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1597formaldehyde from 11% methanol part of aspartame causes severe allergic dermatitis in boy, JE Jacob et al, Pediatric Dermatology 2009 Nov: Rich Murray 2010.03.30

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  • Rich Murray
    Mar 30, 2010
      formaldehyde from 11% methanol part of aspartame causes severe allergic
      dermatitis in boy, JE Jacob et al, Pediatric Dermatology 2009 Nov: Rich
      Murray 2010.03.30
      Tuesday, March 30, 2010

      Pediatric Dermatology. 2009 Nov-Dec;26(6):739-43.
      Systematized contact dermatitis and montelukast in an atopic
      Castanedo-Tardan MP,
      González ME,
      Connelly EA,
      Giordano K,
      Jacob SE.
      University of Miami, Miller School of Medicine, Department
      of Dermatology and Cutaneous Surgery, Miami, Florida,

      Upon ingestion, the artificial sweetener, aspartame is
      metabolized to formaldehyde in the body and has been
      reportedly associated with systemic contact dermatitis in
      patients exquisitely sensitive to formaldehyde.

      We present a case of a 9-year-old Caucasian boy with a
      history of mild atopic dermatitis that experienced severe
      systematized dermatitis after being started on montelukast
      chewable tablets containing aspartame.

      Patch testing revealed multiple chemical sensitivities which
      included a positive reaction to formaldehyde.

      Notably, resolution of his systemic dermatitis only occurred
      with discontinuation of the montelukast chewables.
      PMID: 20199453

      four Murray AspartameNM reviews in SE Jacob & SA
      Stechschulte debate with EG Abegaz & RG Bursey of
      Ajinomoto re migraines from formaldehyde from aspartame,
      Dermatitis 2009 May: TE Hugli -- folic acid with V-C
      protects: Rich Murray 2009.08.12
      Wednesday, August 12, 2009
      [ extracts ]

      Formaldehyde, aspartame, migraines: a possible connection.
      Abegaz EG, Bursey RG.
      Dermatitis. 2009 May-Jun;20(3):176-7; author reply 177-9.
      No abstract available. PMID: 19470307

      Eyassu G. Abegaz *
      Robert G. Bursey
      Ajinomoto Corporate Services LLC, Scientific & Regulatory
      Affairs, 1120 Connecticut Ave., N.W., Suite 1010,
      Washington, DC 20036
      * Corresponding author. Tel.: +1 202 457 0284;
      fax: +1 202 457 0107.
      abegazee@... (E.G. Abegaz),
      burseyb@... (R.G. Bursey)

      "For example, fruit juices, coffee, and alcoholic beverages
      produce significantly greater quantities of formaldehyde than
      aspartame-containing products. [6]"

      "[6] Magnuson BA, Burdock GA, Doull J, et al. Aspartame:
      a safety evaluation based on current use levels, regulations,
      and toxicological and epidemiological studies.
      Crit Rev Toxicol 2007;37:629-727"

      [ two detailed critiques of industry affiliations and biased
      science in 99 page review with 415 references by BA
      Magnuson, GA Burdock and 8 more, Critical Reviews in
      Toxicology, 2007 Sept.: Mark D Gold 13 page:
      also Rich Murray 2007.09.15: 2008.03.24
      Monday, March 24, 2008

      "Nearly every section of the Magnuson (2007) review has
      research that is misrepresented
      and/or crucial pieces of information are left out.

      In addition to the misrepresentation of the research,
      readers (including medical professionals) are often not told
      that this review was funded by the aspartame manufacturer,
      Ajinomoto, and the reviewers had enormous conflicts of
      interest." ]


      Dermatitis. 2008; 19(3): E10-E11.
      © 2008 American Contact Dermatitis Society
      Formaldehyde, Aspartame, and Migraines:
      A Possible Connection
      Sharon E. Jacob; Sarah Stechschulte
      Published: 09/17/2008
      [ Extract ]


      Aspartame is a widely used artificial sweetener that has been
      linked to pediatric and adolescent migraines.
      Upon ingestion, aspartame is broken, converted, and oxidized
      into formaldehyde in various tissues.
      We present the first case series of aspartame-associated
      migraines related to clinically relevant positive reactions to
      formaldehyde on patch testing.

      Case Series

      Six patients (ages 16 to 75 years) were referred for evaluation
      of recalcitrant dermatitis. By history, five of the patients were
      noted to have developed migraines following aspartame
      consumption; the sixth reported dermatitis flares associated
      with diet cola consumption of >2 liters/day.

      All six patients had current environmental exposures to
      formaldehyde or formaldehyde-releasing preservatives in
      their personal hygiene products and/or regular consumption
      of "sugar-free food" artificially sweetened with aspartame.

      Based on their histories and clinical presentations, these
      patients were patch-tested with the North American Contact
      Dermatitis Group 65-allergen Standard Screening Series and
      selected chemicals from the University of Miami vehicle,
      fragrance, bakery, and textile trays.

      All six patients had positive reactions to formaldehyde, and
      four had additional positive reactions to
      formaldehyde-releasing preservatives (FRPs).
      Expert counseling on allergen avoidance (including avoidance
      of formaldehyde, FRPs, and aspartame) and alternative
      product recommendations were provided to the patients.

      At their follow-up appointments (between 8 and 12 weeks),
      all the patients showed clearance of their dermatitis. Four
      patients (two inadvertently) resumed their consumption of
      aspartame and subsequently returned for an additional
      follow-up visit. Three of the first five patients had recurrences
      of both their migraines and their dermatitis; the sixth patient
      (who had no migraines) had a positive rechallenge dermatitis.
      These four patients were again counseled on avoidance

      formaldehyde, aspartame, and migraines, the first case series,
      Sharon E Jacob-Soo, Sarah A Stechschulte, UCSD,
      Dermatitis 2008 May: Rich Murray 2008.07.18
      Friday, July 18, 2008

      formaldehyde from many sources, including aspartame, is
      major cause of Allergic Contact Dermatitis, SE Jacob,
      T Steele, G Rodriguez, Skin and Aging 2005 Dec.:
      Murray 2008.03.27
      Thursday, March 27, 2008

      "For example, diet soda and yogurt containing aspartame
      (Nutrasweet), release formaldehyde in their natural biological

      One of aspartame's metabolites, aspartic acid methyl ester, is
      converted to methanol in the body, which is oxidized to
      formaldehyde in all organs, including the liver and eyes. 22

      Patients with a contact dermatitis to formaldehyde have been
      seen to improve once aspartame is avoided. 22

      Notably, the case that Hill and Belsito reported had a 6-month
      history of eyelid dermatitis that subsided after 1 week of
      avoiding diet soda. 22"

      Avoiding formaldehyde allergic reactions in children,
      aspartame, vitamins, shampoo, conditioners, hair gel, baby
      wipes, Sharon E Jacob, MD, Tace Steele, U. Miami,
      Pediatric Annals 2007 Jan.: eyelid contact dermatitis,
      AM Hill, DV Belsito, 2003 Nov.: Murray 2008.03.27
      Thursday, March 27, 2008

      Sharon E. Jacob, MD, Assistant Professor of Medicine
      University of California, San Diego 200 W. Arbor Drive
      #8420, San Diego, CA 92103-8420
      Tel: 858-552-8585 ×3504 Fax: 305-675-8317
      Sarah A. Stechschulte, BA sstechschulte@...

      methanol (11% of aspartame), made by body into
      formaldehyde in many vulnerable tissues, causes modern
      diseases of civilization, summary of a century of research,
      Woodrow C Monte PhD, Medical Hypotheses journal:
      Rich Murray 2009.11.15
      Sunday, November 15, 2009

      Rich Murray, MA
      Boston University Graduate School 1967 psychology,
      BS MIT 1964, history and physics,
      1943 Otowi Road, Santa Fe, New Mexico 87505
      505-501-2298 rmforall@...


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