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Journal article: Pregnancy outcomes, infant mortality, & As in drinking water, W Bengal India

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  • Suiling Wang
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    Message 1 of 1 , Mar 8, 2006
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      Pregnancy Outcomes, Infant Mortality, and Arsenic in Drinking Water
      in West Bengal, India. OS von Ehrenstein, DNGuha Mazumder, M Hira-
      Smith, N Ghosh, Y Yuan, G Windham, A Ghosh, R Haque, S Lahiri, D
      Kalman, S Das, and AH Smith, American Journal of Epidemiology
      Advance Access published online on March 8, 2006

      [Abstract]Between 2001 and 2003, the authors studied pregnancy outcomes and
      infant mortality among 202 married women in West Bengal, India. Reproductive
      histories were ascertained using structured interviews. Arsenic exposure during
      each pregnancy, including all water sources used, was assessed; this involved
      measurements from 409 wells. Odds ratios for spontaneous abortion, stillbirth,
      neonatal mortality, and infant mortality were estimated with logistic
      regression based on the method of generalized estimating equations. Exposure to
      high concentrations of arsenic (200 µg/liter) during pregnancy was associated
      with a sixfold increased risk of stillbirth after adjustment for potential
      confounders (odds ratio (OR) = 6.07, 95% confidence interval (CI): 1.54, 24.0;
      p = 0.01). Arsenic-related skin lesions were found in 12 women who had a
      substantially increased risk of stillbirth (OR = 13.1, 95% CI: 3.17, 54.0; p =
      0.002). The odds ratio for neonatal death was 2.81 (95% CI: 0.73, 10.8). No
      association was found between arsenic exposure and spontaneous abortion (OR =
      1.01, 95% CI: 0.38, 2.70) or overall infant mortality (OR = 1.33, 95% CI: 0.43,
      4.04). This study adds to the limited evidence that exposure to high
      concentrations of arsenic during pregnancy increases the risk of stillbirth.
      However, there was no indication of the increased rates of spontaneous abortion
      and overall infant mortality that have been reported in some studies.
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