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Chemicals may cause range of health ailments

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  • binstock@peakpeak.com
    Chemicals may cause range of health ailments As Europe launches regulations, global scientists huddle on risks By SUSANNE RUST srust@journalsentinel.com
    Message 1 of 1 , Jun 1, 2007
      Chemicals may cause range of health ailments

      As Europe launches regulations, global scientists huddle on risks

      Posted: May 31, 2007

      Copenhagen, Denmark - Are a group of modern chemicals present in everyday
      household products behind increasing rates of breast and testicular
      cancer, male infertility, diabetes and even obesity?

      As new regulations on the chemicals, known as endocrine disrupters, go
      into effect in the European Union today, select scientists from around the
      globe met to share their research and growing concerns.

      Some of the chemicals - found in plastic containers, dental sealants, soda
      and soup can linings, carpets, paints and pesticides - remain virtually
      unregulated in the United States.

      Europe's new rules require that industries that manufacture or import more
      than about 2,200 pounds per year of any given chemical will have to
      provide a risk assessment of that substance. In 2006, the European Union
      adopted a chemical regulation program called REACH - Registration,
      Evaluation, Authorization and Restriction of Chemicals.

      The program puts the burden of risk management onto industry, and away
      from regulators.

      All chemicals will be registered in a central database, overseen by the
      EU's Chemical Agency. Over a period of 11 years, more than 30,000 chemical
      substances will be registered.

      "I think the program is fundamentally good," said Andreas Kortenkamp, a
      researcher at the School of Pharmacy at the University of London.

      Although the regulatory requirements have been "pretty watered down" since
      they were first proposed, the effect of the registration will be to fill
      in "an enormous data gap," he said.

      Indeed, of the 30,000 chemicals required for registration, more than "90
      percent of them have no data," he said. The chemicals that have been
      investigated, he said, were chosen haphazardly - the results of laboratory

      "Now the door is open to apply this more systematically."
      'Complicated system'

      "We have been and continue to be concerned about the REACH program for a
      number of reasons," said Mike Walls, managing director at the
      Virginia-based American Chemistry Council, the trade association that
      represents the U.S. chemical industry.

      Walls called REACH "a very complex and complicated system," and one that
      is untested. "At a minimum we think it is inappropriate to look to REACH
      as a model when there is no experience under it."

      Walls said the U.S. already has the Toxic Substances Control Act enforced
      by the Environmental Protection Agency, and added, "we think that's
      working very well."

      But Frederick vom Saal, an endocrinologist at the University of Missouri,
      was concerned about the EU program's reliance on corporations and

      "They are holding court on this data. They're the ones who will analyze
      the data and present the data," he said.
      Subject of concern

      In a study published in 2005, vom Saal showed that 100% of studies
      conducted by industry on the safety of bisphenol-A, which is an additive
      in polycarbonate plastics, showed that the chemical was safe.

      Not one independent government or academic study has come to the
      conclusion that the chemical is safe, according to vom Saal.

      "We need independent evaluation," vom Saal said.

      For several years, scientists have been concerned about bisphenol-A.
      Hundreds of papers have shown that it can be toxic in extremely low doses.
      The chemical mimics estrogen and binds to estrogen receptors on cells. In
      more than 100 experiments conducted on lab animals, it has been shown to
      cause genetic changes leading to prostate cancer, as well as decreased
      testosterone, low sperm counts and signs of early female puberty. Work
      also has been done on human tissue, with results showing that exposure can
      cause changes in prostate and breast tissue.

      Traces of bisphenol-A have been found in nearly every American tested for it.

      Industry's response

      Industry groups have claimed that the levels at which humans are exposed
      are too low to cause harm. They have provided about a dozen of their own
      studies to support this contention.

      Walls said the public should have confidence in industry studies because
      they are performed in accordance with good laboratory practices, must
      follow a written protocol and must adhere to procedures for accurate and
      complete data collection.

      This week's workshop in Denmark brought together more than 150 top
      researchers in the field and focused on new research exploring these

      Niels Skakkebaek, a researcher at Rigshospitalet in Copenhagen, started
      these workshops after reporting, in the mid-1990s, a precipitous drop in
      sperm quality and quantity in Danish men. He is concerned that these
      chemicals are involved in many of the ailments affecting not only Danes,
      but people throughout the developed world.

      - - - -

      Comment: Publishers invested in various industries are well served to have
      their reporters tout the shibboleths: There really is no epidemic and, if
      there were, it is indeed a "mystery".

      - - - -

      Mark Johnson of the Journal Sentinel staff contributed to this report.

      From the June 1, 2007 editions of the Milwaukee Journal Sentinel

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