Tony E Hugli PhD, CEO HealthAide, Inc., offers courteous detailed claims for the benefits and safety of aspartame: Rich Murray 2009.08.13
- Tony E Hugli PhD, CEO HealthAide, Inc., offers courteous detailed claims for
the benefits and safety of aspartame: Rich Murray 2009.08.13
Thursday, August 13, 2009
From: Tony Hugli
Sent: Thursday, August 13, 2009 11:50 AM
To: 'Rich Murray'
Subject: RE: four Murray AspartameNM reviews in SE Jacob &
SA Stechschulte debate with EG Abegaz & RG Bursey of
Ajinomoto re migraines from formaldehyde from aspartame,
Dermatitis 2009 May: TE Hugli -- folic acid with V-C protects:
Rich Murray 2009.08.12
Dr. Tony Hugli, CEO, HealthAide, Inc. (858) 455-3892
Some facts that you may not know about Aspartame:
Did you know Aspartame is an analgesic equal in potency to
aspirin, but without the ability to acetylate and thus causes less
tissue injury (i.e. less gastric side effects)?
Thus, Aspartame is safer than Aspirin for reducing stroke and
heart attacks based on its blood thinning properties.
FACT: Aspartame inhibits both COX-1 and COX-2
enzymes making it a NSAID.
It is certainly much safer than acetometaphen, a true liver toxin.
Our assays were done by a third party academic researcher.
Did you know that on long term use (i.e. 6-12 months), at an
appropriate level, Aspartame increases bone density in mice
(FACT) and we have anecdotal evidence in humans?
I have mechanism data to support this claim.
Therefore, Aspartame is a safer treatment for osteoporosis
than the bisphosphates.
Did you know that we are testing Aspartame in our topical
formulation on psoriasis?
If our topical lotion treats either the symptoms or the mechanism
causing psoriasis, it will much safer that the ingestible
immunosuppressive drugs (Reptiva, etc.) being used for this
skin condition (FACT).
These ingested immunosuppressive drugs have killed people due
to infections caused by compromising the immune response
Did you know that when Aspartame is added to whole human
blood it reduced the release of an entire host of inflammatory
cytokines, thus explaining why it has such impressive effects on
inflammatory skin problems? (FACT)
These blood studies were done for us by an independent assay
Did you know that vegetarians who drink wine or liquor ingest
4-5 times more methanol than those drinking 1-2 diet sodas a day?
Are there individuals who are hypersensitive to this compound
or its breakdown products?
Absolutely, and they will have to be warned to avoid it, just like
those sensitive to peanuts, but we know that their number is
very small and the response has never been anaphylactic or life
This compound has been in our food supply for over 25 years and
over 200 million people ingest several hundred mg of Aspartame
every day without a single confirmed or convincing
epidemiological study to show that it causes specific diseases or
syndromes worse than the effects of simple sugar (diabetes) !!
Our company is focused on topical products to avoid doing any
harm to our users.
However, when you consider the cost, efficacy, and safety
benefits of Aspartame as a single multi-functional drug to treat
osteoporosis, reduce strokes and heart attacks, and provide
pain relief in a mature population, then these benefits may
outweigh the questionable risks.
I would always advocate that anyone taking Aspartame as an
ingestible to supplement it with additional reducing agent and
folic acid as a preventative.
What do you think?
T.E. Hugli, PhD
CEO HealthAide, Inc.
San Diego, CA
From: Rich Murray [mailto:rmforall@...]
Sent: Wednesday, August 12, 2009 10:49 PM
To: email@example.com; aspartameNM@yahoogroups.com
Cc: RichMurray.rmforall@...; rmforall@...
Subject: four Murray AspartameNM reviews in SE Jacob & SA Stechschulte
debate with EG Abegaz & RG Bursey of Ajinomoto re migraines from
formaldehyde from aspartame, Dermatitis 2009 May: TE Hugli -- folic acid
with V-C protects: Rich Murray 2009.08.12
four Murray AspartameNM reviews in SE Jacob & SA Stechschulte debate with EG
Abegaz & RG Bursey of Ajinomoto re migraines from formaldehyde from
aspartame, Dermatitis 2009 May: TE Hugli -- folic acid with V-C protects:
Rich Murray 2009.08.12
Wednesday, August 12, 2009
Thanks, Tony, for the honor of a vigorous, challenging response.
You offer dazzlingly positive opportunities.
I welcome being offered a completely new perspective.
I hope it is OK to share it with aspartameNM and my private
mailing list, so that many others with far more training and
experience than me can contribute in the spirit of civil
collaboration, based on public evidence and reason.
I've considered for years the probability that humans have
uniquely evolved to turn methanol into formaldehyde and
formic acid, because of their potency against parasites,
yeasts, fungi, bacteria, and viruses. If this is so, then there
may be natural biological pathways used by the body to
release formaldehyde where and when it is most effective.
This implies some very fruitful lines of research.
Early man imbided ethanol and methanol from fermented fruit,
and had to tolerate the formaldehyde in wood smoke, while living
in close, crowded quarters in caves and huts, especially in cold
climates. Ethanol must have facilitated sociability, relaxation,
fearlessness, play, sex, and creativity. So, it fits that groups
in northern Europe developed cultures that made wines, beers,
and ales, as recounted in ancient Greek, Hebrew, and Nordic
Folic acid, prominent in fruits and vegetables, protects vegans,
from methanol, unless the dose of methanol is too great,
they have mutations that impede folic acid, or take any of
the many drugs that also interfere with folic acid.
The half-life of ethanol is about 20 minutes, while that of
methanol is about two hours. Only after the ethanol is gone
from the blood, can the methanol impurity then be turned into
formaldehyde and then formic acid. After 13 hours after
a liter of wine with 150 mg methanol is ingested, only about
3% remains to become formaldehyde -- a methanol dose of
about 5 mg.
The 66 mg methanol in a typical liter of aspartame beverage
is very quickly released into the blood -- a dose ten-fold
larger, and about 6 times the daily indigenous methanol
production of about 10 mg.
I hope you will consider studying whether folic acid can prevent
hangovers in most people from alcohol beverages -- a finding
with enormous practical benefits.
I also hope you will be be first to use a major database
to study correlations of aspartame use with symptoms:
Nurses Health Study can quickly reveal the extent of aspartame
(methanol, formaldehyde, formic acid) toxicity:
Murray 2004.11.21 rmforall
Yahoo Groups allows you to search my entire archive of 1,583
posts in a few seconds for any word.
I have added a few posts that may contribute to your work on
I will gladly post anything you provide without editing.
I have always hoped to help catalyze a cooperative community
to contribute to a shared public archive for these opportunities --
an evolving, open source, self-organizing, free public scientific
My ambition is to be left far behind by the pack...
In mutual service, Rich
antiseptic? antifungal? antiviral? methanol (formaldehyde, formic
acid) disposition: Bouchard M et al, full plain text, 2001:
substantial sources are degradation of fruit pectins, liquors,
aspartame, smoke: Murray 2005.01.05 rmforall
Since no adequate data has ever been published on the
exact disposition of toxic metabolites in specific tissues in humans
of the 11 % methanol component of aspartame,
the many studies on morning-after hangover from the methanol
impurity in alcohol drinks are the main available resource to date.
highly toxic formaldehyde, the cause of alcohol hangovers, is
made by the body from 100 mg doses of methanol from
dark wines and liquors, dimethyl dicarbonate, and aspartame:
DMDC: Dimethyl dicarbonate 200mg/L in drinks
adds methanol 98 mg/L ( becomes formaldehyde in body ):
EU Scientific Committee on Foods 2001.07.12:
"...DMDC was evaluated by the SCF in 1990
and considered acceptable for
the cold sterilization of soft drinks and fruit juices at levels of
addition up to 250 mg/L (1)
...DMDC decomposes primarily to CO2 and methanol ...
[ Note: Sterilization of bacteria and fungi is a toxic process,
probably due to the inevitable conversion in the body of methanol
into highly toxic formaldehyde and then formic acid. ]
The use of 200 mg DMDC per liter would add 98 mg/L of
methanol to wine which already contains an average of about
40 mg/L from natural sources.
methanol products (formaldehyde and formic acid) are main
cause of alcohol hangover symptoms [same as from similar
amounts of methanol, the 11% part of aspartame]:
YS Woo et al, 2005 Dec: Murray 2006.01.20
Addict Biol. 2005 Dec;10(4): 351-5.
Concentration changes of methanol in blood samples during
an experimentally induced alcohol hangover state.
Woo YS, Yoon SJ, Lee HK, Lee CU, Chae JH, Lee CT,
Chuncheon National Hospital, Department of Psychiatry,
The Catholic University of Korea, Seoul, Korea.
Songsin Campus: 02-740-9714
Songsim Campus: 02-2164-4116
Songeui Campus: 02-2164-4114
http://www.cuk.ac.kr/eng/sub055.htm eight hospitals
[ Han-Kyu Lee ]
A hangover is characterized by the unpleasant physical and
mental symptoms that occur between 8 and 16 hours after
After inducing experimental hangover in normal individuals,
we measured the methanol concentration prior to
and after alcohol consumption
and we assessed the association between the hangover
condition and the blood methanol level.
A total of 18 normal adult males participated in this study.
They did not have any previous histories of psychiatric
or medical disorders.
The blood ethanol concentration prior to the alcohol intake
(2.26+/-2.08) was not significantly different from that
13 hours after the alcohol consumption (3.12+/-2.38).
However, the difference of methanol concentration
between the day of experiment (prior to the alcohol intake)
and the next day (13 hours after the alcohol intake)
was significant (2.62+/-1.33/l vs. 3.88+/-2.10/l, respectively).
A significant positive correlation was observed
between the changes of blood methanol concentration
and hangover subjective scale score increment when covarying
for the changes of blood ethanol level (r=0.498, p<0.05).
This result suggests the possible correlation of methanol
as well as its toxic metabolite to hangover. PMID: 16318957
[ The toxic metabolite of methanol is formaldehyde, which in turn
partially becomes formic acid -- both potent cumulative toxins
that are the actual cause of the toxicity of methanol.]
This study by Jones AW (1987) found next-morning hangover
from red wine with 100 to 150 mg methanol
(9.5 % w/v ethanol, 100 mg/l methanol, 0.01 %).
Fully 11% of aspartame is methanol --
1,120 mg aspartame in 2 L diet soda,
almost six 12-oz cans, gives 123 mg methanol (wood alcohol).
Pharmacol Toxicol. 1987 Mar; 60(3): 217-20.
Elimination half-life of methanol during hangover.
Jones AW. wayne.jones@...;
Department of Forensic Toxicology,
University Hospital, SE-581 85 Linkoping, Sweden.
This paper reports the elimination half-life of methanol in human
Experiments were made during the morning after the subjects had
consumed 1000-1500 ml red wine
(9.5 % w/v ethanol, 100 mg/l methanol)
the previous evening. [ 100 to 150 mg methanol ]
The washout of methanol from the body
coincided with the onset of hangover.
The concentrations of ethanol and methanol in blood were
determined indirectly by analysis of end-expired alveolar air.
In the morning when blood-ethanol dropped
below the Km of liver alcohol dehydrogenase (ADH)
of about 100 mg/l (2.2 mM),
the disappearance half-life of ethanol was 21, 22, 18 and 15 min.
in 4 test subjects respectively.
The corresponding elimination half-lives of methanol
were 213, 110, 133 and 142 min. in these same individuals.
The experimental design outlined in this paper can be used
to obtain useful data on elimination kinetics of methanol
in human volunteers without undue ethical limitations.
Circumstantial evidence is presented to link methanol
or its toxic metabolic products, formaldehyde and formic acid,
with the pathogenesis of hangover. PMID: 3588516
Thrasher (2001): "The major difference is that the Japanese
demonstrated the incorporation of FA and its metabolites
into the placenta and fetus.
The quantity of radioactivity remaining in maternal and fetal tissues
at 48 hours was 26.9 % of the administered dose." [ Ref. 14-16 ]
Arch Environ Health 2001 Jul-Aug; 56(4): 300-11.
Embryo toxicity and teratogenicity of formaldehyde.
Thrasher JD, Kilburn KH. toxicology@...
Sam-1 Trust, Alto, New Mexico, USA.
http://www.drthrasher.org/formaldehyde_1990.html full text
Jack Dwayne Thrasher, Alan Broughton, Roberta Madison.
Immune activation and autoantibodies in humans
with long-term inhalation exposure to formaldehyde.
Archives of Environmental Health. 1990; 45: 217-223.
"Immune activation, autoantibodies, and anti-HCHO-HSA
antibodies are associated with long-term formaldehyde
inhalation." PMID: 2400243
unexamined cofactors re folic acid antagonist research include
methanol (quickly turns into formaldehyde and then formic acid in
humans) from tobacco and wood smoke, alcohol beverages,
aspartame, demethylation of caffeine: Rich Murray 2008.12.01
Monday, December 1, 2008
Public release date: 1-Dec-2008
Contact: Kim Barnhardt kim.barnhardt@...
Canadian Medical Association Journal
Maternal exposure to folic acid antagonists increases risks
Exposure to folic acid antagonists during pregnancy is associated
with a higher risk of placenta-mediated adverse outcomes such as
preeclampsia, placental abruption, fetal growth restriction or fetal
death reports a retrospective cohort study published in CMAJ
Folic acid antagonists include a broad range of drugs used to
treat epilepsy, mood disorders, hypertension and infections.
As approximately 50% of pregnancies in industrialized countries
like Canada are unplanned, there is a risk of unintended exposure
to these medications.
The study, conducted by researchers from Ottawa, Montreal,
Saskatoon and Hunan, China looked at 14,982 women who had
taken folic acid antagonists one year prior to delivery and 59,825
women who did not. Dr. Shi Wu Wen and co- researchers found
that maternal exposure to folic acid antagonists was associated
with a slightly higher risk of adverse pregnancy outcomes. They
suggest re-classifying some folic acid antagonists and recommend
increased folic acid supplements for women requiring folic acid
antagonists during pregnancy.
In a related commentary http://www.cmaj.ca/press/pg1243.pdf ,
Dr. Joel Ray suggests the research study presents some
"thought-provoking findings, but the results may not be ready for
adoption by clinical practitioners or drug policy makers." He cites
some real concerns with the study design and the need for
clinically relevant finding as cautions about translating findings into
free full text
The New England Jouranal of Medicine
Volume 343: 1608-1614 November 30, 2000 Number 22
Folic Acid Antagonists during Pregnancy and the Risk of Birth
Sonia Hernandez-Diaz, M.D., Dr.P.H.,
Martha M. Werler, Sc.D.,
Alexander M. Walker, M.D., Dr.P.H.,
and Allen A. Mitchell, M.D.
Multivitamin supplementation in pregnant women may reduce the
risks of cardiovascular defects, oral clefts, and urinary tract
defects in their infants.
We evaluated whether the folic acid component of multivitamins
is responsible for the reduction in risk by examining the
associations between maternal use of folic acid antagonists and
these congenital malformations.
We assessed exposure to folic acid antagonists that act as
dihydrofolate reductase inhibitors and to certain antiepileptic
drugs in 3870 infants with cardiovascular defects,
1962 infants with oral clefts,
and 1100 infants with urinary tract defects
and also in 8387 control infants with malformations the risk of
which is not reduced after vitamin supplementation.
Mothers were interviewed within six months after delivery
about their medication use during pregnancy.
The relative risks of cardiovascular defects and oral clefts
in infants whose mothers were exposed to dihydrofolate
reductase inhibitors during the second or third month after the
last menstrual period, as compared with infants whose mothers
had no such exposure, were
3.4 (95 percent confidence interval, 1.8 to 6.4)
and 2.6 (95 percent confidence interval, 1.1 to 6.1), respectively.
The relative risks of cardiovascular defects, oral clefts,
and urinary tract defects
after maternal exposure to antiepileptic drugs were
2.2 (95 percent confidence interval, 1.4 to 3.5),
2.5 (95 percent confidence interval, 1.5 to 4.2),
and 2.5 (95 percent confidence interval, 1.2 to 5.0), respectively.
Use of multivitamin supplements containing folic acid diminished
the adverse effects of dihydrofolate reductase inhibitors, but not
that of antiepileptic drugs.
Folic acid antagonists, which include such common drugs as
trimethoprim, triamterene, carbamazepine, phenytoin,
phenobarbital, and primidone, may increase the risk not only of
neural-tube defects, but also of cardiovascular defects, oral clefts,
and urinary tract defects.
The folic acid component of multivitamins may reduce the risks
of these defects.
From the Slone Epidemiology Unit,
Boston University School of Public Health,
Brookline, Mass. (S.H.-D., M.M.W., A.A.M.);
and the Department of Epidemiology,
Harvard School of Public Health, Boston (S.H.-D., A.M.W.).
Address reprint requests to Dr. Hernandez-Diaz
at the Slone Epidemiology Unit,
Boston University School of Public Health, 1371 Beacon St.,
Brookline, MA 02446, or at shernan@... .
methanol impurity in alcohol drinks [ and aspartame ] is turned into
neurotoxic formic acid, prevented by folic acid, re Fetal Alcohol
Syndrome, BM Kapur, DC Lehotay, PL Carlen at U. Toronto,
Alc Clin Exp Res 2007 Dec. plain text: detailed biochemistry,
CL Nie et al. 2007.07.18: Murray 2008.02.24
Sunday, February 24, 2008
Alcoholism: Clinical and Experimental Research
Volume 31 Issue 12 Page 2114-2120, December 2007
Bhushan M. Kapur, b.kapur@...;
Arthur C. Vandenbroucke, PhD, FCACB
Denis C. Lehotay, dlehotay@...;
Peter L. Carlen carlen@...;
(2007) Formic Acid, a Novel Metabolite of Chronic Ethanol
Abuse, Causes Neurotoxicity, Which Is Prevented by Folic Acid
Alcoholism: Clinical and Experimental Research
31 (12), 2114-2120.
Methanol is endogenously formed in the brain and is present as
a congener in most alcoholic beverages.
Because ethanol is preferentially metabolized over methanol
(MeOH) by alcohol dehydrogenase, it is not surprising that
MeOH accumulates in the alcohol-abusing population.
This suggests that the alcohol-drinking population will have
higher levels of MeOH's neurotoxic metabolite,
formic acid (FA).
FA elimination is mediated by folic acid.
Neurotoxicity is a common result of chronic alcoholism.
This study shows for the first time that FA, found in chronic
alcoholics, is neurotoxic and this toxicity can be mitigated by
folic acid administration.
To determine if FA levels are higher in the alcohol-drinking
population and to assess its neurotoxicity in organotypic
hippocampal rat brain slice cultures.
Serum and CSF FA was measured in samples from both ethanol
abusing and control patients, who presented to a hospital
emergency department. [ CSF = Cerebral Spinal Fluid ]
FA's neurotoxicity and its reversibility by folic acid were
assessed using organotypic rat brain hippocampal slice cultures
using clinically relevant concentrations.
Serum FA levels in the alcoholics
(mean Â± SE: 0.416 +- 0.093 mmol/l, n = 23)
were significantly higher than in controls
(mean Â± SE: 0.154 +- 0.009 mmol/l, n = 82) (p < 0.0002).
FA was not detected in the controls' CSF (n = 20),
whereas it was >0.15 mmol/l in CSF of 3 of the 4 alcoholic cases.
Low doses of FA from 1 to 5 mmol/l
added for 24, 48 or 72 hours to the rat brain slice cultures
caused neuronal death as measured by propidium iodide
When folic acid (1 umol/l) was added with the FA,
neuronal death was prevented. [ umol = micromole ]
Formic acid may be a significant factor in the neurotoxicity
of ethanol abuse.
This neurotoxicity can be mitigated by folic acid administration
at a clinically relevant dose.
Formic Acid, Folic Acid, Methanol, Neurotoxicity, Alcoholism.
From the Department of Clinical Pathology (BMK),
Sunnybrook Health Science
Centre, Division of Clinical Pharmacology and Toxicology,
The Hospital for Sick Children, Toronto, Ontario, Canada;
St. Michael's Hospital (ACV), Toronto, Canada;
Department of Laboratory Medicine and Pathobiology,
(BMK, ACV), Faculty of Medicine, University of Toronto,
Toronto, Ontario, Canada;
Departments of Medicine (Neurology) and Physiology
(YA, PLC), Toronto Western Research Institute,
University of Toronto, Toronto, Ontario, Canada;
and University of Saskatchewan (DLC),
Received for publication May 1, 2007;
accepted September 24, 2007.
Reprint requests: Dr. Bhushan M. Kapur,
Department of Clinical Pathology,
Sunnybrook Health Science Centre, 2075 Bayview Ave,
Toronto, Ontario, M4N 3M5, Canada;
Fax: 416-813-7562; E-mail: b.kapur@...;
Copyright 2007 by the Research Society on Alcoholism. DOI:
Alcoholism: Clinical and Experimental Research 2007 Dec.
Alcohol Clin Exp Res, Vol. 31, No 12, 2007: pp 2114-2120
NEUROTOXICITY AND BRAIN damage are common
concomitants findings of chronic alcoholism
(Carlen and Wilkinson, 1987; Carlen et al., 1981; Harper, 2007).
The cause of ethanol-induced neurotoxicity is still unclear.
We present here a novel hypothesis for neurotoxicity: increased
formic acid (FA) levels produced from methanol (MeOH),
whose catabolism is blocked by ethanol.
Axelrod and Daly (1965) demonstrated the endogenous
formation of MeOH from S-adenosylmethionine (SAM)
in the pituitary glands of humans and various other
Presence of MeOH in the breath of human subjects was
reported by Ericksen and Kulkarni (1963).
Most alcoholic beverages also have a small amount of MeOH
as a congener (Sprung et al., 1988).
As ethanol (EtOH) has a higher affinity for alcohol dehydrogenase
(ADH) than MeOH, EtOH is preferentially metabolized
(Mani et al., 1970).
As a result, MeOH accumulation from endogenously produced
MeOH, and/or, that consumed as part of an alcoholic beverage,
has been reported in concentrations up to 2 mmol/l in heavy
drinkers (Majchrowicz and Mendelson, 1971).
Toxicity resulting from MeOH consumption is extensively
documented in both humans and animals and has been attributed
to its metabolite, FA (Benton and Calhoun, 1952;
Roe, 1946, 1955; Wood, 1912; Wood and Buller, 1904).
The rate of formate oxidation and elimination is dependent on
adequate levels of hepatic folic acid,
particularly hepatic tetrahydrofolate (THF)
(Johlin et al., 1987; Tephly and McMartin, 1974).
Significantly higher formate levels were obtained when
folate-deficient animals were exposed to MeOH as compared
with folate-sufficient animals
(Lee et al., 1994; McMartin et al., 1975; Noker et al., 1980).
To understand ethanol's toxicity, one must consider FA
produced from MeOH,
and its elimination mediated by folic acid.
We postulate that in the chronically drinking patient, we will
find higher levels of FA than in the nondrinking population,
and that formate is neurotoxic.
We also hypothesize that treatment with folic acid,
which is a critical factor in the catabolism of FA,
can prevent or diminish FA neurotoxicity.
detailed critiques of JE Garst folic acid proposals by experts
HJ Roberts and M Alemany: Murray 2008.03.20
Thursday, March 20, 2008
RE: 5 mg folic acid helps methanol to not form toxic
formaldehyde and formic acid -- no effect re formaldehyde
from methanol in human breast and arterial epithelial
tissue: Garth: Monte 2008.03.19
Wednesday, March 19, 2008
5 mg folic acid helps methanol to not form toxic formaldehyde
and formic acid, but most research has neglected folic acid
deficiency re cancer, birth defects, and neurotoxicity -- flaws
in many studies on aspartame -- breakthrough insights by
John E Garst, PhD toxicologist: Murray 2008.03.19
Wednesday, March 19, 2008
details on 6 epidemiological studies since 2004 on diet soda
(mainly aspartame) correlations, as well as 14 other mainstream
studies on aspartame toxicity since summer 2005:
Wednesday, November 14, 2007
old tiger roars -- Woodrow C Monte, PhD -- aspartame causes
many breast cancers, as ADH enzyme in breasts makes methanol
from diet soda into carcinogenic formaldehyde -- same in dark
wines and liquors, Fitness Life 2008 Jan.: Murray 2008.02.11
Monday, February 11, 2008
role of formaldehyde, made by body from methanol from foods
and aspartame, in steep increases in fetal alcohol syndrome,
autism, multiple sclerosis, lupus, teen suicide, breast cancer,
Nutrition Prof. Woodrow C. Monte, retired, Arizona State U.,
two reviews, 190 references supplied, Fitness Life,
New Zealand 2007 Nov, Dec: Murray 2007.12.26
Wednesday, December 26 2007
Monte WC., Is your Diet Sweetener killing you?
Fitness Life. 2007 Nov; 33: 31-33.
Monte WC., A Deadly Experiment.
Fitness Life. 2007 Dec; 34: 38-42.
Monte WC., Bittersweet: Aspartame Breast Cancer Link.
Fitness Life. 2008 Feb; 34: 21-22.
Article 1 http://www.thetruthaboutstuff.com/review1.shtml
Article 2 http://www.thetruthaboutstuff.com/review2.shtml
Article 3 http://www.thetruthaboutstuff.com/review3.shtml
223 references with abstracts or full and partial texts
[ Can anyone find this citation? ]
"Exposure to Formaldehyde From Methanol in Aspartame
As is described later, methanol is metabolized to formaldehyde,
which is rapidly further metabolized."
"For example, the demethylation of the caffeine found in one cup
of coffee produces 30 mg of formaldehyde (Imbus, 1988)."
ASE 151. Imbus, H. R. (1988) A review of regulatory risk
assessment with formaldehyde as an example.
Regulatory Toxicology and Pharmacology 8 , pp. 356-366.
[ crossref ]
[ http://lib.bioinfo.pl/pmid:3905920 [ not in PubMed ]
J Allergy Clin Immunol. 1985 Dec; 76(6):831-40
Clinical evaluation of patients with complaints related to
H R Imbus
Formaldehyde is a very widely used chemical in our present
society and one with which every physician has had a first-hand
experience in his early days of training in the anatomy laboratory.
The National Institute of Occupational Safety and Health lists 52
occupations that expose people to formaldehyde.
In recent years, however, the increasing use of formaldehyde
resins in the production of building materials such as particleboard
and urea-formaldehyde foam insulation has resulted in exposures
of large numbers of people in nonoccupational settings.
Consumer products such as cosmetics, cigarettes, textiles,
furniture, draperies, and preservatives release formaldehyde.
It is present in the outdoor atmosphere from products of
combustion and automobile exhaust and likewise in the home
from such things as gas cooking.
These more widespread and increased exposures have resulted
in concern regarding potential health effects.
Therefore, it is likely that physicians have or will encounter patients
who wish evaluations of a present or potential health effect from
This article is for the purpose of providing assistance in such
Mesh-terms: Acute Disease; Animals; Asthma :: chemically induced;
Chronic Disease; Dermatitis, Contact :: etiology;
Drug Hypersensitivity :: diagnosis;
Drug Hypersensitivity :: etiology; Environmental Exposure;
Formaldehyde :: toxicity; Human; Mice;
Occupational Diseases :: chemically induced;
Radioimmunoassay; Rats; Respiratory Function Tests;
Respiratory Hypersensitivity :: diagnosis;
Skin Tests; Time Factors;
http://www.nclabor.com/osha/etta/indguide/ig31.pdf 38 page
A Guide to Formaldehyde 1988 July H. R. Imbus
Health & Hygiene, Inc.
420 Gallimore Dairy Road, Greensboro, NC 27409
Impact Health Services, Inc. Merged with Health & Hygiene/ELB
In June, 1998, Impact Health Services, Inc., was merged with
U.S. HealthWorks, parent company of Health & Hygiene/ELB.
Impact Health Services is the largest mobile testing company
providing hearing and respiratory surveillance services
throughout the country.
Founded in 1972, and operating out of Kansas City,
Missouri, Impact has grown to serve over 5,000 client sites
in all the 48 continental United States.
Headquartered in Greensboro, North Carolina,
Health & Hygiene/ELB, which was merged with
U.S. HealthWorks in 1996, is one of the country's
largest safety and health consulting companies
offering consulting, training, products and services
in the areas of industrial hygiene, occupational safety and
ergonomics, training, occupational health, hearing conservation,
respiratory surveillance, and OSHA compliance.
As a result of the recent merger,
Health & Hygiene/ELB and Impact Health Services
have been merged to form
U.S. HealthWorks-Preventive Services Division.
U.S. HealthWorks has appointed Jeffrey C. Morrill,
formerly CEO of Impact, as
President of the new Preventive Services Division,
Susan Megerson, formerly President of Impact,
will be managing on-site testing operations,
and Hank Barnum, formerly
Sr. V.P.-Operations of Health & Hygiene/ELB,
will be managing consulting operations.
U.S. HealthWorks-Preventive Services is the nation's largest
training and consulting firm assisting employers and employer
associations with the safety and health concerns of their
We are now also the nation's largest provider of on-site medical
surveillance and training services.
Our mission is to reduce absenteeism and its inherent costs by
helping to provide a workplace free of injuries and illnesses.
This is accomplished by assisting with regulatory compliance
programs (OSHA, DOT, JCAHO, EPA, etc.) and other
preventative measures such as training, loss control,
and elimination of substance abuse.
Workplace absenteeism due to injuries and illnesses represents
an enormous cost to employers in wages for the absent employee
and replacement employee, medical costs, workers compensation
premiums, regulatory fines, legal expenses, retraining and
U.S. HealthWorks-Preventive Services strives to significantly
reduce these costs by emphasizing preventative services and
* Occupational Medicine
* Ergonomics Consultation
* Industrial Hygiene
* Hearing Conservation
* Respiratory Surveillance
* On-Site Medical Monitoring
-Audiometric Testing - Exclusive TTC -Test, Train Counsel
-Medical Clearance for Respirator Use
-Respirator Fit Testing
* Health Management Software & Equipment
* Safety Services
* TIOSH -- Training Institute for Occupational Safety & Health
* Data Management
* On-Site Employee Training
* Customized Hearing Protection and Communication Devices
* Network of Occupational Health Clinics
420 Gallimore Dairy Road
Greensboro, NC 27409
Revised June 25, 1998 ]
opportunities re BA Magnuson, GA Burdock et al., Aspartame
Safety Evaluation 2007 Sept., Critical Reviews in Toxicology:
Rich Murray 2008.07.11
Friday, July 11, 2008
Bernadene A. Magnuson,
George A. Burdock,
Robert M. Kroes, [deceased]
Gary M. Marsh,
Michael W. Pariza,
Peter S. Spencer,
William J. Waddell,
Gary Murray Williams.
"Aspartame: A Safety Evaluation Based on Current Use Levels,
Regulations, and Toxicological and Epidemiological Studies,"
Critical Reviews in Toxicology,
37(8), 629-727, 2007 Sept [415 references]
Bernadene A. Magnuson, Ph.D.
Adjunct Associate Professor, Department of Nutritional Sciences
Senior Scientific and Regulatory Consultant,
Cantox Health Science International,
2233 Argentia Road, Suite 308, Mississauga, ON L5N 2X7
Tel: (905) 542 2900 Fax: (905) 542 1011
Tony E. Hugli has 226 items in PubMed.
www.dermazaide.com/partnership.htm - [Cached Version]
Last Visited: 7/4/2009
# If you represent a skin care development and marketing company
and would like to learn more about partnership opportunities please
contact: Dr. Tony Hugli, CEO, HealthAide, Inc. (858) 455-3892
# New company explores novel therapeutic uses for... --
[Cached Version] Published on: 8/27/2004 Last Visited: 6/29/2005
According to HealthAide CEO Dr. Tony E. Hugli, the company will
investigate a wide variety of health and medical applications for the
sweetener ."Many of the applications that we have planned are
enhancements of existing brand-name products that are already
generating multi-million dollar annual sales," he said. ...
CEO Hugli expects that this edge will translate into dollars and cents
on the company's bottom line."HealthAide will have very low
overhead and operational expenses, which affords us the opportunity
to become profitable sooner than is normally expected," he said.
HealthAide's management team consists of:
CEO: Dr. Tony E. Hugli,
Scientific Director, California Toxicology Research Institute
# View Online Source
Scientific Advisory Board - Antigen Express - [Cached Version]
Published on: 3/25/2006 Last Visited: 6/25/2009
Tony Hugli, Ph.D. Director,
Department of Immunological Toxicology,
Califormia Toxicology Research Institute
Patent title: Multifunctional and combinational application
aspartame and or futhan
Inventors: Tony E. Hugli, John E. Adams
Agents: Martin G. Ozinga;Phillips Murrah, P.C.
Origin: OKLAHOMA CITY, OK US
IPC8 Class: AA61K3124FI
USPC Class: 514542
The present invention is an application, composition, and method of
using a pharmaceutically effective amount of aspartame or its primary
metabolite aspartyl-phenylalanine in systematic and periodic
application or dose as an aspirin (NSAID) substitute, treatment for
osteoporosis, and or topical treatment for Rosacea.
1. A method for treating rosacea in a patient comprising administering
to a patient suffering from rosacea a pharmaceutically effective amount
2. A method for treating osteoporoses in a patient comprising
administering to a patient suffering from osteoporoses a
pharmaceutically effective amount of aspartame.
3. A method of substituting aspartame for aspirin in a patient
comprising administering to a patient a pharmaceutically effective
amount of aspartame instead of aspirin.
CROSS-REFERENCE TO RELATED APPLICATIONS
 Priority is claimed from provisional patent applications
U.S. Ser. No. 60/964,987, filed on Aug. 16, 2007,
and U.S. Ser. No. 60/962,651, filed on Jul. 31, 2007
and incorporated by reference herein.
BACKGROUND OF THE INVENTION
 1. Field of the Invention
 In general, the present invention is an application,
composition, and method of using the dipeptide ester aspartame.
More in particular, the present invention is a systematic and
periodic application of aspartyl-phenylalanyl methyl ester,
hereinafter referred to generally as aspartame, as a topical
formulation and/or an oral formulation for applications utilizing
aspartame beneficial analgesia, anti-inflammatory, osteoporosis,
anti-platelet blood thinning effects and combinations thereof.
It is understood that the current invention may provide a
pharmaceutically effective amount of aspartame or its primary
metabolite aspartyl-phenylalanine as an aspirin (NSAID)
substitute as well as enhance calcium solubility, bio-availability,
absorption, mineral transfer and bone growth for animals and
humans as will be described in greater detail below.
It is also contemplated a pharmaceutically effective amount of
aspartame may be utilized for a topical application for rosacea
Addressing the Potential Side Effects of Aspartame
 Besides addressing the very real problem of Phenylketouria,
and indicating that Aspartame should not be used by individuals with
this condition, there is a major problem associated with claims of
Aspartame being dangerous. The main danger that is cited is that the
breakdown product methanol can be converted (oxidized) to
formaldehyde and large quantities of formaldehyde can be toxic.
These are not biochemically sound assertions and clinical studies
have widely refuted these claims, however the damage has been
done in terms of the general public's perception of the compound.
 The body has several metabolic pathways to deal with both
methanol and formaldehyde, which is found in many foods and are
essential at normal dietary levels. A major pathway is called the
"single carbon metabolism pathway" and it is an essential pathway
for building both protein (i.e. certain amino acids) and nucleic acids.
In fact, when the single carbon pathway dysfunctions humans become
 The single carbon pathway actually utilizes formaldehyde
that is primarily made in the body.
The process involves a vitamin called Folic Acid.
The folic acid is reduced to Tertrahydrofolic Acid by reducing agents
such as ascorbic acid or Vitamin C. See FIG. 4.
In the tetrahydrofolic acid, this compound chemically reacts with
formaldehyde at two sites, the N5 and N10 positions.
This effectively removes formaldehyde from the body or from
embodiment of the invention and the body uses it either for the
metabolism of other body molecules or it is excreted.
In either case, this is a method to detoxify both methanol and
 It is therefore contemplated the above embodiments may
utilize the addition of ascorbic acid (vitamin C) and folic acid along
It is contemplated this may keep the levels of methanol and
formaldehyde low and avoid any side effects from the normal
breakdown of dipeptide ester.
Since both of these ingredients are inexpensive, it may be a
convenient way to effectively neutralize the urban myths about
aspartame being potentially dangerous......
"Of course, everyone chooses, as a natural priority, to enjoy
peace, joy, and love by helping to find, quickly share, and positively
act upon evidence about healthy and safe food, drink, and
Rich Murray, MA Room For All rmforall@...
505-501-2298 1943 Otowi Road, Santa Fe, New Mexico 87505
http://RMForAll.blogspot.com new primary archive
group with 141 members, 1,583 posts in a public archive
group with 1207 members, 23,863 posts in a public archive