* * * 'Un-Growth Hormone' Increases Longevity
- Ellis: Here is another anti-growth hormone study. It is interesting, and
a bit unsettling to read studies against the use of growth hormone, but
it is going to take more than this to make me stop using HGH. I am not
sure what else MZ-5-156 did...
Maybe it also lowered the mice's blood glucose and this is the reason
why the mice lived longer... I don't know...
I would like to see the OPPOSITE study: growth hormone given to
mice... would THAT decrease their health and increase tumors and
shorten their life span?
I really should enter the Methusalem Mouse contest. I don't know where
to get the mice. Perhaps I could get the mice in England and pay somebody
to administer what I tell them to, and feed them what I tell them to, and
check their blood glucose like I tell them to. - Ellis
'Un-Growth Hormone' Increases Longevity, Researchers Find
ScienceDaily (Dec. 23, 2010)
A compound which acts in the opposite way as growth hormone can reverse
some of the signs of aging, a research team that includes a Saint Louis
University physician has shown.
The finding may be counter-intuitive to some older adults who takegrowth
hormone, thinking it will help revitalize them.
Ellis: We THINK it will revitalize us?
Their research was published in the Dec. 6 online edition of the Proceedings
of the National Academy of Sciences.
The findings are significant, says John E. Morley, M.D., study co-investigator
and director of the divisions of geriatric medicine and endocrinology at
Saint Louis University School of Medicine, because people sometimes take
growth hormone, believing it will be the fountain of youth.
"Many older people have been taking growth hormone to rejuvenate themselves,"
Morley said. "These results strongly suggest that growth hormone, when given to
middle aged and older people, may be hazardous."
The scientists studied the compound MZ-5-156, a "growth hormone-releasing
hormone (GHRH) antagonist." They conducted their research in the SAMP8 mouse
model, a strain engineered for studies of the aging process.
Overall, the researchers found that MZ-5-156 had positive effects on oxidative
stress in the brain, improving cognition, telomerase activity (the actions of an
enzyme which protects DNA material) and life span, while decreasing tumor
MZ-5-156, like many GHRH antagonists, inhibited several human cancers, including
prostate, breast, brain and lung cancers. It also had positive effects on learning, and
is linked to improvements in short-term memory. The antioxidant actions led to
less oxidative stress, reversing cognitive impairment in the aging mouse.
William A. Banks, M.D., lead study author and professor of internal medicine and
geriatrics at the University of Washington School of Medicine in Seattle, said the
results lead the team "to determine that antagonists of growth hormone-releasing
hormone have beneficial effects on aging."
The study team included as its corresponding author Andrew V. Schally, M.D., Ph.D.,
a professor in the department of pathology and division of hematology/oncology
at the University of Miami Miller School of Medicine.
The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Saint Louis University, via EurekAlert!, a service of AAAS.
1.W. A. Banks, J. E. Morley, S. A. Farr, T. O. Price, N. Ercal, I. Vidaurre, A. V. Schally. Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice. Proceedings of the National Academy of Sciences, 2010; 107 (51): 22272 DOI: 10.1073/pnas.1016369107