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572Potential new drug target for cystic fibrosis + Vacancies

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  • pharmacistscoffee
    Sep 21, 2013

       





      Pharmacists_coffee magazine
      Edition No. 524, year 7

      September 20, 2013
      Today’s edition sent to:
      31,571 Arabian Pharmacists


       

       

       








       

       

       



        Find Valuable attachment
        “10 Challenges for Change”
        may find attachment at the end of e-mail

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      Medicine of the week


      Propranolol

       

      Propranolol is a sympatholytic non-selective beta blocker. Sympatholytics are used to treat hypertension, anxiety and panic. It was the first successful beta blocker developed. Propranolol is available in generic form as Propranolol Hydrochloride; marketed in India under brand names like Ciplar and Ciplar LA by Cipla, also other brands from AstraZeneca and Wyeth under brand names Inderal, Inderal LA, Avlocardyl, Deralin, Dociton, Inderalici, InnoPran XL, Sumial, Anaprilinum, Bedranol SR (Sandoz).

      Propranolol is a non-selective beta blocker, that is, it blocks the action of epinephrine and norepinephrine on both β1- and β2-adrenergic receptors. It has little intrinsic sympathomimetic activity (ISA) but has strong membrane stabilizing activity (only at high blood concentrations, e.g. overdosage). Research has also shown that propranolol has inhibitory effects on the norepinephrine transporter and/or stimulates norepinephrine release (present experiments have shown that the concentration of norepinephrine is increased in the synapse but do not have the ability to discern which effect is taking place). Since propranolol blocks β-adrenoceptors, the increase in synaptic norepinephrine only results in α-adrenergic activation, with the α1-adrenoceptor being particularly important for effects observed in animal models. Therefore, some have suggested that it be looked upon as an indirect α1 agonist as well as a β antagonist. Probably owing to the effect at the α1-adrenoceptor, the racemic and the individual enantiomers of propranolol have been shown to substitute for cocaine in rats, with the most potent enantiomer being S-(-)-propranolol. In addition, some evidence suggests that propranolol may function as a partial agonist at one or more serotonin receptors (possibly 5-HT1B).
      Both enantiomers of the drug have a local anesthetic (topical) effect, which is normally mediated by blockade of voltage-gated sodium channels. Few studies have demonstrated propranolol's ability to block cardiac, neuronal, and skeletal voltage-gated sodium channels, accounting for its known "membrane stabilizing effect" and anti-arrhythmic and other central nervous system effects.

       



       


       

       

       

       

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      KSA to KSA
      Add avacancy



      Medical-Rep urgently required.

      Urgently required for a well established medical company in KSA:

      Medical representatives.

      The candidate should be:

      - Presentable, Enthusiastic.

      - Self Motivated, Team worker.

      - High Communication & Presentation Skills.

      - Computer Skills.

      To who would like to join kindly send your C.V. to:

      E-mail: Mbakr@...

       

       

      Pharmacy in Gazan

      Needs pharmacist with transferable iqama

      Salary: 4000 SAR + 500 SAR allowance + 1% from sales

      For more info please call

      Tel: 0500291075

      Or send your CV to:

      arabian_talents@...

       

       

      Medical Rep.

      A medico-cosmetics company is in need for a medical representative to work in Riyadh-KSA.

      Applicants should be:

      1- Pharmacist or Vet.  or any related specialty.

      2- Good experience in the same field is preferred.

      3- Good experience in Riyadh city

      4- Have transferable Iqama

      Excellent salaries and incentives will be applied.

      Please send your C.V to :

      derm.babe@...

       

       

      Nature Care Roxcell INC.

      We are a fast growing international pharmaceutical organization with attractive opportunities for career development.

      Due to our continuous Expansion, Nature Care is proudly announcing the need to recruit highly qualified candidates that are able to execute an effective promotional sales plan, build and develop business relationships in the following positions:

      *National Sales Manager “ Ref. SM” . .

      *Field Force Supervisor “ Ref. FS” All Kingdom . .

      *Medical Representatives “ Ref. MR” All Kingdom . .

      * Institution Specialist “ Ref. IS” All Kingdom . .

      Applicant should have the following criteria:

      1-Transferable Iqama.

      2-Medical background: Pharmacist , Physicians , Vet or Science.

      3- At least 2 years experience in the same position.

      4-Skills: Interpersonal skill , Communication skills , Presentation skills and negotiation skills.

      5-Qualifications: Excellent command of English , excellent computer user.

      6- proven record of achievement.

      We offer an Attractive Packages including (competitive salaries , Health insurance, car policy  & valuable incentive scheme), Positive Career Path, Plus A Winning Culture That Rewards High Performance.

      If you interested, send your C.V. with recent photo on the following Email:

      jobs@...

       

       

      Pharmacy in Saudi Arabia

      Needs pharmacists with transferable iqama

      Benefits:

      1-    Very attractive salary

      2-    Monthly incentive

      3-    Annual salary increase

      4-    Monthly transportation allowance

      5-    Continuous monthly training

      6-    Family insurance (wife + 3 kids)

      7-    Family flight tickets

      8-    Other more benefits

      Tel: 0543397007

      toppharmacy2013@...

       

       

      Job Vacancy in Jeddah

      we are medical company

      We need Science or Pharmacy graduates (Male or Female) for working in Western region :

      1- Bachelor degree in Pharmacy or Science.

      2- Fresh graduates or with experience.

      3- Self-motivated, Ambitious, Honest and Enthusiastic.

      4- Fluent in English.

      5- Computer literate.

      6- Has the ability to learn

      If you have the above mentioned criteria, you are kindly requested to send your CV within 2 weeks to:

      m_sigvaris@...

      or by FAX :00966126828159

       

       

      MEDICAL REPRESENTATIVE VACANCY IN SAUDI ARABIA

      A fast growing national company based in riyadh needs to hire good candidates as a Med Rep ( males and females )  in all regions in KSA ,

      - you must have at least one year experience in sales and promotion preferably in a multinational company.

      - Transferable iqama.

      - valid driving licence for males.

      - past experience with gynacologists is added value .

      - we offer a very competitive package and training .

      - Kindly send your C.V  to    

      info@...

      or

      ayman00sh@...

       

       

      Pharmacist required during Eid El-Adha in Hael

      Pharmacist with transferable iqama

      Call after 1:00 pm

      Tel: 0541793300

       

       

      Required to work part-time urgent

      Required to work part-time sales representative (female) for beauty salons for the distribution of hair products (American brand) in the eastern region – Saudi Arabia..

      Please send CV to .

      Email: ethmadladhair@...

       

       

      Med.Rep. in KSA

      A leading pharmaceutical company Seeking for recruiting Medical Representatives at Qassem region.

      Requirements:

      • · University degree in Bsc.or vet.
      • · TRANSFERABLE Iqama is amust.
      • · Age not more than 28 years old.
      • · Good command of English language and computer skills
      • · Presentable, Hard worker, ambitious.

      Interested applicants send their C.V with a recent photo to

      activemedrep@...

       

       

      Leading Cosmoceutical Company

      A leading cosmoceutical company working in the field of professional & Rx derma products is hiring the following positions for the

      Central Region

      - Field force supervisor  “Ref:  FFS”

      - Medical representative -Male or female-    “Ref:  MR”

      Requirements:

      - To hold a suitable  Medical degree

      - To be currently resident in Riyadh

      - 2 years previous experience in a similar position preferably in the same field

      - Transferable residency

      Kindly send your CV with a recent photo to

      mg.pharma@...

      Please indicate the job reference in the subject

       

       

      Medical Representative Required

      A well established pharmaceutical co. required

      Male Medical Rep.

      for its new line expansion in Quassim, applicant should be:

      - Resident in KSA with transferable iqama and a valid Saudi driving license is a must.

      -Pharmacist or vet. only, Age not more than 28 ys.

      - At least 1 year experience in Saudi market preferred in Quassim area.

      -Has a proven sales records.

      -Work under stress, ambitious and self motivated.

      We offer a good business environment for our people in addition to a good package and a unique incentive scheme.

      If you are interested please send your C.V within 5 days to:

      aranes03@...

       

       

      Nature Care Roxcell INC.

      We are a fast growing international pharmaceutical organization with attractive opportunities for career development.

      Due to our continuous Expansion, Nature Care is proudly announcing the need to recruit highly qualified candidates that are able to execute an effective promotional sales plan, build and develop business relationships in the following positions:

      *National Sales Manager “ Ref. SM” . .

      *Field Force Supervisor “ Ref. FS” All Kingdom . .

      *Medical Representatives “ Ref. MR” All Kingdom . .

      * Institution Specialist “ Ref. IS” All Kingdom . .

      Applicant should have the following criteria:

      1-Transferable Iqama.

      2-Medical background: Pharmacist , Physicians , Vet or Science.

      3- At least 2 years experience in the same position.

      4-Skills: Interpersonal skill , Communication skills , Presentation skills and negotiation skills.

      5-Qualifications: Excellent command of English , excellent computer user.

      6- proven record of achievement.

      We offer an Attractive Packages including (competitive salaries , Health insurance, car policy  & valuable incentive scheme), Positive Career Path, Plus A Winning Culture That Rewards High Performance.

      If you interested, send your C.V. with recent photo on the following Email:

      jobs@...


      Egypt to Gulf
      Add avacancy

       

       

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