been
reportedly associated with systemic contact dermatitis in
patients exquisitely sensitive to formaldehyde.
We present a case of a 9-year-old Caucasian boy with a
history of mild atopic dermatitis that experienced severe
systematized dermatitis after being started on montelukast
chewable tablets containing aspartame.
Patch testing revealed multiple chemical sensitivities which
included a positive reaction to formaldehyde.
Notably, resolution of his systemic dermatitis only occurred
with discontinuation of the montelukast chewables.
four Murray AspartameNM reviews in SE Jacob & SA
Stechschulte debate with EG Abegaz & RG Bursey of
Ajinomoto re migraines from formaldehyde from aspartame,
Dermatitis 2009 May: TE Hugli -- folic acid with V-C
protects: Rich Murray 2009.08.12
Wednesday, August 12, 2009
[ extracts ]
Formaldehyde, aspartame, migraines: a possible connection.
Abegaz EG, Bursey RG.
Dermatitis. 2009 May-Jun;20(3):176-7; author reply 177-9.
No abstract available. PMID: 19470307
Eyassu G. Abegaz *
Robert G. Bursey
Ajinomoto Corporate Services LLC, Scientific & Regulatory
Affairs, 1120 Connecticut Ave., N.W., Suite 1010,
Washington, DC 20036
* Corresponding author. Tel.: +1 202 457 0284;
fax: +1 202 457 0107.
abegazee@... (E.G. Abegaz),
burseyb@... (R.G. Bursey)
"For example, fruit juices, coffee, and alcoholic beverages
produce significantly greater quantities of formaldehyde than
aspartame-containing products. "
" Magnuson BA, Burdock GA, Doull J, et al. Aspartame:
a safety evaluation based on current use levels, regulations,
and toxicological and epidemiological studies.
Crit Rev Toxicol 2007;37:629-727"
[ two detailed critiques of industry affiliations and biased
science in 99 page review with 415 references by BA
Magnuson, GA Burdock and 8 more, Critical Reviews in
Toxicology, 2007 Sept.: Mark D Gold 13 page:
also Rich Murray 2007.09.15: 2008.03.24
Monday, March 24, 2008
"Nearly every section of the Magnuson (2007) review has
research that is misrepresented
and/or crucial pieces of information are left out.
In addition to the misrepresentation of the research,
readers (including medical professionals) are often not told
that this review was funded by the aspartame manufacturer,
Ajinomoto, and the reviewers had enormous conflicts of
Dermatitis. 2008; 19(3): E10-E11.
© 2008 American Contact Dermatitis Society
Formaldehyde, Aspartame, and Migraines:
A Possible Connection
Sharon E. Jacob; Sarah Stechschulte
[ Extract ]
Aspartame is a widely used artificial sweetener that has been
linked to pediatric and adolescent migraines.
Upon ingestion, aspartame is broken, converted, and oxidized
into formaldehyde in various tissues.
We present the first case series of aspartame-associated
migraines related to clinically relevant positive reactions to
formaldehyde on patch testing.
Six patients (ages 16 to 75 years) were referred for evaluation
of recalcitrant dermatitis. By history, five of the patients were
noted to have developed migraines following aspartame
consumption; the sixth reported dermatitis flares associated
with diet cola consumption of >2 liters/day.
All six patients had current environmental exposures to
formaldehyde or formaldehyde-releasing preservatives in
their personal hygiene products and/or regular consumption
of "sugar-free food" artificially sweetened with aspartame.
Based on their histories and clinical presentations, these
patients were patch-tested with the North American Contact
Dermatitis Group 65-allergen Standard Screening Series and
selected chemicals from the University of Miami vehicle,
fragrance, bakery, and textile trays.
All six patients had positive reactions to formaldehyde, and
four had additional positive reactions to
formaldehyde-releasing preservatives (FRPs).
Expert counseling on allergen avoidance (including avoidance
of formaldehyde, FRPs, and aspartame) and alternative
product recommendations were provided to the patients.
At their follow-up appointments (between 8 and 12 weeks),
all the patients showed clearance of their dermatitis. Four
patients (two inadvertently) resumed their consumption of
aspartame and subsequently returned for an additional
follow-up visit. Three of the first five patients had recurrences
of both their migraines and their dermatitis; the sixth patient
(who had no migraines) had a positive rechallenge dermatitis.
These four patients were again counseled on avoidance
formaldehyde, aspartame, and migraines, the first case series,
Sharon E Jacob-Soo, Sarah A Stechschulte, UCSD,
Dermatitis 2008 May: Rich Murray 2008.07.18
Friday, July 18, 2008
formaldehyde from many sources, including aspartame, is
major cause of Allergic Contact Dermatitis, SE Jacob,
T Steele, G Rodriguez, Skin and Aging 2005 Dec.:
Thursday, March 27, 2008
"For example, diet soda and yogurt containing aspartame
(Nutrasweet), release formaldehyde in their natural biological
One of aspartame's metabolites, aspartic acid methyl ester, is
converted to methanol in the body, which is oxidized to
formaldehyde in all organs, including the liver and eyes. 22
Patients with a contact dermatitis to formaldehyde have been
seen to improve once aspartame is avoided. 22
Notably, the case that Hill and Belsito reported had a 6-month
history of eyelid dermatitis that subsided after 1 week of
avoiding diet soda. 22"
Avoiding formaldehyde allergic reactions in children,
aspartame, vitamins, shampoo, conditioners, hair gel, baby
wipes, Sharon E Jacob, MD, Tace Steele, U. Miami,
Pediatric Annals 2007 Jan.: eyelid contact dermatitis,
AM Hill, DV Belsito, 2003 Nov.: Murray 2008.03.27
Thursday, March 27, 2008
Sharon E. Jacob, MD, Assistant Professor of Medicine
University of California, San Diego 200 W. Arbor Drive
#8420, San Diego, CA 92103-8420
Tel: 858-552-8585 ×3504 Fax: 305-675-8317
Sarah A. Stechschulte, BA sstechschulte@...
methanol (11% of aspartame), made by body into
formaldehyde in many vulnerable tissues, causes modern
diseases of civilization, summary of a century of research,
Woodrow C Monte PhD, Medical Hypotheses journal:
Rich Murray 2009.11.15
Sunday, November 15, 2009
Rich Murray, MA
Boston University Graduate School 1967 psychology,
BS MIT 1964, history and physics,
1943 Otowi Road, Santa Fe, New Mexico 87505
http://RMForAll.blogspot.com new primary archive
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