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13958Popular Antacids Could Cause Vitamin Deficiency

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  • Donald Christ
    Dec 11, 2013
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      People taking acid-inhibiting medications, such as Prilosec, Zantac, Pepcid, or Nexium, could be short on Vitamin B12.
      According to a new study in the Journal of the American Medical Association, proton pump inhibitors (PPIs) and histamine 2 receptor antagonists (H2RAs) suppress gastric acid production, which can mean that the Vitamin B12 in food is not properly absorbed into the body. Vitamin B12 deficiency is linked to serious health complications, such as anemia, nerve damage, and dementia.
      “Vitamin B12 deficiency is relatively common, especially among older adults; it has potentially serious medical complications if undiagnosed," the authors wrote.
      Scientists from Kaiser Permanente in Oakland, Calif. examined data from 25,956 patients with a new Vitamin B12 deficiency diagnosis between January 1997 and June 2011, and 184,199 patients without Vitamin B12 deficiency. They compared the two groups based on exposure to acid-inhibiting medications.
      Among those who were newly diagnosed with a Vitamin B12 deficiency, 12 percent had been on PPIs for more than two years and 4.2 percent had been on H2RAs for more than two years; 83.8 percent were not on any of the medications. In the control group, 7.2 percent had been on PPIs for two years or more and 3.2 percent had been on H2RAs for more than two years; 89.6 percent were not taking acid-suppressors.
      The researchers concluded that those on PPIs and H2RAs ran a higher risk of Vitamin B12 deficiency. And the higher the dose, the greater the risk.
      They also discovered that the deficiency was more common in women and younger people. Once people stopped taking the medications, their risk went down.
      “We cannot completely exclude residual confounding [factors besides the drugs] as an explanation for these findings, but, at minimum, the use of these medications identifies a population at higher risk of B12 deficiency, independent of additional risk factors,” the authors wrote.
      more -
      I thought that this article might be interesting to those folks who suffer acid-reflex type HCV gastric issues.
      I get tongue sores, and that tells me to take some Vit-B.
      I think it helps - the sores vanish quickly.
      Stay strong everybody, and be well.
      don in ks